Search Results - "Spencer, Kylee"

Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study by Carlson, Christopher S, Matise, Tara C, North, Kari E, Haiman, Christopher A, Fesinmeyer, Megan D, Buyske, Steven, Schumacher, Fredrick R, Peters, Ulrike, Franceschini, Nora, Ritchie, Marylyn D, Duggan, David J, Spencer, Kylee L, Dumitrescu, Logan, Eaton, Charles B, Thomas, Fridtjof, Young, Alicia, Carty, Cara, Heiss, Gerardo, Le Marchand, Loic, Crawford, Dana C, Hindorff, Lucia A, Kooperberg, Charles L

“…The vast majority of genome-wide association study (GWAS) findings reported to date are from populations with European Ancestry (EA), and it is not yet clear…”
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Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration by Haines, Jonathan L, Hauser, Michael A, Schmidt, Silke, Scott, William K, Olson, Lana M, Gallins, Paul, Spencer, Kylee L, Kwan, Shu Ying, Noureddine, Maher, Gilbert, John R, Schnetz-Boutaud, Nathalie, Agarwal, Anita, Postel, Eric A, Pericak-Vance, Margaret A

“…Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous…”
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Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study by Spencer, Kylee L, Malinowski, Jennifer, Carty, Cara L, Franceschini, Nora, Fernández-Rhodes, Lindsay, Young, Alicia, Cheng, Iona, Ritchie, Marylyn D, Haiman, Christopher A, Wilkens, Lynne, Chunyuanwu, Matise, Tara C, Carlson, Christopher S, Brennan, Kathleen, Park, Amy, Rajkovic, Aleksandar, Hindorff, Lucia A, Buyske, Steven, Crawford, Dana C

“…Age at menarche (AM) and age at natural menopause (ANM) define the boundaries of the reproductive lifespan in women. Their timing is associated with various…”
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Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration by Spencer, Kylee L, Olson, Lana M, Schnetz-Boutaud, Nathalie, Gallins, Paul, Agarwal, Anita, Iannaccone, Alessandro, Kritchevsky, Stephen B, Garcia, Melissa, Nalls, Michael A, Newman, Anne B, Scott, William K, Pericak-Vance, Margaret A, Haines, Jonathan L

“…A major goal of personalized medicine is to pre-symptomatically identify individuals at high risk for disease using knowledge of each individual's particular…”
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Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations by Zhang, Lili, Spencer, Kylee L, Voruganti, V Saroja, Jorgensen, Neal W, nage, Myriam, Best, Lyle G, Brown-Gentry, Kristin D, Cole, Shelley A, Crawford, Dana C, Deelman, Ewa, Franceschini, Nora, Gaffo, Angelo L, Glenn, Kimberly R, Heiss, Gerardo, Jenny, Nancy S, Kottgen, Anna, Li, Qiong, Liu, Kiang, Matise, Tara C, North, Kari E, Umans, Jason G, Kao, W H Linda

“…A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric…”
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Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study by Restrepo, Nicole A, Spencer, Kylee L, Goodloe, Robert, Garrett, Tiana A, Heiss, Gerardo, Bůžková, Petra, Jorgensen, Neal, Jensen, Richard A, Matise, Tara C, Hindorff, Lucia A, Klein, Barbara E K, Klein, Ronald, Wong, Tien Y, Cheng, Ching-Yu, Cornes, Belinda K, Tai, E-Shyong, Ritchie, Marylyn D, Haines, Jonathan L, Crawford, Dana C

“…Substantial progress has been made in identifying susceptibility variants for AMD in European populations; however, few studies have been conducted to…”
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Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations The PAGE Study by LILI ZHANG, SPENCER, Kylee L, FRANCESCHINI, Nora, GAFFO, Angelo L, GLENN, Kimberly R, HEISS, Gerardo, JENNY, Nancy S, KOTTGEN, Anna, QIONG LI, KIANG LIU, MATISE, Tara C, NORTH, Kari E, VORUGANTI, V. Saroja, UMANS, Jason G, LINDA KAO, W. H, JORGENSEN, Neal W, FORNAGE, Myriam, BEST, Lyle G, BROWN-GENTRY, Kristin D, COLE, Shelley A, CRAWFORD, Dana C, DEELMAN, Ewa

“…A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric…”
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Cigarette Smoking Strongly Modifies the Association of LOC387715 and Age-Related Macular Degeneration by Schmidt, Silke, Hauser, Michael A., Scott, William K., Postel, Eric A., Agarwal, Anita, Gallins, Paul, Wong, Frank, Chen, Yu Sarah, Spencer, Kylee, Schnetz-Boutaud, Nathalie, Haines, Jonathan L., Pericak-Vance, Margaret A.

“…We used iterative association mapping to identify a susceptibility gene for age-related macular degeneration (AMD) on chromosome 10q26, which is one of the…”
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Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration by Spencer, Kylee L., Hauser, Michael A., Olson, Lana M., Schmidt, Silke, Scott, William K., Gallins, Paul, Agarwal, Anita, Postel, Eric A., Pericak-Vance, Margaret A., Haines, Jonathan L.

“…Age-related macular degeneration (AMD) is a devastating disorder of the central retina, causing significant visual impairment for 7.5 million elderly…”
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Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration by Spencer, Kylee L., Hauser, Michael A., Olson, Lana M., Schmidt, Silke, Scott, William K., Gallins, Paul, Agarwal, Anita, Postel, Eric A., Pericak-Vance, Margaret A., Haines, Jonathan L.

“…Age-related macular degeneration (AMD) impairs vision for ∼7.5 million Americans. Both susceptibility variants and protective haplotypes in the complement…”
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Localization of Age-Related Macular Degeneration-Associated ARMS2 in Cytosol, Not Mitochondria by Wang, Gaofeng, Spencer, Kylee L, Court, Brenda L, Olson, Lana M, Scott, William K, Haines, Jonathan L, Pericak-Vance, Margaret A

“…To analyze the relationship between ARMS2 and HTRA1 in the association with age-related macular degeneration (AMD) in an independent case-control dataset and…”
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C3 R102G polymorphism increases risk of age-related macular degeneration by Spencer, Kylee L., Olson, Lana M., Anderson, Brent M., Schnetz-Boutaud, Nathalie, Scott, William K., Gallins, Paul, Agarwal, Anita, Postel, Eric A., Pericak-Vance, Margaret A., Haines, Jonathan L.

“…Inflammation has long been suspected to play a role in the pathogenesis of age-related macular degeneration (AMD). Association of variants in the complement…”
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Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration by Canter, Jeffrey A, Olson, Lana M, Spencer, Kylee, Schnetz-Boutaud, Nathalie, Anderson, Brent, Hauser, Michael A, Schmidt, Silke, Postel, Eric A, Agarwal, Anita, Pericak-Vance, Margaret A, Sternberg, Jr, Paul, Haines, Jonathan L

“…The objective of this study was to determine if MTND2*LHON4917G (4917G), a specific non-synonymous polymorphism in the mitochondrial genome previously…”
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Analysis of the indel at the ARMS2 3′UTR in age-related macular degeneration by Wang, Gaofeng, Spencer, Kylee L, Scott, William K, Whitehead, Patrice, Court, Brenda L, Ayala-Haedo, Juan, Mayo, Ping, Schwartz, Stephen G, Kovach, Jaclyn L, Gallins, Paul, Polk, Monica, Agarwal, Anita, Postel, Eric A, Haines, Jonathan L, Pericak-Vance, Margaret A

“…Controversy remains as to which gene at the chromosome 10q26 locus confers risk for age-related macular degeneration (AMD) and statistical genetic analysis is…”
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Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium by HAIMAN, Christopher A, FESINMEYER, Megan D, JACKSON, Rebecca D, FLOREZ, Jose C, KOLONEL, Laurence N, BUYSKE, Steven, GOODLOE, Robert J, SIMIN LIU, MANSON, Joann E, MEIGS, James B, WATERS, Kevin, MUKAMAL, Kenneth J, SPENCER, Kylee L, PENDERGRASS, Sarah A, SHRADER, Peter, WILKENS, Lynne R, HINDORFF, Lucia A, LUIS AMBITE, Jose, NORTH, Kari E, PETERS, Ulrike, CRAWFORD, Dana C, LE MARCHAND, Loic, PANKOW, James S, BUZKOVA, Petra, SAROJA VORUGANTI, V, WAN, Peggy, HAESSLER, Jeff, FRANCESCHINI, Nora, MONROE, Kristine R, HOWARD, Barbara V

“…Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the…”
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Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration by GAOFENG WANG, SPENCER, Kylee L, POLK, Monica, AGARWAL, Anita, POSTEL, Eric A, HAINES, Jonathan L, PERICAK-VANCE, Margaret A, SCOTT, William K, WHITEHEAD, Patrice, COURT, Brenda L, AYALA-HAEDO, Juan, MAYO, Ping, SCHWARTZ, Stephen G, KOVACH, Jaclyn L, GALLINS, Paul

“…Controversy remains as to which gene at the chromosome 10q26 locus confers risk for age-related macular degeneration (AMD) and statistical genetic analysis is…”
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The ARMS2 A69S variant and bilateral advanced age-related macular degeneration by Schwartz, Stephen G, Agarwal, Anita, Kovach, Jaclyn L, Gallins, Paul J, Cade, William, Postel, Eric A, Wang, Gaofeng, Ayala-Haedo, Juan, Spencer, Kylee M, Haines, Jonathan L, Pericak-Vance, Margaret A, Scott, William K

“…To identify genetic associations between specific risk genes and bilateral advanced age-related macular degeneration (AMD) in a retrospective, observational…”
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Independent Effects of Complement Factor H Y402H Polymorphism and Cigarette Smoking on Risk of Age-Related Macular Degeneration by Scott, William K., PhD, Schmidt, Silke, PhD, Hauser, Michael A., PhD, Gallins, Paul, MS, Schnetz-Boutaud, Nathalie, PhD, Spencer, Kylee L., BA, Gilbert, John R., PhD, Agarwal, Anita, MD, Postel, Eric A., MD, Haines, Jonathan L., PhD, Pericak-Vance, Margaret A., PhD

“…Objective To examine the potential gene–environment interaction between cigarette smoking and the complement factor H (CFH) T1277C polymorphism, 2 strong risk…”
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Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study by Fesinmeyer, Megan D, Meigs, James B, North, Kari E, Schumacher, Fredrick R, Bůžková, Petra, Franceschini, Nora, Haessler, Jeffrey, Goodloe, Robert, Spencer, Kylee L, Voruganti, Venkata Saroja, Howard, Barbara V, Jackson, Rebecca, Kolonel, Laurence N, Liu, Simin, Manson, JoAnn E, Monroe, Kristine R, Mukamal, Kenneth, Dilks, Holli H, Pendergrass, Sarah A, Nato, Andrew, Wan, Peggy, Wilkens, Lynne R, Le Marchand, Loic, Ambite, José Luis, Buyske, Steven, Florez, Jose C, Crawford, Dana C, Hindorff, Lucia A, Haiman, Christopher A, Peters, Ulrike, Pankow, James S

“…Multiple genome-wide association studies (GWAS) within European populations have implicated common genetic variants associated with insulin and glucose…”
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Bringing the genetics of macular degeneration into focus by Haines, Jonathan L, Spencer, Kylee M, Pericak-Vance, Margaret A

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