Search Results - "Spencer, Kevin"

Neuronal imbalance of excitation and inhibition in schizophrenia: a scoping review of gamma‐band ASSR findings by Onitsuka, Toshiaki, Tsuchimoto, Rikako, Oribe, Naoya, Spencer, Kevin M., Hirano, Yoji

“…Recent empirical findings suggest that altered neural synchronization, which is hypothesized to be associated with an imbalance of excitatory (E) and…”
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Spontaneous Gamma Activity in Schizophrenia by Hirano, Yoji, Oribe, Naoya, Kanba, Shigenobu, Onitsuka, Toshiaki, Nestor, Paul G, Spencer, Kevin M

“…A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to…”
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Baseline gamma power during auditory steady-state stimulation in schizophrenia by Spencer, Kevin M

“…Several studies have reported deficits in γ oscillatory activity elicited by sensory stimulation or cognitive processes in schizophrenia patients (SZ) compared…”
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Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants by Spencer, Kevin C., Sy, Jay C., Ramadi, Khalil B., Graybiel, Ann M., Langer, Robert, Cima, Michael J.

“…Glial scar is a significant barrier to neural implant function. Micromotion between the implant and tissue is suspected to be a key driver of glial scar…”
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Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia by Spencer, Kevin M, Niznikiewicz, Margaret A, Nestor, Paul G, Shenton, Martha E, McCarley, Robert W

“…Oscillatory electroencephalogram (EEG) abnormalities may reflect neural circuit dysfunction in neuropsychiatric disorders. Previously we have found positive…”
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Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia by Khadimallah, Ines, Jenni, Raoul, Cabungcal, Jan-Harry, Cleusix, Martine, Fournier, Margot, Beard, Elidie, Klauser, Paul, Knebel, Jean-François, Murray, Micah M., Retsa, Chrysa, Siciliano, Milena, Spencer, Kevin M., Steullet, Pascal, Cuenod, Michel, Conus, Philippe, Do, Kim Q.

“…Early detection and intervention in schizophrenia requires mechanism-based biomarkers that capture neural circuitry dysfunction, allowing better patient…”
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Aneuploidy screening in the first trimester by Spencer, Kevin

“…This article reviews the performance of first trimester screening for chromosomal anomalies using various combinations of ultrasound and maternal serum…”
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Growth of human breast tissues from patient cells in 3D hydrogel scaffolds by Sokol, Ethan S, Miller, Daniel H, Breggia, Anne, Spencer, Kevin C, Arendt, Lisa M, Gupta, Piyush B

“…Three-dimensional (3D) cultures have proven invaluable for expanding human tissues for basic research and clinical applications. In both contexts, 3D cultures…”
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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology by Javitt, Daniel C, Siegel, Steven J, Spencer, Kevin M, Mathalon, Daniel H, Hong, L Elliot, Martinez, Antigona, Ehlers, Cindy L, Abbas, Atheir I, Teichert, Tobias, Lakatos, Peter, Womelsdorf, Thilo

“…New treatment development for psychiatric disorders depends critically upon the development of physiological measures that can accurately translate between…”
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The contribution of gamma bursting to spontaneous gamma activity in schizophrenia by Spencer, Kevin M, Nakhnikian, Alexander, Hirano, Yoji, Levin, Margaret

“…Increased spontaneous gamma (30-100 Hz) activity (SGA) has been reported in the auditory cortex in schizophrenia. This phenomenon has been correlated with…”
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Neurophysiological biomarkers for drug development in schizophrenia by Hajós, Mihály, Javitt, Daniel C, Spencer, Kevin M, Thaker, Gunvant K, Winterer, Georg

“…Key Points Patients with schizophrenia show numerous aberrant neurophysiological signals that reflect abnormal brain functions. Recent advances in…”
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The role of maternal serum α-fetoprotein in screening for open spina bifida at 11-13 weeks by Spencer, Kevin, DSc

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The functional consequences of cortical circuit abnormalities on gamma oscillations in schizophrenia: insights from computational modeling by Spencer, Kevin M

“…Schizophrenia is characterized by cortical circuit abnormalities, which might be reflected in gamma-frequency (30-100 Hz) oscillations in the…”
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Position statement from the Chromosome Abnormality Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis by Benn, Peter, Borrell, Antoni, Chiu, Rossa W. K., Cuckle, Howard, Dugoff, Lorraine, Faas, Brigitte, Gross, Susan, Huang, Tianhua, Johnson, Joann, Maymon, Ron, Norton, Mary, Odibo, Anthony, Schielen, Peter, Spencer, Kevin, Wright, Dave, Yaron, Yuval

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γ-Band Auditory Steady-State Responses Are Impaired in First Episode Psychosis by Spencer, Kevin M, Salisbury, Dean F, Shenton, Martha E, McCarley, Robert W

“…Background In chronic schizophrenia and chronic bipolar disorder, γ band (30–100 Hz) auditory steady-state electroencephalogram responses (ASSRs) are reduced…”
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Optogenetic manipulation of an ascending arousal system tunes cortical broadband gamma power and reveals functional deficits relevant to schizophrenia by McNally, James M., Aguilar, David D., Katsuki, Fumi, Radzik, Leana K., Schiffino, Felipe L., Uygun, David S., McKenna, James T., Strecker, Robert E., Deisseroth, Karl, Spencer, Kevin M., Brown, Ritchie E.

“…Increases in broadband cortical electroencephalogram (EEG) power in the gamma band (30–80 Hz) range have been observed in schizophrenia patients and in mouse…”
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Spectral decomposition of resting state electroencephalogram reveals unique theta/alpha activity in schizophrenia by Nakhnikian, Alexander, Oribe, Naoya, Hirano, Shogo, Fujishima, Yuki, Hirano, Yoji, Nestor, Paul G., Francis, Grace A., Levin, Margaret, Spencer, Kevin M.

“…Resting state electroencephalographic (EEG) activity in schizophrenia (SZ) is frequently characterised by increased power at slow frequencies and/or a…”
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Time to Be Spontaneous: A Renaissance of Intrinsic Brain Activity in Psychosis Research? by Spencer, Kevin M

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Language-Related Neurophysiological Deficits in Schizophrenia by Hirano, Shogo, Spencer, Kevin M., Onitsuka, Toshiaki, Hirano, Yoji

“…Schizophrenia is a severe psychiatric disorder that affects all aspects of one’s life with several cognitive and social dysfunctions. However, there is still…”
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Long-range synchrony of gamma oscillations and auditory hallucination symptoms in schizophrenia by Mulert, C., Kirsch, V., Pascual-Marqui, Roberto, McCarley, Robert W., Spencer, Kevin M.

“…Phase locking in the gamma-band range has been shown to be diminished in patients with schizophrenia. Moreover, there have been reports of positive…”
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