Search Results - "Spencer, Jeffrey"

Deep mutational scanning of S. pyogenes Cas9 reveals important functional domains by Spencer, Jeffrey M., Zhang, Xiaoliu

“…RNA-guided endonucleases (RGENs) have invigorated the field of site-specific nucleases. The success of Streptococcus pyogenes Cas9 (SpCas9) has led to the…”
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Writing Assignments to Support the Learning Goals of a CURE by Watts, Field M, Spencer, Jeffrey L, Shultz, Ginger V

“…Course-based undergraduate research experiences (CUREs) are purported to support a range of learning objectives and outcomes for students. Pedagogical…”
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Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field by Paffett-Lugassy, Noelle, Novikov, Natasha, Jeffrey, Spencer, Abrial, Maryline, Guner-Ataman, Burcu, Sakthivel, Srinivasan, Burns, Caroline E, Burns, C Geoffrey

“…During mammalian embryogenesis, cardiac progenitor cells constituting the second heart field (SHF) give rise to the right ventricle and primitive outflow tract…”
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A Nuclear Magnetic Resonance Solvent Impurity Jigsaw-Style Activity for Undergraduate Organic Chemistry Students by Boothe, Jordan R., Spencer, Jeffrey L., Shultz, Ginger V.

“…A cooperative-learning jigsaw-style activity was developed to create opportunities for introductory organic chemistry students to discuss and decipher 1H NMR…”
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A universal deep-learning model for zinc finger design enables transcription factor reprogramming by Ichikawa, David M., Abdin, Osama, Alerasool, Nader, Kogenaru, Manjunatha, Mueller, April L., Wen, Han, Giganti, David O., Goldberg, Gregory W., Adams, Samantha, Spencer, Jeffrey M., Razavi, Rozita, Nim, Satra, Zheng, Hong, Gionco, Courtney, Clark, Finnegan T., Strokach, Alexey, Hughes, Timothy R., Lionnet, Timothee, Taipale, Mikko, Kim, Philip M., Noyes, Marcus B.

“…Cys 2 His 2 zinc finger (ZF) domains engineered to bind specific target sequences in the genome provide an effective strategy for programmable regulation of…”
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Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation by Abrial, Maryline, Basu, Sandeep, Huang, Mengmeng, Butty, Vincent, Schwertner, Asya, Jeffrey, Spencer, Jordan, Daniel, Burns, Caroline E, Burns, C Geoffrey

“…Aortic root aneurysm is a common cause of morbidity and mortality in Loeys-Dietz and Marfan syndromes, where perturbations in transforming growth factor beta…”
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Engineered dual selection for directed evolution of SpCas9 PAM specificity by Goldberg, Gregory W., Spencer, Jeffrey M., Giganti, David O., Camellato, Brendan R., Agmon, Neta, Ichikawa, David M., Boeke, Jef D., Noyes, Marcus B.

“…The widely used Streptococcus pyogenes Cas9 (SpCas9) nuclease derives its DNA targeting specificity from protein-DNA contacts with protospacer adjacent motif…”
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GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling by White, Mark A, Tsouko, Efrosini, Lin, Chenchu, Rajapakshe, Kimal, Spencer, Jeffrey M, Wilkenfeld, Sandi R, Vakili, Sheiva S, Pulliam, Thomas L, Awad, Dominik, Nikolos, Fotis, Katreddy, Rajasekhara Reddy, Kaipparettu, Benny Abraham, Sreekumar, Arun, Zhang, Xiaoliu, Cheung, Edwin, Coarfa, Cristian, Frigo, Daniel E

“…Despite altered metabolism being an accepted hallmark of cancer, it is still not completely understood which signaling pathways regulate these processes. Given…”
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Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3 by Fielitz, Jens, Kim, Mi-Sung, Shelton, John M, Latif, Shuaib, Spencer, Jeffrey A, Glass, David J, Richardson, James A, Bassel-Duby, Rhonda, Olson, Eric N

“…Maintenance of skeletal and cardiac muscle structure and function requires precise control of the synthesis, assembly, and turnover of contractile proteins of…”
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A Guided-Inquiry Activity for Introducing Students to Figures from Primary Scientific Literature by Maxwell, Danielle N., Spencer, Jeffrey L., Teich, Ethan A., Cooke, Madeline, Fromwiller, Braeden, Peterson, Nathan, Nicholas-Figueroa, Linda, Shultz, Ginger V., Pratt, Kerri A.

“…Reading and understanding scientific literature is an essential skill for any scientist to learn. While students’ scientific literacy can be improved by…”
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Elastic fiber homeostasis requires lysyl oxidase-like 1 protein by Li, Tiansen, Liu, Xiaoqing, Zhao, Yun, Gao, Jiangang, Pawlyk, Basil, Starcher, Barry, Spencer, Jeffrey A, Yanagisawa, Hiromi, Zuo, Jian

“…Elastic fibers are components of the extracellular matrix and confer resilience. Once laid down, they are thought to remain stable, except in the uterine tract…”
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Agonists of the tissue-protective erythropoietin receptor in the treatment of Parkinson's disease by Punnonen, Juha, Miller, James L, Collier, Timothy J, Spencer, Jeffrey R

“…Parkinson's disease (PD) is a neurodegenerative disease affecting more than a million people in the USA alone. While there are effective symptomatic treatments…”
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Cultural Relevance in Chemistry Education: Snow Chemistry and the Iñupiaq Community by Spencer, Jeffrey L, Maxwell, Danielle N, Erickson, Kaare Ray Sikuaq, Wall, Daniel, Nicholas-Figueroa, Linda, Pratt, Kerri A, Shultz, Ginger V

“…U.S. education generally portrays science from the Western perspective. As a result, students from different cultures, also referred to as nonmajority…”
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Chemistry Instructional Coaching: Adapting a Peer-Led Professional Development Program for Chemistry Graduate Teaching Assistants by Fantone, Rebecca C., Zaimi, Ina, Meserve, Krista, Geragosian, Eleni K., Álvarez-Sánchez, Christian O., Spencer, Jeffrey L., Shultz, Ginger V.

“…Graduate teaching assistants (GTAs) are crucial facilitators of undergraduate education, yet many begin their teaching appointments with minimal knowledge of…”
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The geometric influence on the Cys2His2 zinc finger domain and functional plasticity by Mueller, April L, Corbi-Verge, Carles, Giganti, David O, Ichikawa, David M, Spencer, Jeffrey M, MacRae, Mark, Garton, Michael, Kim, Philip M, Noyes, Marcus B

“…Abstract The Cys2His2 zinc finger is the most common DNA-binding domain expanding in metazoans since the fungi human split. A proposed catalyst for this…”
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Erythropoietin and small molecule agonists of the tissue-protective erythropoietin receptor increase FXN expression in neuronal cells in vitro and in Fxn-deficient KIKO mice in vivo by Miller, James L., Rai, Myriam, Frigon, Normand L., Pandolfo, Massimo, Punnonen, Juha, Spencer, Jeffrey R.

“…Friedreich's ataxia (FA) is a progressive neurodegenerative disease caused by reduced levels of the mitochondrial protein frataxin (FXN). Recombinant human…”
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Corrigendum to “Primary testicular teratoid Wilms tumor in a 40-year-old male with retroperitoneal lymph node involvement: A case report” [Urol Case Rep (March 2024) 102701] by Arbel, Eylon J., Dinerman, Brian F., Rutkowski, John, Acosta, Andrés M., Spencer, Jeffrey

“…[This corrects the article DOI: 10.1016/j.eucr.2024.102701.]…”
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Primary testicular teratoid Wilms tumor in a 40-year-old male with retroperitoneal lymph node involvement: A case report by Arbel, Eylon J., Dinerman, Brian F., Rutkowski, John, Acosta, Andrés M., Spencer, Jeffrey

“…We report a 40-year-old male presenting with right testicular pain and swelling for several months. Following right orchiectomy demonstrating pT1bS0N0M0…”
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Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor by Miller, James L, Church, Timothy J, Leonoudakis, Dmitri, Lariosa-Willingham, Karen, Frigon, Normand L, Tettenborn, Connie S, Spencer, Jeffrey R, Punnonen, Juha

“…Erythropoietin (EPO) and its receptor are expressed in a wide variety of tissues, including the central nervous system. Local expression of both EPO and its…”
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TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation by Abrial, Maryline, Paffett-Lugassy, Noëlle, Jeffrey, Spencer, Jordan, Daniel, O’Loughlin, Evan, Frederick, Charles J., Burns, C. Geoffrey, Burns, Caroline E.

“…The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although…”
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