Search Results - "Spencer, Gary J"

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells by Harris, William J., Huang, Xu, Lynch, James T., Spencer, Gary J., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Miller, Crispin J., Ogilvie, Donald J., Somervaille, Tim C.P.

“…Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem…”
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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia by Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.

“…Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that…”
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Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia by Somerville, Tim D.D., Wiseman, Daniel H., Spencer, Gary J., Huang, Xu, Lynch, James T., Leong, Hui Sun, Williams, Emma L., Cheesman, Edmund, Somervaille, Tim C.P.

“…Through in silico and other analyses, we identified FOXC1 as expressed in at least 20% of human AML cases, but not in normal hematopoietic populations. FOXC1…”
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Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia by Simeoni, Fabrizio, Romero-Camarero, Isabel, Camera, Francesco, Amaral, Fabio M.R., Sinclair, Oliver J., Papachristou, Evangelia K., Spencer, Gary J., Lie-A-Ling, Michael, Lacaud, Georges, Wiseman, Daniel H., Carroll, Jason S., Somervaille, Tim C.P.

“…Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of…”
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Expression Profiling and Functional Analysis of Wnt Signaling Mechanisms in Mesenchymal Stem Cells by Etheridge, S. Leah, Spencer, Gary J., Heath, Deborah J., Genever, Paul G.

“…Through their broad differentiation potential, mesenchymal stem cells (MSCs) are candidates for a range of therapeutic applications, but the precise signaling…”
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Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia by Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.

“…The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous system, limb buds, and heart, and transcript levels specify…”
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LSD1 inhibitors disrupt the GFI1 transcription repressor complex by Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.

“…Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this…”
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Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia by Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.

“…Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid…”
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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies by Nicosia, Luciano, Spencer, Gary J, Brooks, Nigel, Amaral, Fabio M R, Basma, Naseer J, Chadwick, John A, Revell, Bradley, Wingelhofer, Bettina, Maiques-Diaz, Alba, Sinclair, Oliver, Camera, Francesco, Ciceri, Filippo, Wiseman, Daniel H, Pegg, Neil, West, Will, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Campbell, Victoria L, Cavet, James, Copland, Mhairi, Searle, Emma, Somervaille, Tim C P

“…CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hematologic malignancy model…”
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Climatic influences on basal metabolic rates among circumpolar populations by Leonard, William R., Sorensen, Mark V., Galloway, Victoria A., Spencer, Gary J., Mosher, M.J., Osipova, Ludmilla, Spitsyn, Victor A.

“…This article examines evidence for elevations in basal metabolic rate (BMR) among indigenous Northern (circumpolar) populations and considers potential…”
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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia by Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.

“…The histone demethylase lysine-specific demethylase 1 (LSD1 or KDM1A) has emerged as a candidate therapeutic target in acute myeloid leukaemia (AML);…”
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Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells by SOMERVAILLE, Tim C. P, MATHENY, Christina J, SPENCER, Gary J, IWASAKI, Masayuki, RINN, John L, WITTEN, Daniela M, CHANG, Howard Y, SHURTLEFF, Sheila A, DOWNING, James R, CLEARY, Michael L

“…The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are…”
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HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block by Maiques-Diaz, Alba, Nicosia, Luciano, Basma, Naseer J., Romero-Camarero, Isabel, Camera, Francesco, Spencer, Gary J., Amaral, Fabio M. R., Simeoni, Fabrizio, Wingelhofer, Bettina, Williamson, Andrew J. K., Pierce, Andrew, Whetton, Anthony D., Somervaille, Tim C. P.

“…Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene…”
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Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro by Spencer, Gary J., Utting, Jennifer C., Etheridge, Sharon L., Arnett, Timothy R., Genever, Paul G.

“…Reports implicating Wnt signalling in the regulation of bone mass have prompted widespread interest in the use of Wnt mimetics for the treatment of skeletal…”
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Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells by Jones, Stuart, Ahmet, Jonathan, Ayton, Kelly, Ball, Matthew, Cockerill, Mark, Fairweather, Emma, Hamilton, Nicola, Harper, Paul, Hitchin, James, Jordan, Allan, Levy, Colin, Lopez, Ruth, McKenzie, Eddie, Packer, Martin, Plant, Darren, Simpson, Iain, Simpson, Peter, Sinclair, Ian, Somervaille, Tim C. P, Small, Helen, Spencer, Gary J, Thomson, Graeme, Tonge, Michael, Waddell, Ian, Walsh, Jarrod, Waszkowycz, Bohdan, Wigglesworth, Mark, Wiseman, Daniel H, Ogilvie, Donald

“…A collaborative high throughput screen of 1.35 million compounds against mutant (R132H) isocitrate dehydrogenase IDH1 led to the identification of a novel…”
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Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1 by Mould, Daniel P., Bremberg, Ulf, Jordan, Allan M., Geitmann, Matthis, McGonagle, Alison E., Somervaille, Tim C.P., Spencer, Gary J., Ogilvie, Donald J.

“…[Display omitted] As part of our ongoing efforts to develop reversible inhibitors of LSD1, we identified a series of 4-(pyrrolidin-3-yl)benzonitrile…”
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Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1 by Mould, Daniel P, Alli, Cristina, Bremberg, Ulf, Cartic, Sharon, Jordan, Allan M, Geitmann, Matthis, Maiques-Diaz, Alba, McGonagle, Alison E, Somervaille, Tim C. P, Spencer, Gary J, Turlais, Fabrice, Ogilvie, Donald

“…Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differentiation of leukemia stem cells in acute myeloid leukemia (AML)…”
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Current perspectives on NMDA-type glutamate signalling in bone by Spencer, Gary J., McGrath, Catherine J., Genever, Paul G.

“…Bone is a complex, evolving tissue, architecturally defined by the activities of osteoclasts and osteoblasts that continually resorb and replace the…”
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Emerging neuroskeletal signalling pathways: a review by Spencer, Gary J, Hitchcock, Ian S, Genever, Paul G

“…Recent work has demonstrated that neurotransmitters, signalling molecules primarily associated with the nervous system, can have profound effects on the…”
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CCS1477, a Novel p300/CBP Bromodomain Inhibitor, Enhances Efficacy of Azacitidine and Venetoclax in Pre-Clinical Models of Acute Myeloid Leukaemia and Lymphoma by Brooks, Nigel, Knurowski, Tomasz, Hughes, Andrew, Clegg, Karen, West, William, Pegg, Neil A, Spencer, Gary J, Chadwick, John, Somervaille, Tim C.P

“…E1A binding protein (p300) and CREB binding protein (CBP) are two closely related histone acetyl transferases that co-activate key oncogenes such as MYC and…”
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