Search Results - "Spencer, Damian M"

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis by Parakh, Sonam, Jagaraj, Cyril J, Vidal, Marta, Ragagnin, Audrey M G, Perri, Emma R, Konopka, Anna, Toth, Reka P, Galper, Jasmin, Blair, Ian P, Thomas, Colleen J, Walker, Adam K, Yang, Shu, Spencer, Damian M, Atkin, Julie D

“…Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder and mutations in superoxide dismutase 1 (SOD1) account for 20% of familial…”
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Redox Regulation in Amyotrophic Lateral Sclerosis by Parakh, Sonam, Spencer, Damian M., Halloran, Mark A., Soo, Kai Y., Atkin, Julie D.

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results from the death of upper and lower motor neurons. Due to a lack of effective…”
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Caspase-2: controversial killer or checkpoint controller by Kitevska, Tanja, Spencer, Damian M. S, Hawkins, Christine J

“…The caspases are an evolutionarily conserved family of cysteine proteases, with essential roles in apoptosis or inflammation. Caspase-2 was the second caspase…”
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The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models by Parakh, Sonam, Shadfar, Sina, Perri, Emma R., Ragagnin, Audrey M.G., Piattoni, Claudia V., Fogolín, Mariela B., Yuan, Kristy C., Shahheydari, Hamideh, Don, Emily K., Thomas, Collen J., Hong, Yuning, Comini, Marcelo A., Laird, Angela S., Spencer, Damian M., Atkin, Julie D.

“…Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in almost all cases of amyotrophic lateral sclerosis (ALS), and 20% of familial ALS cases…”
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The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration by Perri, Emma R, Thomas, Colleen J, Parakh, Sonam, Spencer, Damian M, Atkin, Julie D

“…The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons and its dysregulation is increasingly implicated in…”
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Formaldehyde-releasing prodrugs in combination with adriamycin can overcome cellular drug resistance by Cutts, Suzanne M, Nudelman, Abraham, Pillay, Vinochani, Spencer, Damian M S, Levovich, Inesa, Rephaeli, Ada, Phillips, Don R

“…The anticancer drug Adriamycin is widely used in cancer chemotherapy and is classified as a topoisomerase II inhibitor. However, in the presence of…”
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DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair by Spencer, Damian M S, Bilardi, Rebecca A, Koch, Tad H, Post, Glen C, Nafie, Jordan W, Kimura, Ken-Ichi, Cutts, Suzanne M, Phillips, Don R

“…Doxorubicin, a widely used anthracycline anticancer agent, acts as a topoisomerase II poison but can also form formaldehyde-mediated DNA adducts. This has led…”
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Detection of labile anthracycline-DNA adducts by real-time PCR by Spencer, Damian M S, Cutts, Suzanne M, Kimura, Ken-ichi, Gray, Peter J, Phillips, Don R

“…Barminomycin was employed as a model anthracycline that yields thermally stable drug-DNA adducts. Real-time PCR was utilized for the detection of these…”
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