Search Results - "Spence, Patrick"

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel by Dallal Bashi, Yahya H., Murphy, Diarmaid J., McCoy, Clare F., Boyd, Peter, Brown, Leeanne, Kihara, Matthew, Martin, François, McMullen, Nicole, Kleinbeck, Kyle, Dangi, Bindi, Spence, Patrick, Hansraj, Bashir, Devlin, Brid, Malcolm, R. Karl

“…A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose…”
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In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel by Murphy, Diarmaid J., Dallal Bashi, Yahya H., McCoy, Clare F., Boyd, Peter, Brown, Leeanne, Martin, François, McMullen, Nicole, Kleinbeck, Kyle, Dangi, Bindi, Spence, Patrick, Hansraj, Bashir, Devlin, Bríd, Malcolm, R. Karl

“…We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a…”
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Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings by McCoy, Clare F., Spence, Patrick, Dallal Bashi, Yahya H., Murphy, Diarmaid J., Boyd, Peter, Dangi, Bindi, Derrick, Tiffany, Devlin, Bríd, Kleinbeck, Kyle, Malcolm, R. Karl

“…Vaginal rings releasing antiretrovirals – either alone or in combination with contraceptive progestins – are being developed for prevention of human…”
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Engineering New Branches of the Kynurenine Pathway To Produce Oxo-(2-aminophenyl) and Quinoline Scaffolds in Yeast by Torrens-Spence, Michael Patrick, Liu, Chun-Ting, Weng, Jing-Ke

“…The kynurenine pathway, named after its nonproteinogenic amino acid precursor l-kynurenine, is responsible for the de novo biosynthesis of nicotinamide adenine…”
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Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women by Nel, Annalene, van Niekerk, Neliëtte, Kapiga, Saidi, Bekker, Linda-Gail, Gama, Cynthia, Gill, Katherine, Kamali, Anatoli, Kotze, Philip, Louw, Cheryl, Mabude, Zonke, Miti, Nokuthula, Kusemererwa, Sylvia, Tempelman, Hugo, Carstens, Hannelie, Devlin, Brid, Isaacs, Michelle, Malherbe, Mariëtte, Mans, Winel, Nuttall, Jeremy, Russell, Marisa, Ntshele, Smangaliso, Smit, Marlie, Solai, Leonard, Spence, Patrick, Steytler, John, Windle, Kathleen, Borremans, Maarten, Resseler, Sophie, Van Roey, Jens, Parys, Wim, Vangeneugden, Tony, Van Baelen, Ben, Rosenberg, Zeda

“…Preventing HIV-1 infection, especially with female-controlled approaches, is a high priority. In this trial in South Africa and Uganda, a dapivirine vaginal…”
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BAP1 loss defines a new class of renal cell carcinoma by Peña-Llopis, Samuel, Vega-Rubín-de-Celis, Silvia, Liao, Arnold, Leng, Nan, Pavía-Jiménez, Andrea, Wang, Shanshan, Yamasaki, Toshinari, Zhrebker, Leah, Sivanand, Sharanya, Spence, Patrick, Kinch, Lisa, Hambuch, Tina, Jain, Suneer, Lotan, Yair, Margulis, Vitaly, Sagalowsky, Arthur I, Summerour, Pia Banerji, Kabbani, Wareef, Wong, S W Wendy, Grishin, Nick, Laurent, Marc, Xie, Xian-Jin, Haudenschild, Christian D, Ross, Mark T, Bentley, David R, Kapur, Payal, Brugarolas, James

“…James Brugarolas and colleagues identify recurrent BAP1 mutations in clear cell renal cell carcinoma (ccRCC). They show that BAP1 binds to HCF-1 and suppresses…”
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In vitro release testing methods for drug-releasing vaginal rings by Boyd, Peter, Variano, Bruce, Spence, Patrick, McCoy, Clare F., Murphy, Diarmaid J., Dallal Bashi, Yahya H., Malcolm, R. Karl

“…[Display omitted] Drug-releasing vaginal rings are torus-shaped devices, generally fabricated from thermoplastic polymers or silicone elastomers, used to…”
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Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions by Murphy, Diarmaid J., McCoy, Clare F., Boyd, Peter, Derrick, Tiffany, Spence, Patrick, Devlin, Brid, Malcolm, R. Karl

“…[Display omitted] In two recent Phase III clinical trials, use of a 25 mg dapivirine vaginal ring significantly reduced HIV acquisition rates. Post hoc…”
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Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence by Spence, Patrick, Nel, Annalene, van Niekerk, Neliëtte, Derrick, Tiffany, Wilder, Susan, Devlin, Bríd

“…•Simulated use of dapivirine VRs showed no content changes after storage at RT or −20°C.•On average, about 4mg of dapivirine is released in vivo after 28 days…”
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Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers by Dallal Bashi, Yahya H., McCoy, Clare F., Murphy, Diarmaid J., Boyd, Peter, Spence, Patrick, Kleinbeck, Kyle, Devlin, Bríd, Malcolm, R. Karl

“…[Display omitted] With a dapivirine-releasing vaginal ring having successfully completed late-stage clinical testing for HIV prevention and currently…”
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Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma by Tran, Tram Anh, Leong, Hon Sing, Pavia-Jimenez, Andrea, Fedyshyn, Slavic, Yang, Juan, Kucejova, Blanka, Sivanand, Sharanya, Spence, Patrick, Xie, Xian-Jin, Peña-Llopis, Samuel, Power, Nicholas, Brugarolas, James

“…Antiangiogenic therapies, such as sunitinib, have revolutionized renal cell carcinoma (RCC) treatment. However, a precarious understanding of how resistance…”
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A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma by Sivanand, Sharanya, Peña-Llopis, Samuel, Zhao, Hong, Kucejova, Blanka, Spence, Patrick, Pavia-Jimenez, Andrea, Yamasaki, Toshinari, McBride, David J, Gillen, Jessica, Wolff, Nicholas C, Morlock, Lorraine, Lotan, Yair, Raj, Ganesh V, Sagalowsky, Arthur, Margulis, Vitaly, Cadeddu, Jeffrey A, Ross, Mark T, Bentley, David R, Kabbani, Wareef, Xie, Xian-Jin, Kapur, Payal, Williams, Noelle S, Brugarolas, James

“…Most anticancer drugs entering clinical trials fail to achieve approval from the U.S. Food and Drug Administration. Drug development is hampered by the lack of…”
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Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring by McCoy, Clare F, Murphy, Diarmaid J, Boyd, Peter, Derrick, Tiffany, Spence, Patrick, Devlin, Brid, Malcolm, R Karl

“…A silicone elastomer vaginal ring providing sustained release over 28 days of the anti-retroviral microbicide dapivirine has recently completed phase III…”
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Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States by Liu, Albert Y, Dominguez Islas, Clara, Gundacker, Holly, Neradilek, Blazej, Hoesley, Craig, van der Straten, Ariane, Hendrix, Craig W, Beamer, May, Jacobson, Cindy E, McClure, Tara, Harrell, Tanya, Bunge, Katherine, Devlin, Brid, Nuttall, Jeremy, Spence, Patrick, Steytler, John, Piper, Jeanna M, Marzinke, Mark A

“…Introduction Vaginal rings are a promising approach to provide a woman‐centred, long‐acting HIV prevention strategy. Prior trials of a 25 mg dapivirine (DPV)…”
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Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance by Murphy, Diarmaid J., Lim, Deanna, Armstrong, Ryan, McCoy, Clare F., Bashi, Yahya H. Dallal, Boyd, Peter, Derrick, Tiffany, Spence, Patrick, Devlin, Bríd, Malcolm, R. Karl

“…Previously reported in vitro release test methods for drug-releasing vaginal rings containing poorly water-soluble drugs have described use of water-alcohol…”
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Recent work on vaginal rings containing antiviral agents for HIV prevention by Spence, Patrick, Bhatia Garg, Anita, Woodsong, Cynthia, Devin, Brid, Rosenberg, Zeda

“…PURPOSE OF REVIEWIn response to the need for strategies women can use to protect themselves from HIV infection, a new class of product commonly referred to as…”
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Parental Involvement in the Lives of College Students: Impact on Student Independence, Self-Direction, and Critical Thinking by Spence, Patrick

“…Recent studies have noted the increasing communication between parents and students while students are in college (College Parent, 2007; Hofer & Moore, 2010)…”
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Erratum: BAP1 loss defines a new class of renal cell carcinoma by Peña-Llopis, Samuel, Vega-Rubín-de-Celis, Silvia, Liao, Arnold, Leng, Nan, Pavía-Jiménez, Andrea, Wang, Shanshan, Yamasaki, Toshinari, Zhrebker, Leah, Sivanand, Sharanya, Spence, Patrick, Kinch, Lisa, Hambuch, Tina, Jain, Suneer, Lotan, Yair, Margulis, Vitaly, Sagalowsky, Arthur I, Summerour, Pia Banerji, Kabbani, Wareef, Wong, S W Wendy, Grishin, Nick, Laurent, Marc, Xie, Xian-Jin, Haudenschild, Christian D, Ross, Mark T, Bentley, David R, Kapur, Payal, Brugarolas, James

“…Nat. Genet. 44, 751–759 (2012); published online 10 June 2012; corrected after print 21 June 2012 In the version of this article initially published, the P…”
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Chiral recognition in the solid state: crystallographically characterized diastereomeric co-crystals between a synthetic chiral selector (Whelk-O1) and a representative chiral analyte by Koscho, Michael E., Spence, Patrick L., Pirkle, William H.

“…Designed to distinguish between the enantiomers of compounds possessing commonly occurring structural features, the chiral selector used in the chiral…”
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BAP 1 loss defines a new class of renal cell carcinoma by PENA-LLOPIS, Samuel, VEGA-RUBIN-DE-CELIS, Silvia, KINCH, Lisa, HAMBUCH, Tina, JAIN, Suneer, LOTAN, Yair, MARGULIS, Vitaly, SAGALOWSKY, Arthur I, SUMMEROUR, Pia Banerji, KABBANI, Wareef, WENDY WONG, S. W, GRISHIN, Nick, LIAO, Arnold, LAURENT, Marc, XIE, Xian-Jin, HAUDENSCHILD, Christian D, ROSS, Mark T, BENTLEY, David R, KAPUR, Payal, BRUGAROLAS, James, NAN LENG, FAVIA-JIMENEZ, Andrea, SHANSHAN WANG, YAMASAKI, Toshinari, ZHREBKER, Leah, SIVANAND, Sharanya, SPENCE, Patrick

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