Search Results - "Spence, M.W."

Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin by Glanville, N T, Byers, D M, Cook, H W, Spence, M W, Palmer, F B

“…Phosphoinositide and inositol metabolism was compared in glioma (C6), neuroblastoma (N1E-115) and neuroblastoma X glioma hybrid (NG 108-15) cells. All cell…”
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Pharmacokinetics and bioavailability of diisopropanolamine (DIPA) in rats following intravenous or dermal application by Saghir, S.A., Frantz, S.W., Spence, M.W., Nolan, R.J., Lowe, E.R., Rick, D.L., Bartels, M.J.

“…This study was conducted to determine the relative dermal bioavailability (absorption), distribution, metabolism, and excretion (ADME) of diisopropanolamine…”
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Channeling of intermediates in the CDP-choline pathway of phosphatidylcholine biosynthesis in cultured glioma cells is dependent on intracellular Ca2 by GEORGE, T. P, COOK, H. W, BYERS, D. M, PALMER, F. B. S. C, SPENCE, M. W

“…The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline…”
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Calcium-independent effects of TMB-8 : modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake by PALMER, F. B. S. C, BYERS, D. M, SPENCE, M.W, COOK, H. W

“…TMB-8 [8-(NN-diethylamino)-octyl-3,4,5-trimethoxybenzoate] blocks agonist-stimulated release of Ca2+ from intracellular sites in many cell lines and is often…”
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Interaction of (n−3) and (n−6) fatty acids in desaturation and chain elongation of essential fatty acids in cultured glioma cells by Cook, Harold W., Spence, Matthew W.

“…Recent research in various biological systems has revived interest in interactions between the (n−6) and (n−3) essential fatty acids. We have utilized cultured…”
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Isolation of plasma membranes from cultured glioma cells and application to evaluation of membrane sphingomyelin turnover by Cook, H W, Palmer, F B, Byers, D M, Spence, M W

“…A rapid and reliable method for the isolation of plasma membranes and microsomes of high purity and yield from cultured glioma cells is described. The…”
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Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates by George, T P, Morash, S C, Cook, H W, Byers, D M, Palmer, F B, Spence, M W

“…The major pathway of choline (Cho) incorporation into phosphatidylcholine (PtdCho) in mammalian cells is sequential conversion of Cho to phosphocholine (PCho),…”
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Incorporation of polyunsaturated fatty acids into plasmalogens, compared to other phospholipids of cultured glioma cells, is more dependent on chain length than on selectivity between (n - 3) and (n - 6) families by Thomas, S E, Byers, D M, Palmer, F B, Spence, M W, Cook, H W

“…In several tissues and cells, polyunsaturated fatty acids (PUFA) are esterified to plasmalogens (1-O-alk-1'-enyl-2-acyl-sn-glycero-3 phosphoethanolamine). Some…”
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Limited metabolic interaction of serine with ethanolamine and choline in the turnover of phosphatidylserine, phosphatidylethanolamine and plasmalogens in cultured glioma cells by Xu, Z, Byers, D M, Palmer, F B, Spence, M W, Cook, H W

“…Modulation of choline phosphoglyceride turnover has been investigated extensively but less is known about regulation of serine and ethanolamine…”
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Studies on the turnover and subcellular localization of membrane gangliosides in cultured neuroblastoma cells by CLARKE, J. T. R, COOK, H. W, SPENCE, M. W

“…To compare the subcellular distribution of endogenously synthesized and exogenous gangliosides, cultured murine neuroblastoma cells (N1E-115) were incubated in…”
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Evaluation of the cost-effectiveness of various passive monitors and active monitors for industrial hygiene sampling by Nothstein, G L, Hahne, R M, Spence, M W

“…A framework for evaluating passive or active industrial hygiene air sampling monitors on a cost-effectiveness basis is described. Five passive monitors and one…”
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Polyunsaturated fatty acid incorporation into plasmalogens in plasma membrane of glioma cells is preceded temporally by acylation in microsomes by Thomas, S E, Morris, S J, Xu, Z, Byers, D M, Palmer, F B, Spence, M W, Cook, H W

“…Plasmalogens (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamine) are major phospholipids in many tissues and cells, particularly of neural origin. Using…”
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Biodegradation of o-phenylphenol in river water and activated sludge by Gonsior, S.J, Bailey, R.E, Rhinehart, W.L, Spence, M.W

“…Initial concentrations of o-phenylphenol (OPP) in river water were 123, 12.3 and 1.22 ug per litre and in activated sludge, 9.6 mg per litre. OPP and its…”
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Stimulation of neutral, magnesium-stimulated sphingomyelinase activity in the neurohypophysis of the rat by hypertonic saline ingestion by Guy, N C, Clarke, J T, Spence, M W, Cook, H W

“…Neutral, magnesium-stimulated sphingomyelinase and acid sphingomyelinase activities in the neurohypophysis, adenohypophysis and cerebrum of rats given 2.25%…”
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Inborn errors of metabolism in the Maritimes, with special reference to maple-syrup-urine disease and Fabry's disease by Spence, M W, Dewolfe, M S

“…1. The study of inborn errors of metabolism in man is of wide, general relevance to human biology and medicine, because these derangements are unique human…”
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Measurement of organic vapors at sub-TLV concentrations using fast gas chromatography by Mouradian, R F, Levine, S P, Sacks, R D, Spence, M W

“…Gas chromatography usually is considered too slow a method to be useful for real-time or near real-time monitoring. If the chromatographic system is optimized…”
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