Search Results - "Spellman, S"

Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain by Hanamura, Kenji, Washburn, Halley R, Sheffler-Collins, Sean I, Xia, Nan L, Henderson, Nathan, Tillu, Dipti V, Hassler, Shayne, Spellman, Daniel S, Zhang, Guoan, Neubert, Thomas A, Price, Theodore J, Dalva, Matthew B

“…Extracellular phosphorylation of proteins was suggested in the late 1800s when it was demonstrated that casein contains phosphate. More recently, extracellular…”
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A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults by Aliprantis, Antonios O., Shaw, Christine A., Griffin, Paul, Farinola, Nicholas, Railkar, Radha A., Cao, Xin, Liu, Wen, Sachs, Jeffrey R., Swenson, Christine J., Lee, Heather, Cox, Kara S., Spellman, Daniel S., Winstead, Colleen J., Smolenov, Igor, Lai, Eseng, Zaks, Tal, Espeseth, Amy S., Panther, Lori

“…Respiratory Syncytial Virus (RSV) causes lower respiratory tract infections that can be severe and sometimes fatal. The risk for severe RSV infection is…”
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Validation of a multiplexed and targeted lipidomics assay for accurate quantification of lipidomes by Zhang, Nanyan Rena, Hatcher, Nathan G., Ekroos, Kim, Kedia, Komal, Kandebo, Monika, Marcus, Jacob N., Smith, Sean M., Bateman, Kevin P., Spellman, Daniel S.

“…A major challenge of lipidomics is to determine and quantify the precise content of complex lipidomes to the exact lipid molecular species. Often, multiple…”
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Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac by Deinhardt, Katrin, Kim, Taeho, Spellman, Daniel S, Mains, Richard E, Eipper, Betty A, Neubert, Thomas A, Chao, Moses V, Hempstead, Barbara L

“…Growth of axons and dendrites is a dynamic process that involves guidance molecules, adhesion proteins, and neurotrophic factors. Although neurite extension is…”
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Quantification of tau in cerebrospinal fluid by immunoaffinity enrichment and tandem mass spectrometry by McAvoy, Thomas, Lassman, Michael E, Spellman, Daniel S, Ke, Zhenlian, Howell, Bonnie J, Wong, Oitak, Zhu, Lan, Tanen, Michael, Struyk, Arie, Laterza, Omar F

“…Cerebrospinal fluid (CSF) tau is a common biomarker for Alzheimer disease (AD). Measurements of tau have historically been performed using immunoassays. Given…”
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Revealing complete complex KIR haplotypes phased by long-read sequencing technology by Roe, D, Vierra-Green, C, Pyo, C-W, Eng, K, Hall, R, Kuang, R, Spellman, S, Ranade, S, Geraghty, D E, Maiers, M

“…The killer cell immunoglobulin-like receptor (KIR) region of human chromosome 19 contains up to 16 genes for natural killer (NK) cell receptors that recognize…”
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Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF by Spellman, Daniel S., Wildsmith, Kristin R., Honigberg, Lee A., Tuefferd, Marianne, Baker, David, Raghavan, Nandini, Nairn, Angus C., Croteau, Pascal, Schirm, Michael, Allard, Rene, Lamontagne, Julie, Chelsky, Daniel, Hoffmann, Steven, Potter, William Z.

“…Purpose We describe the outcome of the Biomarkers Consortium CSF Proteomics Project (where CSF is cerebral spinal fluid), a public–private partnership of…”
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Generic Automated Method for Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry Based Monoclonal Antibody Quantitation for Preclinical Pharmacokinetic Studies by Zhang, Qian, Spellman, Daniel S., Song, Yaoli, Choi, Bernard, Hatcher, Nathan G., Tomazela, Daniela, Beaumont, Maribel, Tabrizifard, Mohammad, Prabhavalkar, Deepa, Seghezzi, Wolfgang, Harrelson, Jane, Bateman, Kevin P.

“…Quantitation of therapeutic monoclonal antibodies (mAb) using liquid chromatography–tandem mass spectrometry (LC–MS/MS) for pharmacokinetic (PK) studies is…”
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Improving the throughput of immunoaffinity purification and enzymatic digestion of therapeutic proteins using membrane-immobilized reagent technology by Robinson, Michelle R, Vasicek, Lisa A, Hoppmann, Christian, Li, Mandy, Jokhadze, Gia, Spellman, Daniel S

“…Continued interest in protein therapeutics has motivated the development of improved bioanalytical tools to support development programs. LC-MS offers…”
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Direct quantitation of therapeutic antibodies for pharmacokinetic studies using immuno-purification and intact mass analysis by Vasicek, Lisa A, Zhu, Xin, Spellman, Daniel S, Bateman, Kevin P

“…The quantitation of therapeutic antibodies by MS often utilizes a surrogate peptide approach. Recent enhancements in instrumentation and sample preparation…”
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Proteomic Discovery and Validation of Novel Fluid Biomarkers for Improved Patient Selection and Prediction of Clinical Outcomes in Alzheimer’s Disease Patient Cohorts by Awasthi, Shivangi, Spellman, Daniel S, Hatcher, Nathan G

“…Alzheimer’s disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline. The two cardinal neuropathological…”
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Correction: Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain by Hanamura, Kenji, Washburn, Halley R., Sheffler-Collins, Sean I., Xia, Nan L., Henderson, Nathan, Tillu, Dipti V., Hassler, Shayne, Spellman, Daniel S., Zhang, Guoan, Neubert, Thomas A., Price, Theodore J., Dalva, Matthew B.

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Unrelated donor search prognostic score to support early HLA consultation and clinical decisions by Wadsworth, K, Albrecht, M, Fonstad, R, Spellman, S, Maiers, M, Dehn, J

“…A simple scoring system that can provide a quick search prognosis at the onset of an adult unrelated donor (URD) search could be a useful tool for transplant…”
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GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes by Chen, Y-B, Wang, T, Hemmer, M T, Brady, C, Couriel, D R, Alousi, A, Pidala, J, Urbano-Ispizua, A, Choi, S W, Nishihori, T, Teshima, T, Inamoto, Y, Wirk, B, Marks, D I, Abdel-Azim, H, Lehmann, L, Yu, L, Bitan, M, Cairo, M S, Qayed, M, Salit, R, Gale, R P, Martino, R, Jaglowski, S, Bajel, A, Savani, B, Frangoul, H, Lewis, I D, Storek, J, Askar, M, Kharfan-Dabaja, M A, Aljurf, M, Ringden, O, Reshef, R, Olsson, R F, Hashmi, S, Seo, S, Spitzer, T R, MacMillan, M L, Lazaryan, A, Spellman, S R, Arora, M, Cutler, C S

“…Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, we analyzed 1404 umbilical cord blood transplantation (UCBT)…”
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Quantitative analysis of intact apolipoproteins in human HDL by top-down differential mass spectrometry by Mazur, Matthew T, Cardasis, Helene L, Spellman, Daniel S, Liaw, Andy, Yates, Nathan A, Hendrickson, Ronald C

“…Top-down mass spectrometry holds tremendous potential for the characterization and quantification of intact proteins, including individual protein isoforms and…”
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Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis by Maas, Brian M., Lommerse, Jos, Plock, Nele, Railkar, Radha A., Cheung, S.Y. Amy, Caro, Luzelena, Chen, Jingxian, Liu, Wen, Zhang, Ying, Huang, Qinlei, Gao, Wei, Qin, Li, Meng, Jie, Witjes, Han, Schindler, Emilie, Guiastrennec, Benjamin, Bellanti, Francesco, Spellman, Daniel S., Roadcap, Brad, Kalinova, Mariya, Fok-Seang, Juin, Catchpole, Andrew P., Espeseth, Amy S., Stoch, S. Aubrey, Lai, Eseng, Vora, Kalpit A., Aliprantis, Antonios O., Sachs, Jeffrey R.

“…Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb)…”
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Novel HLA-DP region susceptibility loci associated with severe acute GvHD by Goyal, R K, Lee, S J, Wang, T, Trucco, M, Haagenson, M, Spellman, S R, Verneris, M, Ferrell, R E

“…Despite HLA allele matching, significant acute GvHD remains a major barrier to successful unrelated donor BMT. We conducted a genome-wide association study…”
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Limited HLA sequence variation outside of antigen recognition domain exons of 360 10 of 10 matched unrelated hematopoietic stem cell transplant donor‐recipient pairs by Hou, L., Vierra‐Green, C., Lazaro, A., Brady, C., Haagenson, M., Spellman, S., Hurley, C. K.

“…Traditional DNA‐based typing focuses primarily on interrogating the exons of human leukocyte antigen (HLA) genes that form the antigen recognition domain…”
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Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1 by Fleischhauer, K, Fernandez-Viña, M A, Wang, T, Haagenson, M, Battiwalla, M, Baxter-Lowe, L A, Ciceri, F, Dehn, J, Gajewski, J, Hale, G A, Heemskerk, M B A, Marino, S R, McCarthy, P L, Miklos, D, Oudshoorn, M, Pollack, M S, Reddy, V, Senitzer, D, Shaw, B E, Waller, E K, Lee, S J, Spellman, S R

“…HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each…”
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Directionality of non-permissive HLA-DPB1 T-cell epitope group mismatches does not improve clinical risk stratification in 8/8 matched unrelated donor hematopoietic cell transplantation by Fleischhauer, K, Ahn, K W, Wang, H L, Zito, L, Crivello, P, Müller, C, Verneris, M, Shaw, B E, Pidala, J, Oudshorn, M, Lee, S J, Spellman, S R

“…In 8/8 HLA-matched unrelated donor (UD) hematopoietic cell transplants (HCT), HLA-DPB1 mismatches between alleles from different T-cell epitope (TCE) groups…”
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