Search Results - "Spellman, PT"

Abstract ES8-2: Modeling Sensitivity to Therapeutic Agents by Spellman, PT

“…Abstract Single agent targeted chemotherapeutics are now being deployed with the goal of revolutionizing clinical treatments. It is likely that many of these…”
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The Toll and Imd pathways are the major regulators of the immune response in Drosophila by De Gregorio, Ennio, Spellman, Paul T., Tzou, Phoebe, Rubin, Gerald M., Lemaitre, Bruno

“…Microarray studies have shown recently that microbial infection leads to extensive changes in the Drosophila gene expression programme. However, little is…”
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Genome-Wide Analysis of the Drosophila Immune Response by Using Oligonucleotide Microarrays by De Gregorio, Ennio, Spellman, Paul T., Rubin, Gerald M., Lemaitre, Bruno

“…To identify new Drosophila genes involved in the immune response, we monitored the gene expression profile of adult flies in response to microbial infection by…”
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Cluster analysis and display of genome-wide expression patterns by Eisen, M.B. (Howard Hughes Medical Institute, Stanford, CA.), Spellman, P.T, Brown, P.O, Botstein, D

“…A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to…”
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Genomic expression programs in the response of yeast cells to environmental changes by Gasch, A P, Spellman, P T, Kao, C M, Carmel-Harel, O, Eisen, M B, Storz, G, Botstein, D, Brown, P O

“…We explored genomic expression patterns in the yeast Saccharomyces cerevisiae responding to diverse environmental transitions. DNA microarrays were used to…”
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Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization by Spellman, P T, Sherlock, G, Zhang, M Q, Iyer, V R, Anders, K, Eisen, M B, Brown, P O, Botstein, D, Futcher, B

“…We sought to create a comprehensive catalog of yeast genes whose transcript levels vary periodically within the cell cycle. To this end, we used DNA…”
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The Stanford Microarray Database by Sherlock, G, Hernandez-Boussard, T, Kasarskis, A, Binkley, G, Matese, J C, Dwight, S S, Kaloper, M, Weng, S, Jin, H, Ball, C A, Eisen, M B, Spellman, P T, Brown, P O, Botstein, D, Cherry, J M

“…The Stanford Microarray Database (SMD) stores raw and normalized data from microarray experiments, and provides web interfaces for researchers to retrieve,…”
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Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth by Futcher, Bruce, Zhu, Gefeng, Spellman, Paul T, Volpe, Tom, Brown, Patrick O, Botstein, David, Davis, Trisha N

“…There are about 800 genes in Saccharomyces cerevisiae whose transcription is cell-cycle regulated. Some of these form clusters of co-regulated genes. The…”
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The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism by Pile, Lori A, Spellman, Paul T, Katzenberger, Rebeccah J, Wassarman, David A

“…Deacetylation of histones by the SIN3 complex is a major mechanism utilized in eukaryotic organisms to repress transcription. Presumably, developmental and…”
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P1-06-22: Identification of Biomarkers in Breast Cancer for Prediction of Response to PARP Inhibitor Olaparib by Daemen, A, Wolf, DM, Korkola, JE, Griffith, OL, Frankum, JR, Jakkula, LR, Wang, NJ, Natrajan, R, Reis-Filho, JS, Lord, CJ, Ashworth, A, Gray, JW, Spellman, PT, van't Veer, L

“…Abstract Background: Poly (ADP-ribose) polymerase (PARP) is an enzyme involved in DNA repair. PARP inhibitors operate on the principle of synthetic lethality…”
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Reply: whole-culture synchronization – effective tools for cell cycle studies by Spellman, Paul T, Sherlock, Gavin

“…Studies of gene expression during the eukaryotic cell cycle in whole-culture synchronized cultures have been published using many methodologies. These…”
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Ceramic capillaries for use in microarray fabrication by George, R A, Woolley, J P, Spellman, P T

“…We have used ceramic capillary tips generally used in the microelectronics industry for the production of DNA microarrays. The ceramic tips improve the…”
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