Search Results - "Spellberg, Brad"

Duration of Antibiotic Therapy: Shorter Is Better by Spellberg, Brad, Rice, Louis B

“…Spellberg and Rice offer insights on the duration of antibiotic therapy. Society continues to face a crisis of antibiotic resistance, caused largely by the…”
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Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges by Wong, Darren, Nielsen, Travis B, Bonomo, Robert A, Pantapalangkoor, Paul, Luna, Brian, Spellberg, Brad

“…SUMMARYAcinetobacter is a complex genus, and historically, there has been confusion about the existence of multiple species. The species commonly cause…”
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Sustainable Discovery and Development of Antibiotics — Is a Nonprofit Approach the Future? by Nielsen, Travis B, Brass, Eric P, Gilbert, David N, Bartlett, John G, Spellberg, Brad

“…Shifting to a nonprofit-driven model for development of antibiotics could encourage discovery and development of truly needed drugs that improve patient…”
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SERPINB1-mediated checkpoint of inflammatory caspase activation by Choi, Youn Jung, Kim, Stephanie, Choi, Younho, Nielsen, Travis B., Yan, Jun, Lu, Alvin, Ruan, Jianbin, Lee, Hye-Ra, Wu, Hao, Spellberg, Brad, Jung, Jae U.

“…Inflammatory caspases (caspase-1, caspase-4, caspase-5 and caspase-11 (caspase-1/-4/-5/-11)) mediate host defense against microbial infections, processing…”
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Defining the Breakpoint Duration of Staphylococcus aureus Bacteremia Predictive of Poor Outcomes by Minejima, Emi, Mai, Nikki, Bui, Nancy, Mert, Melissa, Mack, Wendy J, She, Rosemary C, Nieberg, Paul, Spellberg, Brad, Wong-Beringer, Annie

“…Abstract Background Persistent Staphylococcus aureus bacteremia (SAB) is defined based on varying duration in literature. The primary objective was to…”
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S1497 Optimizing Percutaneous Endoscopic Gastrostomy Tube Placement Wait Times in a Safety Net Hospital by Yeh, Jeffrey, Ayyala-Somayajula, Divya, Spellberg, Brad, Sahakian, Ara B., Phan, Jennifer, Buxbaum, James L.

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Capsule carbohydrate structure determines virulence in Acinetobacter baumannii by Talyansky, Yuli, Nielsen, Travis B, Yan, Jun, Carlino-Macdonald, Ulrike, Di Venanzio, Gisela, Chakravorty, Somnath, Ulhaq, Amber, Feldman, Mario F, Russo, Thomas A, Vinogradov, Evgeny, Luna, Brian, Wright, Meredith S, Adams, Mark D, Spellberg, Brad

“…Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen for which novel therapeutic approaches are needed. Unfortunately, the drivers of…”
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The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial by Spellberg, Brad, Ibrahim, Ashraf S., Chin-Hong, Peter V., Kontoyiannis, Dimitrios P., Morris, Michele I., Perfect, John R., Fredricks, David, Brass, Eric P.

“…Objectives Host iron availability is fundamental to mucormycosis pathogenesis. The combination of liposomal amphotericin B (LAmB) and deferasirox iron…”
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Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management by SPELLBERG, Brad, EDWARDS, John JR, IBRAHIM, Ashraf

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates by Lu, Peggy, Alletto, Francesco, Lee, Bosul, Burk, Elizabeth, Martinez, Jasmine, Prati, Fabio, Caselli, Emilia, Spellberg, Brad, Luna, Brian

“…Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also…”
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Combination Polyene-Caspofungin Treatment of Rhino-Orbital-Cerebral Mucormycosis by Reed, Caitlin, Bryant, Richard, Ibrahim, Ashraf S., Edwards, John, Filler, Scott G., Goldberg, Robert, Spellberg, Brad

“…Background. It has been axiomatic that echinocandins (e.g., caspofungin) are ineffective against mucormycosis. However, on the basis of preclinical data, we…”
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Novel insights into disseminated candidiasis: pathogenesis research and clinical experience converge by Spellberg, Brad

“…In some of these models immunosuppression of the colonized animals led to dissemination, but the immunosuppression was generally with agents that…”
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Recent Advances in the Management of Mucormycosis: From Bench to Bedside by Goldstein, Ellie J. C., Spellberg, Brad, Walsh, Thomas J., Kontoyiannis, Dimitrios P., Edwards, John, Ibrahim, Ashraf S.

“…Recent therapeutic advances have the potential to improve outcomes of mucormycosis. Lipid formulations of amphotericin B (LFAB) have evolved as the cornerstone…”
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Horizontal Gene Transfer of Antibiotic Resistance from Acinetobacter baylyi to Escherichia coli on Lettuce and Subsequent Antibiotic Resistance Transmission to the Gut Microbiome by Maeusli, Marlène, Lee, Bosul, Miller, Sarah, Reyna, Zeferino, Lu, Peggy, Yan, Jun, Ulhaq, Amber, Skandalis, Nicholas, Spellberg, Brad, Luna, Brian

“…Agricultural use of antibiotics is recognized by the U.S. Centers for Disease Control and Prevention as a major contributor to antibiotic-resistant infections…”
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Molecular Epidemiology of Carbapenem-Nonsusceptible Acinetobacter baumannii in the United States by ADAMS-HADUCH, Jennifer M, ONUOHA, Ezenwa O, DOI, Yohei, BOGDANOVICH, Tatiana, TIAN, Guo-Bao, MARSCHALL, Jonas, URBAN, Carl M, SPELLBERG, Brad J, RHEE, Diane, HALSTEAD, Diane C, PASCULLE, Anthony W

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Monoclonal Antibody Requires Immunomodulation for Efficacy Against Acinetobacter baumannii Infection by Nielsen, Travis B, Yan, Jun, Luna, Brian M, Talyansky, Yuli, Slarve, Matthew, Bonomo, Robert A, Spellberg, Brad

“…Abstract Monoclonal antibodies (mAbs) are gaining significant momentum as novel therapeutics for infections caused by antibiotic-resistant bacteria. We…”
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The iron chelator deferasirox protects mice from mucormycosis through iron starvation by Ibrahim, Ashraf S, Gebermariam, Teclegiorgis, Fu, Yue, Lin, Lin, Husseiny, Mohamed I, French, Samuel W, Schwartz, Julie, Skory, Christopher D, Edwards, Jr, John E, Spellberg, Brad J

“…Mucormycosis causes mortality in at least 50% of cases despite current first-line therapies. Clinical and animal data indicate that the presence of elevated…”
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Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice by Lin, Lin, Ibrahim, Ashraf S, Xu, Xin, Farber, Joshua M, Avanesian, Valentina, Baquir, Beverlie, Fu, Yue, French, Samuel W, Edwards, Jr, John E, Spellberg, Brad

“…We sought to define protective mechanisms of immunity to Staphylococcus aureus and Candida albicans bloodstream infections in mice immunized with the…”
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Combination Therapy for Mucormycosis: Why, What, and How? by Spellberg, Brad, Ibrahim, Ashraf, Roilides, Emmanuel, Lewis, Russel E., Lortholary, Olivier, Petrikkos, George, Kontoyiannis, Dimitrios P., Walsh, Thomas J.

“…The high mortality rate of mucormycosis with currently available monotherapy, particularly in hematology patients, has stimulated interest in studying novel…”
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Reducing Clostridium difficile Colitis Rates Via Cost-Saving Diagnostic Stewardship by Yen, Christina, Holtom, Paul, Butler-Wu, Susan M, Wald-Dickler, Noah, Shulman, Ira, Spellberg, Brad

“…We conducted a quality improvement project at a large public tertiary-care academic hospital to reduce reported hospital-acquired Clostridium difficile…”
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