Bifunctional RNA‐Targeting Deoxyribozyme Nanodevice as a Potential Theranostic Agent

Bifunctional RNA‐Targeting Deoxyribozyme Nanodevice as a Potential Theranostic Agent

Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High selectivity of RNA target recognition under near phys...

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Bibliographic Details
Published in:Chemistry : a European journal Vol. 26; no. 16; pp. 3489 - 3493
Main Authors: Spelkov, Aleksandr A., Goncharova, Ekaterina A., Savin, Artemii M., Kolpashchikov, Dmitry M.
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 18-03-2020
Subjects:
binary probes
Chemistry
Deoxyribonucleic acid
deoxyribozymes
Diagnostic systems
DNA
DNA, Catalytic - chemistry
DNA, Catalytic - genetics
DNA, Catalytic - metabolism
Fluorescence
Humans
Nanotechnology devices
Neoplasms - chemistry
Neoplasms - genetics
Ribonucleic acid
RNA
RNA - chemistry
RNA - metabolism
RNA recognition
Selectivity
Target recognition
Theranostic Nanomedicine
theranostics
Therapy
Virus Diseases - diagnosis
RNA recognition
theranostics
binary probes
fluorescence
DNA
deoxyribozymes
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Summary:Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High selectivity of RNA target recognition under near physiological conditions was achieved. The proposed approach can become a basis for the design of DNA nanomachines and robots for diagnostics and therapy of viral infections, cancer, and genetic disorders. Two birds with one stone: A DNA association can complete both RNA‐cleaving (therapeutic) and RNA‐detecting (diagnostic) functions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201905528