Search Results - "Speina, Elzbieta"

Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes by Tudek, Barbara, Zdżalik-Bielecka, Daria, Tudek, Agnieszka, Kosicki, Konrad, Fabisiewicz, Anna, Speina, Elżbieta

“…Exocyclic adducts to DNA bases are formed as a consequence of exposure to certain environmental carcinogens as well as inflammation and lipid peroxidation…”
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5,6-diiodo-1H-benzotriazole: new TBBt analogue that minutely affects mitochondrial activity by Paprocki, Daniel, Winiewska-Szajewska, Maria, Speina, Elżbieta, Kucharczyk, Róża, Poznański, Jarosław

“…4,5,6,7-Tetrabromo-1 H -benzotriazole is widely used as the reference ATP-competitive inhibitor of protein kinase CK2. Herein, we study its new analogs:…”
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Synthesis of Novel Halogenated Heterocycles Based on o-Phenylenediamine and Their Interactions with the Catalytic Subunit of Protein Kinase CK2 by Winiewska-Szajewska, Maria, Maciejewska, Agnieszka Monika, Speina, Elżbieta, Poznański, Jarosław, Paprocki, Daniel

“…Protein kinase CK2 is a highly pleiotropic protein kinase capable of phosphorylating hundreds of protein substrates. It is involved in numerous cellular…”
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Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy by Shahmoradi Ghahe, Somayeh, Kosicki, Konrad, Wojewódzka, Maria, Majchrzak, Bartosz A., Fogtman, Anna, Iwanicka-Nowicka, Roksana, Ciuba, Agata, Koblowska, Marta, Kruszewski, Marcin, Tudek, Barbara, Speina, Elżbieta

“…[Display omitted] •Increased capacity of anti-ROS mechanisms in PDT-resistant cells.•Higher activity of DNA repair and ATM kinase in PDT resistant glioblastoma…”
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Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile by Mieczkowski, Adam, Speina, Elżbieta, Trzybiński, Damian, Winiewska-Szajewska, Maria, Wińska, Patrycja, Borsuk, Ewelina M, Podsiadła-Białoskórska, Małgorzata, Przygodzki, Tomasz, Drabikowski, Krzysztof, Stanczyk, Lidia, Zhukov, Igor, Watala, Cezary, Woźniak, Krzysztof

“…Phosphodiesterase 5 (PDE5) is one of the most extensively studied phosphodiesterases that is highly specific for cyclic-GMP hydrolysis. PDE5 became a target…”
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DNA damage, repair and the improvement of cancer therapy – A tribute to the life and research of Barbara Tudek by Tudek, Agnieszka, Czerwińska, Jolanta, Kosicki, Konrad, Zdżalik-Bielecka, Daria, Shahmoradi Ghahe, Somayeh, Bażlekowa-Karaban, Milena, Borsuk, Ewelina M., Speina, Elżbieta

“…[Display omitted] •The manuscript is dedicated to Barbara Tudek, EEMGS FH Sobels Award 2019 Winner.•Repair of 8-OxoGua and etheno adducts may serve as cancer…”
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Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal by Czerwińska, Jolanta, Poznański, Jarosław, Dębski, Janusz, Bukowy, Zuzanna, Bohr, Vilhelm A, Tudek, Barbara, Speina, Elżbieta

“…4-Hydroxy-2-nonenal (HNE) is a reactive α,β-unsaturated aldehyde generated during oxidative stress and subsequent peroxidation of polyunsaturated fatty acids…”
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ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation by Czerwińska, Jolanta, Nowak, Małgorzata, Wojtczak, Patrycja, Dziuban-Lech, Dorota, Cieśla, Jarosław M., Kołata, Daria, Gajewska, Beata, Barańczyk-Kuźma, Anna, Robinson, Andria R., Shane, Hillary L., Gregg, Siobhán Q., Rigatti, Lora H., Yousefzadeh, Matthew J., Gurkar, Aditi U., McGowan, Sara J., Kosicki, Konrad, Bednarek, Małgorzata, Zarakowska, Ewelina, Gackowski, Daniel, Oliński, Ryszard, Speina, Elżbieta, Niedernhofer, Laura J., Tudek, Barbara

“…Lipid peroxidation (LPO) products are relatively stable and abundant metabolites, which accumulate in tissues of mammals with aging, being able to modify all…”
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Direct and indirect roles of RECQL4 in modulating base excision repair capacity by Schurman, Shepherd H., Hedayati, Mohammad, Wang, ZhengMing, Singh, Dharmendra K., Speina, Elzbieta, Zhang, Yongqing, Becker, Kevin, Macris, Margaret, Sung, Patrick, Wilson, David M., Croteau, Deborah L., Bohr, Vilhelm A.

“…RECQL4 is a human RecQ helicase which is mutated in approximately two-thirds of individuals with Rothmund–Thomson syndrome (RTS), a disease characterized at…”
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Human RECQL5β stimulates flap endonuclease 1 by Speina, Elżbieta, Dawut, Lale, Hedayati, Mohammad, Wang, ZhengMing, May, Alfred, Schwendener, Sybille, Janscak, Pavel, Croteau, Deborah L, Bohr, Vilhelm A

“…Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of…”
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Aberrant repair of etheno–DNA adducts in leukocytes and colon tissue of colon cancer patients by Obtułowicz, Tomasz, Winczura, Alicja, Speina, Elżbieta, Swoboda, Maja, Janik, Justyna, Janowska, Beata, Cieśla, Jarosław M., Kowalczyk, Paweł, Jawien, Arkadiusz, Gackowski, Daniel, Banaszkiewicz, Zbigniew, Krasnodebski, Ireneusz, Chaber, Andrzej, Olinski, Ryszard, Nair, Jagadesaan, Bartsch, Helmut, Douki, Thierry, Cadet, Jean, Tudek, Barbara

“…To assess the role of lipid peroxidation-induced DNA damage and repair in colon carcinogenesis, the excision rates and levels of 1, N…”
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Acetylation regulates WRN catalytic activities and affects base excision DNA repair by Muftuoglu, Meltem, Kusumoto, Rika, Speina, Elzbieta, Beck, Gad, Cheng, Wen-Hsing, Bohr, Vilhelm A

“…The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been…”
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Contribution of hMTH1 to the Maintenance of 8-Oxoguanine Levels in Lung DNA of Non–Small-Cell Lung Cancer Patients by Speina, Elżbieta, Arczewska, Katarzyna D., Gackowski, Daniel, Zielińska, Maja, Siomek, Agnieszka, Kowalewski, Janusz, Oliński, Ryszard, Tudek, Barbara, Kuśmierek, Jarosław T.

“…Background: The level of 8-oxoguanine (8-oxoG), a general marker of oxidative DNA damage, in DNA is the result of both an equilibrium between the rates of its…”
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Oxidatively damaged DNA and its repair in colon carcinogenesis by Tudek, Barbara, Speina, Elżbieta

“…Inflammation, high fat, high red meat and low fiber consumption have for long been known as the most important etiological factors of sporadic colorectal…”
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Dimeric Benzodiazepines as Peptide Mimetics to Overcome p53-Dependent Drug Resistance of Tumors by Speina, Elżbieta, Wilczek, Marcin, Mieczkowski, Adam

“…Benzodiazepines that consist of one α- and one β-amino acid residues linked together in a seven-membered heterocyclic ring could be treated as small, rigid,…”
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8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes by Janik, Justyna, Swoboda, Maja, Janowska, Beata, Cieśla, Jarosław M, Gackowski, Daniel, Kowalewski, Janusz, Olinski, Ryszard, Tudek, Barbara, Speina, Elżbieta

“…Decreased repair of oxidative DNA damage is a risk factor for developing certain human malignancies. We have previously found that the capacity of…”
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Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients by Obtułowicz, Tomasz, Swoboda, Maja, Speina, Elżbieta, Gackowski, Daniel, Rozalski, Rafal, Siomek, Agnieszka, Janik, Justyna, Janowska, Beata, Cieśla, Jarosław M., Jawien, Arkadiusz, Banaszkiewicz, Zbigniew, Guz, Jolanta, Dziaman, Tomasz, Szpila, Anna, Olinski, Ryszard, Tudek, Barbara

“…Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined…”
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Fapyadenine is a moderately efficient chain terminator for prokaryotic DNA polymerases by Grąziewicz, Maria Anna, Zastawny, Tomasz Hubert, Oliński, Ryszard, Speina, Elżbieta, Siedlecki, Janusz, Tudek, Barbara

“…Hypoxanthine\xanthine oxidase\Fe3+\ethylenediaminetetraacetate (EDTA) was used to modify ss M13 mp18 phage DNA. The dominant base modifications found by…”
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Identification of New Genes Regulated by the Crt1 Transcription Factor, an Effector of the DNA Damage Checkpoint Pathway in Saccharomyces cerevisiae by Zaim, Jolanta, Speina, Elżbieta, Kierzek, Andrzej M.

“…The Crt1 (RFX1) protein in Saccharomyces cerevisiae is an effector of the DNA damage checkpoint pathway. It recognizes a 13-bp cis-regulatory element in the…”
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8‐Oxo‐7,8‐dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients by Dziaman, Tomasz, Banaszkiewicz, Zbigniew, Roszkowski, Krzysztof, Gackowski, Daniel, Wisniewska, Ewa, Rozalski, Rafał, Foksinski, Marek, Siomek, Agnieszka, Speina, Elzbieta, Winczura, Alicja, Marszalek, Andrzej, Tudek, Barbara, Olinski, Ryszard

“…The aim of this work was to answer the question whether the broad range of parameters which describe oxidative stress and oxidatively damaged DNA and repair…”
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