Search Results - "Speicher, MR"

The new cytogenetics: blurring the boundaries with molecular biology by Speicher, Michael R, Carter, Nigel P

“…Exciting advances in fluorescence in situ hybridization and array-based techniques are changing the nature of cytogenetics, in both basic research and…”
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The coloring of cytogenetics by Speicher, Michael R, Ward, David C

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Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes by Bolzer, Andreas, Kreth, Gregor, Solovei, Irina, Koehler, Daniela, Saracoglu, Kaan, Fauth, Christine, Müller, Stefan, Eils, Roland, Cremer, Christoph, Speicher, Michael R, Cremer, Thomas

“…Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to explore changes in epigenome structure and their functional…”
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Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia by Mayr, Christine, Speicher, Michael R., Kofler, David M., Buhmann, Raymund, Strehl, John, Busch, Raymonde, Hallek, Michael, Wendtner, Clemens-Martin

“…In chronic lymphocytic leukemia (CLL), chromosomes usually evade detailed cytogenetic analyses because cells poorly respond to the traditionally used set of…”
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Inheritance of Gene Density-Related Higher Order Chromatin Arrangements in Normal and Tumor Cell Nuclei by Cremer, Marion, Küpper, Katrin, Wagler, Babett, Wizelman, Leah, Hase, Johann v., Weiland, Yanina, Kreja, Ludwika, Diebold, Joachim, Speicher, Michael R., Cremer, Thomas

“…A gene density-related difference in the radial arrangement of chromosome territories (CTs) was previously described for human lymphocyte nuclei with gene-poor…”
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Securin Is Required for Chromosomal Stability in Human Cells by Jallepalli, Prasad V., Waizenegger, Irene C., Bunz, Fred, Langer, Sabine, Speicher, Michael R., Peters, Jan-Michael, Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph

“…Abnormalities of chromosome number are the most common genetic aberrations in cancer. The mechanisms regulating the fidelity of mitotic chromosome transmission…”
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Digital Karyotyping by Wang, Tian-Li, Maierhofer, Christine, Speicher, Michael R., Lengauer, Christoph, Vogelstein, Bert, Kinzler, Kenneth W., Velculescu, Victor E.

“…Alterations in the genetic content of a cell are the underlying cause of many human diseases, including cancers. We have developed a method, called digital…”
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Karyotyping human chromosomes by combinatorial multi-fluor FISH by Speicher, Michael R, Ballard, Stephen Gwyn, Ward, David C

“…We have developed epifluorescence filter sets and computer software for the detection and discrimination of 27 different DNA probes hybridized simultaneously…”
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Targeted inactivation of p53 in human cells does not result in aneuploidy by BUNZ, Fred, FAUTH, Christine, SPEICHER, Michael R, DUTRIAUX, Annie, SEDIVY, John M, KINZLER, Kenneth W, VOGELSTEIN, Bert, LENGAUER, Christoph

“…Because p53 mutation and aneuploidy usually coexist, it has been suggested that p53 inactivation leads to aneuploidy. We have rigorously tested this hypothesis…”
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Genomic Profiling of Viable and Proliferative Micrometastatic Cells from Early-Stage Breast Cancer Patients by GANGNUS, Rainer, LANGER, Sabine, BREIT, Elisabeth, PANTEL, Klaus, SPEICHER, Michael R

“…Purpose: Metastases in distant organs are the major cause of death for cancer patients, and bone marrow is a prominent homing organ for early disseminated…”
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Comparative Genomic Hybridization, Loss of Heterozygosity, and DNA Sequence Analysis of Single Cells by Klein, Christoph A., Schmidt-Kittler, Oleg, Schardt, Julian A., Pantel, Klaus, Speicher, Michael R., Riethmüller, Gert

“…A PCR strategy is described for global amplification of DNA from a single eukaryotic cell that enables the comprehensive analysis of the whole genome. By…”
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Analysis of gene expression patterns and chromosomal changes associated with aging by GEIGL, Jochen B, LANGER, Sabine, BARVISCH, Simone, PFLEGHAAR, Katrin, LEDERER, Gaby, SPEICHER, Michael R

“…Age is the largest single risk factor for the development of cancer in mammals. Age-associated chromosomal changes, such as aneuploidy and telomere erosion,…”
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Securin is not required for chromosomal stability in human cells by Pfleghaar, Katrin, Heubes, Simone, Cox, Jürgen, Stemmann, Olaf, Speicher, Michael R

“…Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great…”
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Carcinogen-Specific Induction of Genetic Instability by Bardelli, Alberto, Cahill, Daniel P., Lederer, Gabi, Speicher, Michael R., Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph

“…It has been proposed recently that the type of genetic instability in cancer cells reflects the selection pressures exerted by specific carcinogens. We have…”
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Heterogeneous Proliferative Potential of Occult Metastatic Cells in Bone Marrow of Patients with Solid Epithelial Tumors by Solakoglu, Oender, Maierhofer, Christine, Lahr, Georgia, Breit, Elisabeth, Scheunemann, Peter, Heumos, Isabella, Pichlmeier, Uwe, Schlimok, Günter, Oberneder, Ralph, Köllermann, Manfred W., Köllermann, Jens, Speicher, Michael R., Pantel, Klaus

“…Bone marrow is a major homing site for circulating epithelial tumor cells. The present study was aimed to assess the proliferative capacity of occult…”
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Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation by Jaenisch, Rudolf, Eggan, Kevin, Rode, Anja, Jentsch, Isabell, Samuel, Caroline, Hennek, Thomas, Tintrup, Hartmut, Zevnik, Branko, Erwin, Jennifer, Loring, Janet, Jackson-Grusby, Laurie, Speicher, Michael R, Kuehn, Ralf

“…We have devised a general strategy for producing female mice from 39,X0 embryonic stem (ES) cells derived from male cell lines carrying a targeted mutation of…”
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Crossover frequency and synaptonemal complex length: their variability and effects on human male meiosis by Codina-Pascual, M., Campillo, M., Kraus, J., Speicher, M.R., Egozcue, J., Navarro, J., Benet, J.

“…In this study, immunocytogenetics has been used in combination with the subtelomere-specific multiplex-fluorescent in-situ hybridization (stM-FISH) assay to…”
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The Picmonic(®) Learning System: enhancing memory retention of medical sciences, using an audiovisual mnemonic Web-based learning platform by Yang, Adeel, Goel, Hersh, Bryan, Matthew, Robertson, Ron, Lim, Jane, Islam, Shehran, Speicher, Mark R

“…Medical students are required to retain vast amounts of medical knowledge on the path to becoming physicians. To address this challenge, multimedia Web-based…”
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Sequential application of interphase-FISH and CGH to single cells by LANGER, Sabine, GEIGL, Jochen B, GANGNUS, Rainer, SPEICHER, Michael R

“…A comprehensive genomic analysis of single cells is needed for numerous scenarios in tumor genetics, clinical diagnostics and forensic application. PCR…”
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Hyper-recombination and genetic instability in BLM-deficient epithelial cells by TRAVERSO, Giovanni, BETTEGOWDA, Chetan, KRAUS, Jürgen, SPEICHER, Michael R, KINZLER, Kenneth W, VOGELSTEIN, Bert, LENGAUER, Christoph

“…Genetic instability appears to be required for a normal colorectal epithelial cell to evolve into a cancerous one. Bloom syndrome patients have a strong…”
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