Search Results - "Speel, E.J.M."

Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC) by Hermans, B.C.M., Derks, J.L., Thunnissen, E., van Suylen, R.J., den Bakker, M.A., Groen, H.J.M., Smit, E.F., Damhuis, R.A., van den Broek, E.C., Stallinga, C.M., Roemen, G.M., Speel, E.J.M., Dingemans, A.-M.C.

“…•PD-L1 ≥ 1% is expressed in 16% of stage IV LCNEC, 5% has expression ≥50%.•PD-L1 staining in LCNEC is comparable to values in SCLC, but lower than in NSCLC.•No…”
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Chromosome instability predicts the progression of premalignant oral lesions by Siebers, T.J.H, Bergshoeff, V.E, Otte-Höller, I, Kremer, B, Speel, E.J.M, van der Laak, J.A.W.M, Merkx, M.A.W, Slootweg, P.J

“…Summary Objectives One of the main problems in reducing the incidence of oral squamous cell carcinoma (OSCC) is the inability to appropriately deal with…”
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Bone invasion by oral squamous cell carcinoma: essential molecular alterations by Vaassen, L.A.A, Speel, E.J.M, Kessler, P.A.W.H

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Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery by BODE-LESNIEWSKA, B, ZHAO, J, SPEEL, E. J. M, BIRAIMA, A. M, TURINA, M, KOMMINOTH, P, HEITZ, P. U

“…The characterization of clinical, histopathological, immunohistochemical, and genetic features of intimal sarcomas arising in the pulmonary artery is presented…”
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Radiological follow-up in patients with resected pulmonary carcinoids: Should we reduce radiation exposure? by Heijboer, F.W.J., Mulders, T.A., van Straten, M., Moonen, L., Speel, E.J.M., von der Thüsen, J.H., Derks, J.L., Dingemans, A.C.

“…•Resected TC patients at 30y or younger had an additional lifetime cancer risk up to 3.1 % (ENETS) at 40y.•Less extensive radiological follow-up for young TC…”
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Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non-Small Cell Lung Cancer by van der Wekken, A J, Pelgrim, R, 't Hart, N, Werner, N, Mastik, M F, Hendriks, L, van der Heijden, E H F M, Looijen-Salamon, M, de Langen, A J, Staal-van den Brekel, J, Riemersma, S, van den Borne, B E, Speel, E J M, Dingemans, A-M C, Hiltermann, T J N, van den Berg, A, Timens, W, Schuuring, E, Groen, H J M

“…ALK rearrangement detection using FISH is the standard test to identify patients with non-small cell lung carcinoma (NSCLC) eligible for treatment with ALK…”
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Pulmonary neuroendocrine neoplasms with well differentiated morphology and high proliferative activity: illustrated by a case series and review of the literature by Hermans, B.C.M., Derks, J.L., Moonen, L., Habraken, C.H.J., der Thüsen, J. von, Hillen, L.M., Speel, E.J.M., Dingemans, A-M.C.

“…•Carcinoids are characterized by well differentiated morphology and low proliferation.•LCNEC is characterized by poorly differentiated morphology and high…”
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DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile by Hermans, B.C.M., Derks, J.L., Thunnissen, E., van Suylen, R.J., den Bakker, M.A., Groen, H.J.M., Smit, E.F., Damhuis, R.A., van den Broek, E.C., Ruland, A., Speel, E.J.M., Dingemans, A.M.C.

“…•DLL3 is expressed in 74% of stage IV LCNEC patients•The majority (80%) has cytoplasmic/membranous expression•DLL3 is expressed in both SCLC- and NSCLC-like…”
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Exploring imaging features of molecular subtypes of large cell neuroendocrine carcinoma (LCNEC) by Hermans, B.C.M., Sanduleanu, S., Derks, J.L., Woodruff, H., Hillen, L.M., Casale, R., Hoesein, F. Mohamed, de Jong, E., Berge, D.M.H.J. ten, Speel, E.J.M., Lambin, P., Gietema, H.A., Dingemans, A-M.C.

“…•LCNEC has radiological characteristics of both SCLC and NSCLC.•LCNEC can be classified in molecular SCLC-like and NSCLC-like subtypes.•Molecular LCNEC…”
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Rapid bright-field detection of oligonucleotide primed in situ (PRINS)-labeled DNA in chromosome preparations and frozen tissue sections by Speel, E J, Lawson, D, Ramaekers, F C, Gosden, J R, Hopman, A H

“…We describe a new application of a bright-field microscopic procedure for rapid enzyme cytochemical detection of repeated DNA sequences in metaphase…”
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Postzygotic mosaicism in basal cell naevus syndrome by Reinders, M.G.H.C., Boersma, H.J., Leter, E.M., Vreeburg, M., Paulussen, A.D.C., Arits, A.H.M.M., Roemen, G.M.J.M., Speel, E.J.M., Steijlen, P.M., Geel, M., Mosterd, K.

“…Summary Basal cell naevus syndrome (BCNS) is an autosomal dominant disorder most commonly caused by a germline mutation in the Drosophila homologue of…”
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The unknown biology of the unknown primary tumour: a literature review by van de Wouw, A. J., Jansen, R. L. H., Speel, E. J. M., Hillen, H. F. P.

“…The unknown primary tumour (UPT) is an intriguing clinical phenomenon found in approximately 5% of all newly diagnosed patients with cancer. It is unclear…”
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Molecular alterations during insulinoma tumorigenesis by Jonkers, Y.M.H., Ramaekers, F.C.S., Speel, E.J.M.

“…Insulinomas are the most common functioning endocrine pancreatic tumors (EPTs). They present with clinical symptoms as a consequence of hypoglycemia induced by…”
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O200. Prognostic value of HPV and cervical metastasis in oropharyngeal squamous cell carcinomas by Straetmans, J.M.J.A.A., Olthof, N., Vos, I., Speel, E.J.M., Jong, J., Kremer, B.

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Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption by Farshadpour, F., Konings, S., Speel, E. J. M, Hordijk, G. J., Koole, R., van Blokland, M., Slootweg, P. J., Kummer, J. A.

“…We aimed to determine the role of HPV in the pathogenesis and outcome of oropharyngeal squamous cell carcinoma (OSCC) in lifelong nonsmoking and nondrinking…”
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Nuclear import as a barrier to infection of human umbilical vein endothelial cells by human cytomegalovirus strain AD169 by Slobbe-van Drunen, M.E.P, Hendrickx, A.T.M, Vossen, R.C.R.M, Speel, E.J.M, van Dam-Mieras, M.C.E, Bruggeman, C.A

“…Human embryonal fibroblasts (HEF) are fully permissive for infection by human cytomegalovirus (HCMV) strain AD169, whereas human umbilical vein endothelial…”
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Multi-PRINS : multiple sequential oligonucleotide primed in situ DNA synthesis reactions label specific chromosomes and produce bands by SPEEL, E. J. M, LAWSON, D, HOPMAN, A. H. N, GOSDEN, J

“…A fast method for identifying several chromosomes with chromosome-specific oligonucleotide primers directing an in situ labeling reaction is described. Up to…”
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