Search Results - "Speedy, E"

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci by Jäger, Roland, Migliorini, Gabriele, Henrion, Marc, Kandaswamy, Radhika, Speedy, Helen E., Heindl, Andreas, Whiffin, Nicola, Carnicer, Maria J., Broome, Laura, Dryden, Nicola, Nagano, Takashi, Schoenfelder, Stefan, Enge, Martin, Yuan, Yinyin, Taipale, Jussi, Fraser, Peter, Fletcher, Olivia, Houlston, Richard S.

“…Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping…”
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A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia by Speedy, Helen E, Di Bernardo, Maria Chiara, Sava, Georgina P, Dyer, Martin J S, Holroyd, Amy, Wang, Yufei, Sunter, Nicola J, Mansouri, Larry, Juliusson, Gunnar, Smedby, Karin E, Roos, Göran, Jayne, Sandrine, Majid, Aneela, Dearden, Claire, Hall, Andrew G, Mainou-Fowler, Tryfonia, Jackson, Graham H, Summerfield, Geoffrey, Harris, Robert J, Pettitt, Andrew R, Allsup, David J, Bailey, James R, Pratt, Guy, Pepper, Chris, Fegan, Chris, Rosenquist, Richard, Catovsky, Daniel, Allan, James M, Houlston, Richard S

“…Richard Houlston and colleagues report results of a genome-wide association study of chronic lymphocytic leukemia. They validate several new susceptibility…”
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Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism by Kandaswamy, Radhika, Sava, Georgina P., Speedy, Helen E., Beà, Sílvia, Martín-Subero, José I., Studd, James B., Migliorini, Gabriele, Law, Philip J., Puente, Xose S., Martín-García, David, Salaverria, Itziar, Gutiérrez-Abril, Jesús, López-Otín, Carlos, Catovsky, Daniel, Allan, James M., Campo, Elías, Houlston, Richard S.

“…Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We…”
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Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics by Speedy, Helen E., Beekman, Renée, Chapaprieta, Vicente, Orlando, Giulia, Law, Philip J., Martín-García, David, Gutiérrez-Abril, Jesús, Catovsky, Daniel, Beà, Sílvia, Clot, Guillem, Puiggròs, Montserrat, Torrents, David, Puente, Xose S., Allan, James M., López-Otín, Carlos, Campo, Elias, Houlston, Richard S., Martín-Subero, José I.

“…Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the…”
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Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk by Calandra, Sebastiano, Tarugi, Patrizia, Speedy, Helen E., Dean, Andrew F., Bertolini, Stefano, Shoulders, Carol C.

“…This review integrates historical biochemical and modern genetic findings that underpin our understanding of the low-density lipoprotein (LDL) dyslipidemias…”
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Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition by Aikio, Mari, Elamaa, Harri, Vicente, David, Izzi, Valerio, Kaur, Inderjeet, Seppinen, Lotta, Speedy, Helen E, Kaminska, Dorota, Kuusisto, Sanna, Sormunen, Raija, Heljasvaara, Ritva, Jones, Emma L, Muilu, Mikko, Jauhiainen, Matti, Pihlajamäki, Jussi, Savolainen, Markku J, Shoulders, Carol C, Pihlajaniemi, Taina

“…Collagen XVIII is an evolutionary conserved ubiquitously expressed basement membrane proteoglycan produced in three isoforms via two promoters (P). Here, we…”
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How Reliable Is a Statewide Prescription Monitoring Program for Identifying Post-Cesarean Opioid Use? by Premkumar, Ashish, Speedy, Sedona E, Miller, Emily S

“…This study was aimed to estimate the percentage of women taking opioids post-cesarean who could be detected in a state prescription monitoring program (PMP)…”
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CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients[S] by Horswell, Stuart D., Fryer, Lee G.D., Hutchison, Claire E., Zindrou, Dlear, Speedy, Helen E., Town, Margaret-M., Duncan, Emma J., Sivapackianathan, Rasheeta, Patel, Hetal N., Jones, Emma L., Braithwaite, Adam, Salm, Max P.A., Neuwirth, Claire K.Y., Potter, Elizabeth, Anderson, Jonathan R., Taylor, Kenneth M., Seed, Mary, Betteridge, D. John, Crook, Martin A., Wierzbicki, Anthony S., Scott, James, Naoumova, Rossi P., Shoulders, Carol C.

“…The purpose of this study was to determine the core biological processes perturbed in the subcutaneous adipose tissue of familial combined hyperlipidemia…”
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COSMIC: the Catalogue Of Somatic Mutations In Cancer by Tate, John G, Bamford, Sally, Jubb, Harry C, Sondka, Zbyslaw, Beare, David M, Bindal, Nidhi, Boutselakis, Harry, Cole, Charlotte G, Creatore, Celestino, Dawson, Elisabeth, Fish, Peter, Harsha, Bhavana, Hathaway, Charlie, Jupe, Steve C, Kok, Chai Yin, Noble, Kate, Ponting, Laura, Ramshaw, Christopher C, Rye, Claire E, Speedy, Helen E, Stefancsik, Ray, Thompson, Sam L, Wang, Shicai, Ward, Sari, Campbell, Peter J, Forbes, Simon A

“…Abstract COSMIC, the Catalogue Of Somatic Mutations In Cancer (https://cancer.sanger.ac.uk) is the most detailed and comprehensive resource for exploring the…”
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Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk by Sava, G P, Speedy, H E, Di Bernardo, M C, Dyer, M J S, Holroyd, A, Sunter, N J, Marr, H, Mansouri, L, Deaglio, S, Karabon, L, Frydecka, I, Jamroziak, K, Woszczyk, D, Juliusson, G, Smedby, K E, Jayne, S, Majid, A, Wang, Y, Dearden, C, Hall, A G, Mainou-Fowler, T, Jackson, G H, Summerfield, G, Harris, R J, Pettitt, A R, Allsup, D J, Bailey, J R, Pratt, G, Pepper, C, Fegan, C, Rosenquist, R, Catovsky, D, Allan, J M, Houlston, R S

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The promised land of individualized ovarian stimulation: Are we there yet? by Kim, Helen H., Speedy, Sedona E.

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National evaluation of multidisciplinary quality metrics for head and neck cancer by Cramer, John D., Speedy, Sedona E., Ferris, Robert L., Rademaker, Alfred W., Patel, Urjeet A., Samant, Sandeep

“…BACKGROUND The National Quality Forum has endorsed quality‐improvement measures for multiple cancer types that are being developed into actionable tools to…”
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Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia by Speedy, Helen E., Kinnersley, Ben, Chubb, Daniel, Broderick, Peter, Law, Philip J., Litchfield, Kevin, Jayne, Sandrine, Dyer, Martin J.S., Dearden, Claire, Follows, George A., Catovsky, Daniel, Houlston, Richard S.

“…Chronic lymphocytic leukemia (CLL) can be familial; however, thus far no rare germ line disruptive alleles for CLL have been identified. We performed…”
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Quality Improvement Initiative for Aspirin Screening and Prescription Rates for Preeclampsia Prevention in an Outpatient Obstetric Clinic by Kumar, Natasha R, Speedy, Sedona E, Song, Jing, Welty, Leah J, Cavens, Arjeme D

“…Hypertensive disorders of pregnancy (HDP) impact 10% of pregnancies in the United States and cause adverse maternal and neonatal outcomes such as prematurity…”
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rs2072135, a low‐penetrance variant for chronic lymphocytic leukaemia? by Sava, Georgina P., Speedy, Helen E., Bernardo, Maria Chiara, Deaglio, Silvia, Karabon, Lidia, Frydecka, Irena, Woszczyk, Dariusz, Rossi, Davide, Gaidano, Gianluca, Mansouri, Larry, Smedby, Karin E., Juliusson, Gunnar, Rosenquist, Richard, Catovsky, Daniel, Houlston, Richard S.

“…Summary Recent multi‐stage genome‐wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) that are robustly associated with…”
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The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism by Salm, Maximilian P A, Horswell, Stuart D, Hutchison, Claire E, Speedy, Helen E, Yang, Xia, Liang, Liming, Schadt, Eric E, Cookson, William O, Wierzbicki, Anthony S, Naoumova, Rossi P, Shoulders, Carol C

“…Genomic inversions are an increasingly recognized source of genetic variation. However, a lack of reliable high-throughput genotyping assays for these…”
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Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci by Law, Philip J., Sud, Amit, Mitchell, Jonathan S., Henrion, Marc, Orlando, Giulia, Lenive, Oleg, Broderick, Peter, Speedy, Helen E., Johnson, David C., Kaiser, Martin, Weinhold, Niels, Cooke, Rosie, Sunter, Nicola J., Jackson, Graham H., Summerfield, Geoffrey, Harris, Robert J., Pettitt, Andrew R., Allsup, David J., Carmichael, Jonathan, Bailey, James R., Pratt, Guy, Rahman, Thahira, Pepper, Chris, Fegan, Chris, von Strandmann, Elke Pogge, Engert, Andreas, Försti, Asta, Chen, Bowang, Filho, Miguel Inacio da Silva, Thomsen, Hauke, Hoffmann, Per, Noethen, Markus M., Eisele, Lewin, Jöckel, Karl-Heinz, Allan, James M., Swerdlow, Anthony J., Goldschmidt, Hartmut, Catovsky, Daniel, Morgan, Gareth J., Hemminki, Kari, Houlston, Richard S.

“…B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic…”
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Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis by Sava, Georgina P., Speedy, Helen E., Houlston, Richard S.

“…Abstract To evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to chronic lymphocytic leukemia (CLL), we…”
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Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia by Law, Philip J., Berndt, Sonja I., Speedy, Helen E., Camp, Nicola J., Sava, Georgina P., Skibola, Christine F., Holroyd, Amy, Joseph, Vijai, Sunter, Nicola J., Nieters, Alexandra, Bea, Silvia, Monnereau, Alain, Martin-Garcia, David, Goldin, Lynn R., Clot, Guillem, Teras, Lauren R., Quintela, Inés, Birmann, Brenda M., Jayne, Sandrine, Cozen, Wendy, Majid, Aneela, Smedby, Karin E., Lan, Qing, Dearden, Claire, Brooks-Wilson, Angela R., Hall, Andrew G., Purdue, Mark P., Mainou-Fowler, Tryfonia, Vajdic, Claire M., Jackson, Graham H., Cocco, Pierluigi, Marr, Helen, Zhang, Yawei, Zheng, Tongzhang, Giles, Graham G., Lawrence, Charles, Call, Timothy G., Liebow, Mark, Melbye, Mads, Glimelius, Bengt, Mansouri, Larry, Glenn, Martha, Curtin, Karen, Diver, W Ryan, Link, Brian K., Conde, Lucia, Bracci, Paige M., Holly, Elizabeth A., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, McKay, James, Albanes, Demetrius, Weinstein, Stephanie, Wang, Zhaoming, Caporaso, Neil E., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Vermeulen, Roel C. H., Southey, Melissa C., Milne, Roger L., Clavel, Jacqueline, Topka, Sabine, Spinelli, John J., Kraft, Peter, Ennas, Maria Grazia, Summerfield, Geoffrey, Ferri, Giovanni M., Harris, Robert J., Miligi, Lucia, Pettitt, Andrew R., North, Kari E., Allsup, David J., Fraumeni, Joseph F., Bailey, James R., Offit, Kenneth, Pratt, Guy, Hjalgrim, Henrik, Pepper, Chris, Chanock, Stephen J., Fegan, Chris, Rosenquist, Richard, de Sanjose, Silvia, Carracedo, Angel, Dyer, Martin J. S., Catovsky, Daniel, Campo, Elias, Cerhan, James R., Allan, James M., Rothman, Nathanial, Houlston, Richard, Slager, Susan

“…Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a…”
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Inherited susceptibility to CLL by Speedy, Helen E, Sava, Georgina, Houlston, Richard S

“…Chronic lymphocytic leukaemia (CLL) is the most common lymphoid malignancy in Western countries, accounting for around a quarter of all leukaemias. Despite a…”
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