Search Results - "Speed, Doug"

SumHer better estimates the SNP heritability of complex traits from summary statistics by Speed, Doug, Balding, David J.

“…We present SumHer, software for estimating confounding bias, SNP heritability, enrichments of heritability and genetic correlations using summary statistics…”
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MultiBLUP: improved SNP-based prediction for complex traits by Speed, Doug, Balding, David J

“…BLUP (best linear unbiased prediction) is widely used to predict complex traits in plant and animal breeding, and increasingly in human genetics. The BLUP…”
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Improved genetic prediction of complex traits from individual-level data or summary statistics by Zhang, Qianqian, Privé, Florian, Vilhjálmsson, Bjarni, Speed, Doug

“…Most existing tools for constructing genetic prediction models begin with the assumption that all genetic variants contribute equally towards the phenotype…”
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Reevaluation of SNP heritability in complex human traits by Speed, Doug, Cai, Na, Johnson, Michael R, Nejentsev, Sergey, Balding, David J

“…By analyzing imputed genetic data for 42 human traits, Doug Speed and colleagues derive a model that describes how heritability varies with minor allele…”
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Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast by Jeffares, Daniel C., Jolly, Clemency, Hoti, Mimoza, Speed, Doug, Shaw, Liam, Rallis, Charalampos, Balloux, Francois, Dessimoz, Christophe, Bähler, Jürg, Sedlazeck, Fritz J.

“…Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic…”
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Investigating the association between body fat and depression via Mendelian randomization by Speed, Maria S., Jefsen, Oskar H., Børglum, Anders D., Speed, Doug, Østergaard, Søren D.

“…Obesity and depression are major public health concerns that are both associated with substantial morbidity and mortality. There is a considerable body of…”
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Describing the genetic architecture of epilepsy through heritability analysis by SPEED, Doug, O'BRIEN, Terence J, PALOTIE, Aarno, SHKURA, Kirill, MARSON, Anthony G, BALDING, David J, JOHNSON, Michael R

“…Epilepsy is a disease with substantial missing heritability; despite its high genetic component, genetic association studies have had limited success detecting…”
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Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis by Grace, Cooper Alastair, Sousa Carvalho, Kátia Silene, Sousa Lima, Mayara Ingrid, Costa Silva, Vladimir, Reis-Cunha, João Luís, Brune, Matthew J, Forrester, Sarah, Pedrozo E Silva de Azevedo, Conceição de Maria, Costa, Dorcas Lamounier, Speed, Doug, Mottram, Jeremy C, Jeffares, Daniel C, Costa, Carlos H N

“…Visceral leishmaniasis (VL) is a potentially fatal disease caused mainly by Leishmania infantum in South America and Leishmania donovani in Asia and Africa…”
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Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice by Krohn, Jon, Speed, Doug, Palme, Rupert, Touma, Chadi, Mott, Richard, Flint, Jonathan

“…The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse…”
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Signatures of TSPAN8 variants associated with human metabolic regulation and diseases by De, Tisham, Goncalves, Angela, Speed, Doug, Froguel, Philippe, Gaffney, Daniel J., Johnson, Michael R., Jarvelin, Marjo-Riitta, Coin, Lachlan JM

“…Here, with the example of common copy number variation (CNV) in the TSPAN8 gene, we present an important piece of work in the field of CNV detection, that is,…”
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Evaluating and improving heritability models using summary statistics by Speed, Doug, Holmes, John, Balding, David J.

“…There is currently much debate regarding the best model for how heritability varies across the genome. The authors of GCTA recommend the GCTA-LDMS-I model, the…”
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Relatedness in the post-genomic era: is it still useful? by Speed, Doug, Balding, David J.

“…Key Points Relatedness is a fundamental concept in everyday life and in quantitative genetics. It has a central role in efforts to understand genetic…”
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Using polygenic risk scores to investigate the evolution of smoking and mental health outcomes in UK biobank participants by Balbuena, Lloyd, Peters, Evyn, Speed, Doug

“…Abstract Objective Mendelian randomization studies report a bi‐directional relation between cigarette smoking and mental disorders, yet from a clinical…”
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The heritability of fitness in a wild annual plant population with hierarchical size structure by Schoen, Daniel J, Speed, Doug

“…The relative magnitude of additive genetic vs. residual variation for fitness traits is important in models for predicting the rate of evolution and population…”
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SNP‐based heritability and selection analyses: Improved models and new results by Speed, Doug, Kaphle, Anubhav, Balding, David J.

“…Complex‐trait genetics has advanced dramatically through methods to estimate the heritability tagged by SNPs, both genome‐wide and in genomic regions of…”
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Estimating disease heritability from complex pedigrees allowing for ascertainment and covariates by Speed, Doug, Evans, David M.

“…We propose TetraHer, a method for estimating the liability heritability of binary phenotypes. TetraHer has five key features. First, it can be applied to data…”
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LDAK-GBAT: Fast and powerful gene-based association testing using summary statistics by Berrandou, Takiy-Eddine, Balding, David, Speed, Doug

“…We present LDAK-GBAT, a tool for gene-based association testing using summary statistics from genome-wide association studies that is computationally…”
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Improved Heritability Estimation from Genome-wide SNPs by Speed, Doug, Hemani, Gibran, Johnson, Michael R., Balding, David J.

“…Estimation of narrow-sense heritability, h2, from genome-wide SNPs genotyped in unrelated individuals has recently attracted interest and offers several…”
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Graph pangenome captures missing heritability and empowers tomato breeding by Zhou, Yao, Zhang, Zhiyang, Bao, Zhigui, Li, Hongbo, Lyu, Yaqing, Zan, Yanjun, Wu, Yaoyao, Cheng, Lin, Fang, Yuhan, Wu, Kun, Zhang, Jinzhe, Lyu, Hongjun, Lin, Tao, Gao, Qiang, Saha, Surya, Mueller, Lukas, Fei, Zhangjun, Städler, Thomas, Xu, Shizhong, Zhang, Zhiwu, Speed, Doug, Huang, Sanwen

“…Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits 1 , 2 . The solution to this…”
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Participation bias in the UK Biobank distorts genetic associations and downstream analyses by Schoeler, Tabea, Speed, Doug, Porcu, Eleonora, Pirastu, Nicola, Pingault, Jean-Baptiste, Kutalik, Zoltán

“…While volunteer-based studies such as the UK Biobank have become the cornerstone of genetic epidemiology, the participating individuals are rarely…”
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