Search Results - "Spector, D."

Role of the gut microbiota in nutrition and health by Valdes, Ana M, Walter, Jens, Segal, Eran, Spector, Tim D

“…Ana M Valdes and colleagues discuss strategies for modulating the gut microbiota through diet and probiotics…”
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Genetic Determinants of the Gut Microbiome in UK Twins by Goodrich, Julia K., Davenport, Emily R., Beaumont, Michelle, Jackson, Matthew A., Knight, Rob, Ober, Carole, Spector, Tim D., Bell, Jordana T., Clark, Andrew G., Ley, Ruth E.

“…Studies in mice and humans have revealed intriguing associations between host genetics and the microbiome. Here we report a 16S rRNA-based analysis of the gut…”
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Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration by Leeming, Emily R, Johnson, Abigail J, Spector, Tim D, Le Roy, Caroline I

“…The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem implicated in health and disease. The composition of the gut microbiota…”
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Gut microbiota associations with common diseases and prescription medications in a population-based cohort by Jackson, Matthew A., Verdi, Serena, Maxan, Maria-Emanuela, Shin, Cheol Min, Zierer, Jonas, Bowyer, Ruth C. E., Martin, Tiphaine, Williams, Frances M. K., Menni, Cristina, Bell, Jordana T., Spector, Tim D., Steves, Claire J.

“…The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut…”
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Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study by Menni, Cristina, Klaser, Kerstin, May, Anna, Polidori, Lorenzo, Capdevila, Joan, Louca, Panayiotis, Sudre, Carole H, Nguyen, Long H, Drew, David A, Merino, Jordi, Hu, Christina, Selvachandran, Somesh, Antonelli, Michela, Murray, Benjamin, Canas, Liane S, Molteni, Erika, Graham, Mark S, Modat, Marc, Joshi, Amit D, Mangino, Massimo, Hammers, Alexander, Goodman, Anna L, Chan, Andrew T, Wolf, Jonathan, Steves, Claire J, Valdes, Ana M, Ourselin, Sebastien, Spector, Tim D

“…The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We…”
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Interplay between the human gut microbiome and host metabolism by Visconti, Alessia, Le Roy, Caroline I., Rosa, Fabio, Rossi, Niccolò, Martin, Tiphaine C., Mohney, Robert P., Li, Weizhong, de Rinaldis, Emanuele, Bell, Jordana T., Venter, J. Craig, Nelson, Karen E., Spector, Tim D., Falchi, Mario

“…The human gut is inhabited by a complex and metabolically active microbial ecosystem. While many studies focused on the effect of individual microbial taxa on…”
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The fecal metabolome as a functional readout of the gut microbiome by Zierer, Jonas, Jackson, Matthew A., Kastenmüller, Gabi, Mangino, Massimo, Long, Tao, Telenti, Amalio, Mohney, Robert P., Small, Kerrin S., Bell, Jordana T., Steves, Claire J., Valdes, Ana M., Spector, Tim D., Menni, Cristina

“…The human gut microbiome plays a key role in human health 1 , but 16S characterization lacks quantitative functional annotation 2 . The fecal metabolome…”
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Real-time tracking of self-reported symptoms to predict potential COVID-19 by Menni, Cristina, Valdes, Ana M., Freidin, Maxim B., Sudre, Carole H., Nguyen, Long H., Drew, David A., Ganesh, Sajaysurya, Varsavsky, Thomas, Cardoso, M. Jorge, El-Sayed Moustafa, Julia S., Visconti, Alessia, Hysi, Pirro, Bowyer, Ruth C. E., Mangino, Massimo, Falchi, Mario, Wolf, Jonathan, Ourselin, Sebastien, Chan, Andrew T., Steves, Claire J., Spector, Tim D.

“…A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2…”
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Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study by Antonelli, Michela, Penfold, Rose S, Merino, Jordi, Sudre, Carole H, Molteni, Erika, Berry, Sarah, Canas, Liane S, Graham, Mark S, Klaser, Kerstin, Modat, Marc, Murray, Benjamin, Kerfoot, Eric, Chen, Liyuan, Deng, Jie, Österdahl, Marc F, Cheetham, Nathan J, Drew, David A, Nguyen, Long H, Pujol, Joan Capdevila, Hu, Christina, Selvachandran, Somesh, Polidori, Lorenzo, May, Anna, Wolf, Jonathan, Chan, Andrew T, Hammers, Alexander, Duncan, Emma L, Spector, Tim D, Ourselin, Sebastien, Steves, Claire J

“…COVID-19 vaccines show excellent efficacy in clinical trials and effectiveness in real-world data, but some people still become infected with SARS-CoV-2 after…”
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The UK Adult Twin Registry (TwinsUK Resource) by Moayyeri, Alireza, Hammond, Christopher J., Hart, Deborah J., Spector, Timothy D.

“…TwinsUK is a nation-wide registry of volunteer twins in the United Kingdom, with about 12,000 registered twins (83% female, equal number of monozygotic and…”
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Host genetic variation impacts microbiome composition across human body sites by Blekhman, Ran, Goodrich, Julia K, Huang, Katherine, Sun, Qi, Bukowski, Robert, Bell, Jordana T, Spector, Timothy D, Keinan, Alon, Ley, Ruth E, Gevers, Dirk, Clark, Andrew G

“…The composition of bacteria in and on the human body varies widely across human individuals, and has been associated with multiple health conditions. While…”
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Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study by Stegemann, Christin, Pechlaner, Raimund, Willeit, Peter, Langley, Sarah R, Mangino, Massimo, Mayr, Ursula, Menni, Cristina, Moayyeri, Alireza, Santer, Peter, Rungger, Gregor, Spector, Tim D, Willeit, Johann, Kiechl, Stefan, Mayr, Manuel

“…BACKGROUND—The bulk of cardiovascular disease risk is not explained by traditional risk factors. Recent advances in mass spectrometry allow the identification…”
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Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study by Costeira, Ricardo, Lee, Karla A, Murray, Benjamin, Christiansen, Colette, Castillo-Fernandez, Juan, Ni Lochlainn, Mary, Capdevila Pujol, Joan, Macfarlane, Heather, Kenny, Louise C, Buchan, Iain, Wolf, Jonathan, Rymer, Janice, Ourselin, Sebastien, Steves, Claire J, Spector, Timothy D, Newson, Louise R, Bell, Jordana T

“…It has been widely observed that adult men of all ages are at higher risk of developing serious complications from COVID-19 when compared with women. This…”
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Proton pump inhibitors alter the composition of the gut microbiota by Jackson, Matthew A, Goodrich, Julia K, Maxan, Maria-Emanuela, Freedberg, Daniel E, Abrams, Julian A, Poole, Angela C, Sutter, Jessica L, Welter, Daphne, Ley, Ruth E, Bell, Jordana T, Spector, Tim D, Steves, Claire J

“…Proton pump inhibitors (PPIs) are drugs used to suppress gastric acid production and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux…”
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The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis by Roederer, Mario, Quaye, Lydia, Mangino, Massimo, Beddall, Margaret H., Mahnke, Yolanda, Chattopadhyay, Pratip, Tosi, Isabella, Napolitano, Luca, Terranova Barberio, Manuela, Menni, Cristina, Villanova, Federica, Di Meglio, Paola, Spector, Tim D., Nestle, Frank O.

“…Despite recent discoveries of genetic variants associated with autoimmunity and infection, genetic control of the human immune system during homeostasis is…”
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Changes in Medical Errors after Implementation of a Handoff Program by Starmer, Amy J, Spector, Nancy D, Srivastava, Rajendu, West, Daniel C, Rosenbluth, Glenn, Allen, April D, Noble, Elizabeth L, Tse, Lisa L, Dalal, Anuj K, Keohane, Carol A, Lipsitz, Stuart R, Rothschild, Jeffrey M, Wien, Matthew F, Yoon, Catherine S, Zigmont, Katherine R, Wilson, Karen M, O’Toole, Jennifer K, Solan, Lauren G, Aylor, Megan, Bismilla, Zia, Coffey, Maitreya, Mahant, Sanjay, Blankenburg, Rebecca L, Destino, Lauren A, Everhart, Jennifer L, Patel, Shilpa J, Bale, James F, Spackman, Jaime B, Stevenson, Adam T, Calaman, Sharon, Cole, F. Sessions, Balmer, Dorene F, Hepps, Jennifer H, Lopreiato, Joseph O, Yu, Clifton E, Sectish, Theodore C, Landrigan, Christopher P

“…The authors developed an intervention to improve the quality of the handoff of hospitalized patients; it was associated with reductions in medical errors and…”
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The gut microbiome: what the oncologist ought to know by Lee, K. A., Luong, M. K., Shaw, H., Nathan, P., Bataille, V., Spector, T. D.

“…The gut microbiome (GM) has been implicated in a vast number of human pathologies and has become a focus of oncology research over the past 5 years. The normal…”
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Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease by Kaye, David M., Shihata, Waled A., Jama, Hamdi A., Tsyganov, Kirill, Ziemann, Mark, Kiriazis, Helen, Horlock, Duncan, Vijay, Amrita, Giam, Beverly, Vinh, Antony, Johnson, Chad, Fiedler, April, Donner, Daniel, Snelson, Matthew, Coughlan, Melinda T., Phillips, Sarah, Du, Xiao-Jun, El-Osta, Assam, Drummond, Grant, Lambert, Gavin W., Spector, Tim D., Valdes, Ana M., Mackay, Charles R., Marques, Francine Z.

“…BACKGROUND:High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle…”
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Role of the gut microbiome for cancer patients receiving immunotherapy: Dietary and treatment implications by Lee, Karla A., Shaw, Heather M., Bataille, Veronique, Nathan, Paul, Spector, Tim D.

“…Immune-checkpoint inhibitors (ICIs) have revolutionised the therapeutic landscape for multiple malignancies and the health of the gut microbiome (GM) is…”
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Obesity accelerates epigenetic aging of human liver by Horvath, Steve, Erhart, Wiebke, Brosch, Mario, Ammerpohl, Ole, von Schönfels, Witigo, Ahrens, Markus, Heits, Nils, Bell, Jordana T., Tsai, Pei-Chien, Spector, Tim D., Deloukas, Panos, Siebert, Reiner, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Schafmayer, Clemens, Hampe, Jochen

“…Significance Because obese people are at an increased risk of many age-related diseases, it is a plausible hypothesis that obesity increases the biological age…”
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