Search Results - "Specks, U."

2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides by Jennette, J. C., Falk, R. J., Bacon, P. A., Basu, N., Cid, M. C., Ferrario, F., Flores‐Suarez, L. F., Gross, W. L., Guillevin, L., Hagen, E. C., Hoffman, G. S., Jayne, D. R., Kallenberg, C. G. M., Lamprecht, P., Langford, C. A., Luqmani, R. A., Mahr, A. D., Matteson, E. L., Merkel, P. A., Ozen, S., Pusey, C. D., Rasmussen, N., Rees, A. J., Scott, D. G. I., Specks, U., Stone, J. H., Takahashi, K., Watts, R. A.

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Rituximab treatment of idiopathic membranous nephropathy by Fervenza, F.C., Cosio, F.G., Erickson, S.B., Specks, U., Herzenberg, A.M., Dillon, J.J., Leung, N., Cohen, I.M., Wochos, D.N., Bergstralh, E., Hladunewich, M., Cattran, D.C.

“…Idiopathic membranous nephropathy is a common cause of nephrotic syndrome whose pathogenesis may involve B-cell functions. Rituximab is a monoclonal antibody…”
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Cocaine-induced midline destructive lesions — An autoimmune disease? by Trimarchi, M, Bussi, M, Sinico, R.A, Meroni, Pierluigi, Specks, U

“…Abstract In Europe it is estimated that around 13 million of adults (15–64 years) have used cocaine at least once in their lifetime. The most frequently used…”
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Clinical Outcomes of Remission Induction Therapy for Severe Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Miloslavsky, E. M., Specks, U., Merkel, P. A., Seo, P., Spiera, R., Langford, C. A., Hoffman, G. S., Kallenberg, C. G. M., St.Clair, E. W., Tchao, N. K., Viviano, L., Ding, L., Sejismundo, L. P., Mieras, K., Iklé, D., Jepson, B., Mueller, M., Brunetta, P., Allen, N. B., Fervenza, F. C., Geetha, D., Keogh, K., Kissin, E. Y., Monach, P. A., Peikert, T., Stegeman, C., Ytterberg, S. R., Stone, J. H.

“…Objective To evaluate the reasons that complete remission is not achieved or maintained with original treatment in some patients with antineutrophil…”
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Recurrence of ANCA-associated vasculitis following renal transplantation in the modern era of immunosupression by Gera, M., Griffin, M.-D., Specks, U., Leung, N., Stegall, M.-D., Fervenza, F.-C.

“…Progressive glomerulonephritis and attendant end-stage renal disease (ESRD) result from antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The…”
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Rituximab for the Treatment of Relapses in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Miloslavsky, E. M., Specks, U., Merkel, P. A., Seo, P., Spiera, R., Langford, C. A., Hoffman, G. S., Kallenberg, C. G. M., St.Clair, E. W., Tchao, N. K., Viviano, L., Ding, L., Iklé, D., Villarreal, M., Jepson, B., Brunetta, P., Allen, N. B., Fervenza, F. C., Geetha, D., Keogh, K., Kissin, E. Y., Monach, P. A., Peikert, T., Stegeman, C., Ytterberg, S. R., Stone, J. H.

“…Objective Disease relapses are frequent in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). This study was undertaken to evaluate outcomes in…”
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Outcomes of Nonsevere Relapses in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Treated With Glucocorticoids by Miloslavsky, E. M., Specks, U., Merkel, P. A., Seo, P., Spiera, R., Langford, C. A., Hoffman, G. S., Kallenberg, C. G. M., St.Clair, E. W., Tchao, N. K., Ding, L., Iklé, D., Villareal, M., Lim, N., Brunetta, P., Fervenza, F. C., Monach, P. A., Stone, J. H.

“…Objective Nonsevere relapses are more common than severe relapses in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), but their clinical…”
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Etanercept for the treatment of stage II and III progressive pulmonary sarcoidosis by Utz, James P, Limper, Andrew H, Kalra, Sanjay, Specks, Ulrich, Scott, John P, Vuk-Pavlovic, Zvezdana, Schroeder, Darrell R

“…Tumor necrosis factor (TNF)-alpha is produced by macrophages and other cells, and is believed to participate in granulomatous inflammation. Targeted antagonism…”
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Comparison of disease activity measures for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis by Merkel, P A, Cuthbertson, D D, Hellmich, B, Hoffman, G S, Jayne, D R W, Kallenberg, C G M, Krischer, J P, Luqmani, R, Mahr, A D, Matteson, E L, Specks, U, Stone, J H

“…Currently, several different instruments are used to measure disease activity and extent in clinical trials of anti-neutrophil cytoplasmic autoantibody…”
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Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis by Clain, J. M., Hummel, A. M., Stone, J. H., Fervenza, F. C., Hoffman, G. S., Kallenberg, C. G. M., Langford, C. A., McCune, W. J., Merkel, P. A., Monach, P. A., Seo, P., Spiera, R. F., St Clair, E. W., Ytterberg, S. R., Specks, U.

“…Summary Anti‐neutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA‐associated vasculitis (AAV). However, ANCA…”
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Corrigendum to “Cocaine-induced midline destructive lesions — an autoimmune disease?” [Autoimmun. Rev. 12 (2013) 496–500] by Trimarchi, M, Bussi, M, Sinico, R.A, Meroni, P.L, Specks, U

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Corrigendum to “Otorhinolaryngological manifestations in granulomatosis with polyangiitis (Wegener's)” [Autoimmun. Rev. 12 (2013) 501–505] by Trimarchi, M, Sinico, R.A, Teggi, R, Bussi, M, Specks, U, Meroni, P.L

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Successful Induction of Remission With Rituximab for Relapse of ANCA‐Associated Vasculitis Post‐Kidney Transplant: Report of Two Cases by Geetha, D., Seo, P., Specks, U., Fervenza, F. C.

“…Kidney transplantation should be considered the treatment of choice for patients with end‐stage renal disease due to antineutrophil cytoplasmic antibody (ANCA)…”
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Interaction of proteinase 3 with CD11b/CD18 (β2integrin) on the cell membrane of human neutrophils by David, A., Kacher, Y., Specks, U., Aviram, I.

“…Proteinase 3 (PR3), the target autoantigen of antineutrophil cytoplasmic antibodies in the autoimmune vasculitis, Wegener’s granulomatosis, is a serine…”
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Lung toxicity associated with cyclophosphamide use. Two distinct patterns by Malik, S W, Myers, J L, DeRemee, R A, Specks, U

“…Cyclophosphamide-induced lung toxicity may be difficult to recognize because of the presence of confounding variables such as concomitant use of other…”
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Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments by Wiesner, Olaf, Litwiller, Robert D., Hummel, Amber M., Viss, Margaret A., McDonald, Cari J., Jenne, Dieter E., Fass, David N., Specks, U.

“…Direct comparisons of human (h) and murine (m) neutrophil elastase (NE) and proteinase 3 (PR3) are important for the understanding and interpretation of…”
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Part 2: Synopsis of B-lymphocyte targeted therapy of ANCA-associated vasculitis by GOLBIN, J. M, SPECKS, U

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Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener granulomatosis by Nölle, B, Specks, U, Lüdemann, J, Rohrbach, M S, DeRemee, R A, Gross, W L

“…To determine disease specificity and sensitivity of anticytoplasmic autoantibodies (ACPA) for Wegener granulomatosis, as well as their value as a marker of…”
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Agreement of anti‐neutrophil cytoplasmic antibody measurements obtained from serum and plasma by Lee, A. S., Finkielman, J. D., Peikert, T., Hummel, A. M., Viss, M. A., Jacob, G. L., Homburger, H. A., Specks, U.

“…Summary Serum and plasma are used interchangeably to measure anti‐neutrophil cytoplasmic antibodies (ANCA), even though the release of ANCA target antigens…”
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Human mast cells expressing recombinant proteinase 3 (PR3) as substrate for clinical testing for anti‐neutrophil cytoplasmic antibodies (ANCA) by SPECKS, U., WIEGERT, E. M., HOMBURGER, H. A.

“…We have expressed conformationally intact, enzymatically active recombinant PR3 in HMC‐1 cells (HMC‐1/PR3 cells) that is recognized by C‐ANCA. Here we directly…”
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