Search Results - "Speck, Roberto F"

Broad-Range 16S rRNA Gene Polymerase Chain Reaction for Diagnosis of Culture-Negative Bacterial Infections by Rampini, Silvana K., Bloemberg, Guido V., Keller, Peter M., Büchler, Andrea C., Dollenmaier, Günter, Speck, Roberto F., Böttger, Erik C.

“…Background. Broad-range 16S ribosomal RNA (rRNA) gene polymerase chain reaction (PCR) is used for detection and identification of bacterial pathogens in…”
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Triggering TLR2, -3, -4, -5, and -8 reinforces the restrictive nature of M1- and M2-polarized macrophages to HIV by Schlaepfer, Erika, Rochat, Mary-Aude, Duo, Li, Speck, Roberto F

“…Macrophages must react to a large number of pathogens and their effects. In chronic HIV infection, the microenvironment changes with an influx of microbial…”
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Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1 by Nischang, Marc, Sutmuller, Roger, Gers-Huber, Gustavo, Audigé, Annette, Li, Duo, Rochat, Mary-Aude, Baenziger, Stefan, Hofer, Ursula, Schlaepfer, Erika, Regenass, Stephan, Amssoms, Katie, Stoops, Bart, Van Cauwenberge, Anja, Boden, Daniel, Kraus, Guenter, Speck, Roberto F

“…Humanized mice generate a lymphoid system of human origin subsequent to transplantation of human CD34+ cells and thus are highly susceptible to HIV infection…”
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The Humanized Mouse Model: What Added Value Does It Offer for HIV Research? by Baroncini, Luca, Bredl, Simon, Nicole, Kadzioch P, Speck, Roberto F

“…In the early 2000s, novel humanized mouse models based on the transplantation of human hematopoietic stem and progenitor cells (HSPCs) into immunocompromised…”
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Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2−/−γc−/− mice by Baenziger, Stefan, Tussiwand, Roxane, Schlaepfer, Erika, Mazzucchelli, Luca, Heikenwalder, Mathias, Kurrer, Michael O, Behnke, Silvia, Frey, Joachim, Oxenius, Annette, Joller, Helen, Aguzzi, Adriano, Manz, Markus G, Speck, Roberto F

“…Because of species selectivity, HIV research is largely restricted to in vitro or clinical studies, both limited in their ability to rapidly assess new…”
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Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology by Baenziger, Stefan, Heikenwalder, Mathias, Johansen, Pål, Schlaepfer, Erika, Hofer, Ursula, Miller, Regina C., Diemand, Simone, Honda, Kenya, Kundig, Thomas M., Aguzzi, Adriano, Speck, Roberto F.

“…Chronic immune activation is a major cause for progressive immunodeficiency in human immunodeficiency virus type-1 (HIV) infection. The underlying trigger,…”
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In utero Hepatitis B Immunization during Fetal Surgery for Spina Bifida by Moehrlen, Ueli, Elrod, Julia, Ochsenbein-Kölble, Nicole, Berger, Christoph, Speck, Roberto F, Mazzone, Luca, Krähenmann, Franziska, Zimmermann, Roland, Meuli, Martin

“…Fetal surgery for spina bifida aperta may lead to significantly better outcomes than postnatal repair, particularly regarding shunt-dependent hydrocephalus,…”
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RNA with chemotherapeutic base analogues as a dual-functional anti-cancer drug by Jarzebska, Natalia Teresa, Tusup, Marina, Frei, Julia, Weiss, Tobias, Holzinger, Tim, Mellett, Mark, Diken, Mustafa, Bredl, Simon, Weller, Michael, Speck, Roberto F., Kündig, Thomas M., Sahin, Ugur, Pascolo, Steve

“…Nanoparticles of different sizes formulated with unmodified RNA and Protamine differentially engage Toll-like Receptors (TLRs) and activate innate immune…”
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TLR7/8 Triggering Exerts Opposing Effects in Acute versus Latent HIV Infection by Schlaepfer, Erika, Audige, Annette, Joller, Helene, Speck, Roberto F

“…TLRs trigger innate immunity by recognizing conserved motifs of microorganisms. Recently, ssRNAs from HIV and influenza virus were shown to trigger TLR7 and 8…”
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Antigen kinetics determines immune reactivity by Johansen, Pål, Storni, Tazio, Rettig, Lorna, Qiu, Zhiyong, Der-Sarkissian, Ani, Smith, Kent A, Manolova, Vania, Lang, Karl S, Senti, Gabriela, Müllhaupt, Beat, Gerlach, Tilman, Speck, Roberto F, Bot, Adrian, Kündig, Thomas M

“…A current paradigm in immunology is that the strength of T cell responses is governed by antigen dose, localization, and costimulatory signals. This study…”
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Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells by Audigé, Annette, Rochat, Mary-Aude, Li, Duo, Ivic, Sandra, Fahrny, Audrey, Muller, Christina K S, Gers-Huber, Gustavo, Myburgh, Renier, Bredl, Simon, Schlaepfer, Erika, Scherrer, Alexandra U, Kuster, Stefan P, Speck, Roberto F

“…Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important…”
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Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART by Rochat, Mary-Aude, Schlaepfer, Erika, Kuster, Stefan P, Li, Duo, Audige, Annette, Ivic, Sandra, Fahrny, Audrey, Speck, Roberto F

“…The major obstacle to cure of HIV type-1 infection is the presence of the HIV reservoir, hidden from the immune system and insensitive to combined…”
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Anti-HIV activity mediated by natural killer and CD8+ cells after toll-like receptor 7/8 triggering by Schlaepfer, Erika, Speck, Roberto F

“…We previously found that triggering TLR7/8 either by single stranded HIV RNA or synthetic compounds induced changes in the lymphoid microenvironment…”
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Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown by Rousset, Francis, Salmon, Patrick, Bredl, Simon, Cherpin, Ophélie, Coelho, Marta, Myburgh, Renier, Alessandrini, Marco, Perny, Michael, Roccio, Marta, Speck, Roberto F., Senn, Pascal, Krause, Karl Heinz

“…Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We…”
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Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection by BOCHUD, Pierre-Yves, HERSBERGER, Martin, ADEREM, Alan, TAFFE, Patrick, BOCHUD, Murielle, STEIN, Catherine M, RODRIGUES, Stephanie D, CALANDRA, Thierry, FRANCIOLI, Patrick, TELENTI, Amalio, SPECK, Roberto F

“…The clinical course of HIV-1 infection is highly variable among individuals, at least in part as a result of genetic polymorphisms in the host. Toll-like…”
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Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals by Zhu, Yong, Gasbarri, Matteo, Zebret, Soumaila, Pawar, Sujeet, Mathez, Gregory, Diderich, Jacob, Valencia-Camargo, Alma Delia, Russenberger, Doris, Wang, Heyun, Silva, Paulo Henrique Jacob, Dela Cruz, Jay-ar B., Wei, Lixia, Cagno, Valeria, Münz, Christian, Speck, Roberto F., Desmecht, Daniel, Stellacci, Francesco

“…Most viruses start their invasion by binding to glycoproteins’ moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA])…”
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Inadequate clearance of translocated bacterial products in HIV-infected humanized mice by Hofer, Ursula, Schlaepfer, Erika, Baenziger, Stefan, Nischang, Marc, Regenass, Stephan, Schwendener, Reto, Kempf, Werner, Nadal, David, Speck, Roberto F

“…Bacterial translocation from the gut and subsequent immune activation are hallmarks of HIV infection and are thought to determine disease progression…”
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Efficient Human Cytomegalovirus Replication in Primary Endothelial Cells Is SOCS3 Dependent by Sonzogni, Olmo, Millard, Anne-Laure, Taveira, Aline, Schneider, Mårten K J, Duo, Li, Speck, Roberto F, Wulf, Gerburg M, Mueller, Nicolas J

“…In immunocompromised patients, human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality. Suppressor of cytokine signaling (SOCS)…”
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Ribavirin Concentrations Do Not Predict Sustained Virological Response in HIV/HCV-Coinfected Patients Treated with Ribavirin and Pegylated Interferon in the Swiss HIV Cohort Study by Kovari, Helen, Russmann, Stefan, Ledergerber, Bruno, Müller, Daniel, Rotger, Margalida, Velli, Pablo, Cavassini, Matthias, Ambrosioni, Juan, Bregenzer, Andrea, Stöckle, Marcel, Bernasconi, Enos, Rauch, Andri, Speck, Roberto F

“…Ribavirin (RBV) is an essential component of most current hepatitis C (HCV) treatment regimens and still standard of care in the combination with pegylated…”
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Telomerase activity impacts on Epstein-Barr virus infection of AGS cells by Rac, Jürgen, Haas, Florian, Schumacher, Andrina, Middeldorp, Jaap M, Delecluse, Henri-Jacques, Speck, Roberto F, Bernasconi, Michele, Nadal, David

“…The Epstein-Barr virus (EBV) is transmitted from host-to-host via saliva and is associated with epithelial malignancies including nasopharyngeal carcinoma…”
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