Search Results - "Spechler, Stuart Jon"

Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations by Spechler, Stuart Jon

“…This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the…”
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In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump by Odiase, Eunice, Zhang, Xi, Chang, Yan, Nelson, Melissa, Balaji, Uthra, Gu, Jinghua, Zhang, Qiuyang, Pan, Zui, Spechler, Stuart Jon, Souza, Rhonda F.

“…In upper airway cells, T helper 2 cytokines that signal through interleukin-4 (IL-4) receptor-α have been shown to stimulate eotaxin-3 secretion via a…”
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Might the Use of Acid-Suppressive Medications Predispose to the Development of Eosinophilic Esophagitis? by NAWAZ MERWAT, Shehzad, JON SPECHLER, Stuart

“…The prevalence of eosinophilic esophagitis, a manifestation of food allergy, has increased in recent years for reasons that are not clear. The gastrointestinal…”
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Can Eosinophilic Esophagitis Cause Achalasia and Other Esophageal Motility Disorders? by Spechler, Stuart Jon, Konda, Vani, Souza, Rhonda

“…Eosinophilic esophagitis (EoE), a disorder identified by its esophageal mucosal features, often is associated with esophageal motility abnormalities, which are…”
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Buried Metaplasia After Endoscopic Ablation of Barrett's Esophagus: A Systematic Review by GRAY, Nathan A, ODZE, Robert D, SPECHLER, Stuart Jon

“…Endoscopic ablation of Barrett's esophagus can bury metaplastic glands under a layer of neosquamous epithelium. To explore the frequency and importance of…”
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Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications by Kedika, Ramalinga R, Souza, Rhonda F, Spechler, Stuart Jon

“…Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, and are widely regarded as the agents of choice for the treatment of acid-peptic…”
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Thoughts on the Complex Relationship Between Gastroesophageal Reflux Disease and Eosinophilic Esophagitis by Spechler, Stuart Jon, Genta, Robert M, Souza, Rhonda F

“…Recent data suggest that the interaction between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis can be complex, and that the notion of…”
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Acid, bile, and CDX: the ABCs of making Barrett's metaplasia by Souza, Rhonda F, Krishnan, Kumar, Spechler, Stuart Jon

“…Barrett's esophagus, a squamous-to-columnar cell metaplasia that develops as a result of chronic gastroesophageal reflux disease (GERD), is a risk factor for…”
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New Eosinophilic Esophagitis Concepts Call for Change in Proton Pump Inhibitor Management Before Diagnostic Endoscopy by Odiase, Eunice, Schwartz, Armond, Souza, Rhonda F., Martin, Jason, Konda, Vani, Spechler, Stuart Jon

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Barrett's Esophagus: Is the Goblet Half Empty? by Spechler, Stuart Jon, MD

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In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids by Peng, Sui, Huo, Xiaofang, Rezaei, Davood, Zhang, Qiuyang, Zhang, Xi, Yu, Chunhua, Asanuma, Kiyotaka, Cheng, Edaire, Pham, Thai H, Wang, David H, Chen, Minhu, Souza, Rhonda F, Spechler, Stuart Jon

“…Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to…”
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Buried (but not dead) Barrett's metaplasia: tales from the crypts by Spechler, Stuart Jon, MD

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Surgery for Gastroesophageal Reflux Disease: Esophageal Impedance to Progress? by Spechler, Stuart Jon, MD

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Controversies in Barrett Esophagus by Dunbar, Kerry B., MD, PhD, Spechler, Stuart Jon, MD

“…Abstract Barrett esophagus develops when metaplastic columnar epithelium predisposed to develop adenocarcinoma replaces esophageal squamous epithelium damaged…”
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Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells by Yu, Chunhua, Zhang, Qiuyang, Zhang, Hui Ying, Zhang, Xi, Huo, Xiaofang, Cheng, Edaire, Wang, David H, Arbiser, Jack L, Spechler, Stuart Jon, Souza, Rhonda F

“…One way to link chronic inflammation with cancer is through the intrinsic inflammatory pathway, in which genetic alterations that induce malignant…”
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Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells by SOUZA, Rhonda F, SHEWMAKE, Kenneth, BEER, David G, CRYER, Byron, SPECHLER, Stuart Jon

“…Adenocarcinoma in Barrett's esophagus has been increasing in incidence at a rapid rate for more than two decades. Cyclooxygenase (COX)-2 appears to play an…”
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Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus by Sarosi, G., Brown, G., Jaiswal, K., Feagins, L. A., Lee, E., Crook, T. W., Souza, R. F., Zou, Y. S., Shay, J. W., Spechler, Stuart Jon

“…Barrett's esophagus develops when refluxed gastric juice injures the esophageal squamous lining and the injury heals through a metaplastic process in which…”
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Management of Nondysplastic Barrett's Esophagus: Where Are We Now? by SHARMA, Prateek, FALK, Gary W, SAMPLINER, Richard, SPECHLER, Stuart Jon, WANG, Kenneth

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Development and Characterization of a Surgical Mouse Model of Reflux Esophagitis and Barrett's Esophagus by Pham, Thai H., Genta, Robert M., Spechler, Stuart Jon, Souza, Rhonda F., Wang, David H.

“…Ideally, an animal model of Barrett's esophagus should recapitulate the human disease histologically and immunohistochemically, and be readily susceptible to…”
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Barrett Esophagus and Risk of Esophageal Cancer: A Clinical Review by Spechler, Stuart Jon

“…IMPORTANCE Barrett esophagus, a complication of gastroesophageal reflux disease (GERD), predisposes patients to esophageal adenocarcinoma, a tumor that has…”
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