Search Results - "Spear, T"

Enteric neuroplasticity and dysmotility in inflammatory disease: key players and possible therapeutic targets by Spear, Estelle T, Mawe, Gary M

“…Intestinal functions, including motility and secretion, are locally controlled by enteric neural networks housed within the wall of the gut. The fidelity of…”
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Free glycogen in vaginal fluids is associated with Lactobacillus colonization and low vaginal pH by Mirmonsef, Paria, Hotton, Anna L, Gilbert, Douglas, Burgad, Derick, Landay, Alan, Weber, Kathleen M, Cohen, Mardge, Ravel, Jacques, Spear, Gregory T

“…Lactobacillus dominates the lower genital tract microbiota of many women, producing a low vaginal pH, and is important for healthy pregnancy outcomes and…”
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The role of bacterial vaginosis and trichomonas in HIV transmission across the female genital tract by Mirmonsef, Paria, Krass, Laurie, Landay, Alan, Spear, Gregory T

“…Bacterial vaginosis (BV) and Trichomonas vaginalis (TV) infections are both very common and are associated with increased risk of sexual transmission of HIV…”
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Glycogen Levels in Undiluted Genital Fluid and Their Relationship to Vaginal pH, Estrogen, and Progesterone by Mirmonsef, Paria, Hotton, Anna L, Gilbert, Douglas, Gioia, Casey J, Maric, Danijela, Hope, Thomas J, Landay, Alan L, Spear, Gregory T

“…Colonization of the female lower genital tract with Lactobacillus provides protection against STIs and adverse pregnancy outcomes. Growth of genital…”
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The prorenin receptor and its soluble form contribute to lipid homeostasis by Gatineau, Eva, Arthur, Gertrude, Poupeau, Audrey, Nichols, Kellea, Spear, Brett T, Shelman, Nathan R, Graf, Gregory A, Temel, Ryan E, Yiannikouris, Frédérique B

“…Obesity is associated with alterations in hepatic lipid metabolism. We previously identified the prorenin receptor (PRR) as a potential contributor to liver…”
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Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535 by Gedaly, Roberto, Galuppo, Roberto, Daily, Michael F, Shah, Malay, Maynard, Erin, Chen, Changguo, Zhang, Xiping, Esser, Karyn A, Cohen, Donald A, Evers, B Mark, Jiang, Jieyun, Spear, Brett T

“…Activation of the Wnt/β-catenin pathway has been observed in at least 1/3 of hepatocellular carcinomas (HCC), and a significant number of these have mutations…”
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CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma by Pascual-Pasto, Guillem, McIntyre, Brendan, Hines, Margaret G., Giudice, Anna M., Garcia-Gerique, Laura, Hoffmann, Jennifer, Mishra, Pamela, Matlaga, Stephanie, Lombardi, Simona, Shraim, Rawan, Schürch, Patrick M., Yarmarkovich, Mark, Hofmann, Ted J., Alikarami, Fatemeh, Martinez, Daniel, Tsang, Matthew, Gil-de-Gómez, Luis, Spear, Timothy T., Bernt, Kathrin M., Wolpaw, Adam J., Dimitrov, Dimiter S., Li, Wei, Bosse, Kristopher R.

“…Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive…”
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Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women's Interagency HIV Study by Daubert, Elizabeth, Weber, Kathleen M, French, Audrey L, Seidman, Dominika, Michel, Katherine, Gustafson, Deborah, Murphy, Kerry, Muzny, Christina A, Alcaide, Maria, Sheth, Anandi, Adimora, Adaora A, Spear, Gregory T

“…The vaginal microbiota is known to impact women's health, but the biological factors that influence the composition of the microbiota are not fully understood…”
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Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis by Spear, E. T., Holt, E. A., Joyce, E. J., Haag, M. M., Mawe, S. M., Hennig, G. W., Lavoie, B., Applebee, A. M., Teuscher, C., Mawe, G. M.

“…Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that, in addition to motor, sensory, and cognitive symptoms, also…”
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Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E by Yue, Xuetian, Zhang, Zhenyu, Liang, Xiaohong, Gao, Lifen, Zhang, Xiaoning, Zhao, Di, Liu, Xiao, Ma, Hongxin, Guo, Min, Spear, Brett T, Gong, Yaoqin, Ma, Chunhong

“…Background & Aims Zinc-fingers and homeoboxes 2 (ZHX2) represses transcription of several genes associated with liver cancer. However, little is known about…”
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How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire by Blevins, Sydney J., Pierce, Brian G., Singh, Nishant K., Riley, Timothy P., Wang, Yuan, Spear, Timothy T., Nishimura, Michael I., Weng, Zhiping, Baker, Brian M.

“…How T-cell receptors (TCRs) can be intrinsically biased toward MHC proteins while simultaneously display the structural adaptability required to engage diverse…”
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The vaginal microbiota over an 8- to 10-year period in a cohort of HIV-infected and HIV-uninfected women by Mehta, Supriya D, Donovan, Brock, Weber, Kathleen M, Cohen, Mardge, Ravel, Jacques, Gajer, Pawel, Gilbert, Douglas, Burgad, Derick, Spear, Greg T

“…We identified predominant vaginal microbiota communities, changes over time, and how this varied by HIV status and other factors in a cohort of 64 women…”
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Spectroscopic investigation of nitrogen doped graphene by Podila, R., Chacón-Torres, J., Spear, J. T., Pichler, T., Ayala, P., Rao, A. M.

“…Current research efforts are aimed at controlling the electronic properties via doping graphene. Previously, dopant-induced changes in the Fermi velocity were…”
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Female Genital-Tract HIV Load Correlates Inversely with Lactobacillus Species but Positively with Bacterial Vaginosis and Mycoplasma hominis by Sha, Beverly E., Zariffard, M. Reza, Wang, Qiong J., Chen, Hua Y., Bremer, James, Cohen, Mardge H., Spear, Gregory T.

“…Background. Bacterial vaginosis (BV) is associated with human immunodeficiency virus (HIV) acquisition. We examined the association between BV and…”
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Effect of pH on Cleavage of Glycogen by Vaginal Enzymes by Spear, Greg T, McKenna, Mary, Landay, Alan L, Makinde, Hadijat, Hamaker, Bruce, French, Audrey L, Lee, Byung-Hoo

“…Glycogen expressed by the lower genital tract epithelium is believed to support Lactobacillus growth in vivo, although most genital isolates of Lactobacillus…”
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Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors by Brudner, Matthew, Karpel, Marshall, Lear, Calli, Chen, Li, Yantosca, L Michael, Scully, Corinne, Sarraju, Ashish, Sokolovska, Anna, Zariffard, M Reza, Eisen, Damon P, Mungall, Bruce A, Kotton, Darrell N, Omari, Amel, Huang, I-Chueh, Farzan, Michael, Takahashi, Kazue, Stuart, Lynda, Stahl, Gregory L, Ezekowitz, Alan B, Spear, Gregory T, Olinger, Gene G, Schmidt, Emmett V, Michelow, Ian C

“…Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly,…”
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Dietary antioxidants in the prevention of hepatocarcinogenesis: A review by Glauert, Howard P, Calfee-Mason, Karen, Stemm, Divinia N, Tharappel, Job C, Spear, Brett T

“…In this review, the role of dietary antioxidants in the prevention of hepatocarcinogenesis is examined. Both human and animal models are discussed. Vitamin C,…”
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Comparison of the Diversity of the Vaginal Microbiota in HIV-Infected and HIV-Uninfected Women with or without Bacterial Vaginosis by Spear, Gregory T., Sikaroodi, Masoumeh, Zariffard, M. Reza, Landay, Alan L., French, Audrey L., Gillevet, Patrick M.

“…Background. Whether human immunodeficiency virus (HIV) infection is associated with a change in the diversity of genital microbiota in women was investigated…”
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Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus by Barisic, Stefan, Brahmbhatt, Elizabeth M, Cherkasova, Elena, Spear, Timothy T, Savani, Ujjawal, Pierre, Stephanie, Scurti, Gina M, Chen, Long, Igboko, Muna, Nadal, Rosa, Zeng, Gang, Parry, Gordon, Stroncek, David F, Highfill, Steven, Dalheim, Annika V, Reger, Robert, Nishimura, Michael I, Childs, Richard W

“…BackgroundWe discovered a novel human endogenous retrovirus (CT-RCC HERV-E) that was selectively expressed in most clear cell renal cell carcinomas (ccRCC) and…”
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Bovine papillomavirus-like particles presenting conserved epitopes from membrane-proximal external region of HIV-1 gp41 induced mucosal and systemic antibodies by Zhai, Yougang, Zhong, Zhenyu, Zariffard, Mohammadreza, Spear, Gregory T, Qiao, Liang

“…Highlights • Chimeric BPV VLP vaccines were constructed to present HIV-1 MPER epitopes. • The induction of systemic and mucosal antibody responses was assessed…”
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