Search Results - "Spear, Linda Patia"

Adolescent Neurodevelopment by Spear, Linda Patia, Ph.D

“…Abstract Purpose The purpose of this article is to outline notable alterations occurring in the adolescent brain, and to consider potential ramifications of…”
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Heightened stress responsivity and emotional reactivity during pubertal maturation: Implications for psychopathology by Spear, Linda Patia

“…This commentary reviews and reflects on the studies of this special section: studies that collectively provide compelling evidence for meaningful changes in…”
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Prenatal ethanol exposure attenuates sensitivity to the aversive effects of ethanol in adolescence and increases adult preference for a 5% ethanol solution in males, but not females by Gore-Langton, Jonathan Kent, Spear, Linda Patia

“…The present set of experiments investigated the effects of a moderate dose of ethanol (2 g/kg; 20% v/v intragastrically) during late gestation (G17–20…”
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Adolescent but Not Adult Rats Exhibit Ethanol-Mediated Appetitive Second-Order Conditioning by Pautassi, Ricardo Marcos, Myers, Mallory, Spear, Linda Patia, Molina, Juan Carlos, Spear, Norman E.

“…Background:  Adolescent rats are less sensitive to the sedative effects of ethanol than older animals. They also seem to perceive the reinforcing properties of…”
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Ontogeny of ethanol-induced motor impairment following acute ethanol: Assessment via the negative geotaxis reflex in adolescent and adult rats by Ramirez, Ruby Liane, Spear, Linda Patia

“…Adolescent rats have been observed to be less sensitive than adults to a number of ethanol effects that may serve as feedback cues to reduce further ethanol…”
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Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats by Varlinskaya, Elena I., Spear, Linda Patia, Diaz, Marvin R.

“…The dynorphin/kappa opioid receptor (DYN/KOR) system has been identified as a primary target of stress due to behavioral effects, such as dysphoria, aversion,…”
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Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence? by Spear, Linda Patia

“…Abstract There are two key alcohol use patterns among human adolescents that confer increased vulnerability for later alcohol abuse/dependence, along with…”
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Effects of ethanol administration on corticosterone levels in adolescent and adult rats by Willey, Amanda Rachel, Anderson, Rachel Ivy, Morales, Melissa, Ramirez, Ruby Liane, Spear, Linda Patia

“…Abstract Adolescent humans and rodents have been shown to consume more alcohol than their adult counterparts. Given that corticosterone (CORT) has been shown…”
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Consequences of adolescent use of alcohol and other drugs: Studies using rodent models by Spear, Linda Patia

“…•Rodent studies reveal persisting neurobehavioral effects of adolescent drug exposure.•Ethanol, nicotine and cannabinoid vulnerability is greater in…”
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Effects of pretest manipulation on elevated plus-maze behavior in adolescent and adult male and female Sprague–Dawley rats by Doremus-Fitzwater, Tamara L., Varlinskaya, Elena I., Spear, Linda Patia

“…The elevated plus-maze (EPM) is vulnerable to variations in pretest circumstances when testing adult rodents. Because of an increasing interest in adolescence,…”
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Timing Eclipses Amount: The Critical Importance of Intermittency in Alcohol Exposure Effects by Spear, Linda Patia

“…Frequency and duration of ethanol (EtOH) exposures influence the consequences of those experiences, with evidence building from basic science studies in rats…”
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Ethanol induces second-order aversive conditioning in adolescent and adult rats by Pautassi, Ricardo Marcos, Myers, Mallory, Spear, Linda Patia, Molina, Juan Carlos, Spear, Norman E

“…Abstract Alcohol abuse and dependence are considered public health problems, with an etiological onset often occurring during late childhood and adolescence,…”
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Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data by Spear, Linda Patia

“…The adolescent transition is associated with increases in reward- and sensation-seeking, peer-directed social interactions, and risk-taking, with exploratory…”
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Adolescents and alcohol: Acute sensitivities, enhanced intake, and later consequences by Spear, Linda Patia

“…Abstract Adolescence is an evolutionarily conserved developmental period characterized by notable maturational changes in the brain along with various…”
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Age-Related Differences in Elevated Plus Maze Behavior between Adolescent and Adult Rats by DOREMUS, TAMARA L., VARLINSKAYA, ELENA I., SPEAR, LINDA PATIA

“…: Adolescence is a time of considerable transformations, often associated with increases in risk taking and novelty‐seeking behaviors. Little is known of a…”
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Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: A mini-review by SPEAR, Linda Patia, SWARTZWELDER, H. Scott

“…Alcohol use is typically initiated during adolescence, which, along with young adulthood, is a vulnerable period for the onset of high-risk drinking and…”
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Rats exposed to intermittent ethanol during late adolescence exhibit enhanced habitual behavior following reward devaluation by Towner, Trevor Theodore, Spear, Linda Patia

“…The brain undergoes substantial maturation during adolescence, and repeated exposure to ethanol at this time has been shown to result in long-lasting…”
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Adolescent Neurobehavioral Characteristics, Alcohol Sensitivities, and Intake: Setting the Stage for Alcohol Use Disorders? by Spear, Linda Patia

“…— The transition to adolescence is characterized by rapid biological transformations that include not only the hormonal and physiological changes of puberty…”
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The effects of age, sex, and handling on behavioral parameters in the multivariate concentric square field™ test by Gore-Langton, Jonathan Kent, Werner, David Francis, Spear, Linda Patia

“…•Handling increases risk taking and reduces shelter seeking.•Females are more exploratory than males.•No age differences in risk taking or risk…”
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Voluntary elevated ethanol consumption in adolescent Sprague-Dawley rats: Procedural contributors and age-specificity by Hosová, Dominika, Spear, Linda Patia

“…Alcohol consumption is typically initiated during adolescence, with the incidence of binge drinking (production of blood ethanol concentrations…”
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