Search Results - "Spear, Abigail M"

Machine learning utilising spectral derivative data improves cellular health classification through hyperspectral infra-red spectroscopy by Mellors, Ben O. L, Spear, Abigail M, Howle, Christopher R, Curtis, Kelly, Macildowie, Sara, Dehghani, Hamid

“…The objective differentiation of facets of cellular metabolism is important for several clinical applications, including accurate definition of tumour…”
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Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock by Francis, Wendy R., Ireland, Rachel E., Spear, Abigail M., Jenner, Dominic, Watts, Sarah A., Kirkman, Emrys, Pallister, Ian

“…Severe injury and hemorrhagic shock (HS) result in multiple changes to hematopoietic differentiation, which contribute to the development of immunosuppression…”
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Bacillus anthracis TIR Domain-Containing Protein Localises to Cellular Microtubule Structures and Induces Autophagy by Carlsson, Emil, Thwaite, Joanne E, Jenner, Dominic C, Spear, Abigail M, Flick-Smith, Helen, Atkins, Helen S, Byrne, Bernadette, Ding, Jeak Ling

“…Toll-like receptors (TLRs) recognise invading pathogens and mediate downstream immune signalling via Toll/IL-1 receptor (TIR) domains. TIR domain proteins…”
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Applications of compressive sensing in spatial frequency domain imaging by Mellors, Ben O. L, Bentley, Alexander, Spear, Abigail M, Howle, Christopher R, Dehghani, Hamid

“…Significance: Spatial frequency domain imaging (SFDI) is an imaging modality that projects spatially modulated light patterns to determine optical property…”
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Bacterial TIR-containing proteins and host innate immune system evasion by Rana, Rohini R., Zhang, Minghao, Spear, Abigail M., Atkins, Helen S., Byrne, Bernadette

“…The innate immune system provides the first line of host defence against invading pathogens. Key to upregulation of the innate immune response are Toll-like…”
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A pre-clinical evaluation of silver, iodine and Manuka honey based dressings in a model of traumatic extremity wounds contaminated with Staphylococcus aureus by Guthrie, Hugo C, Martin, Kevin R, Taylor, Christopher, Spear, Abigail M, Whiting, Rachel, Macildowie, Sara, Clasper, Jonathan C, Watts, Sarah A

“…Abstract Prevention of extremity war wound infection remains a clinical challenge. Staphylococcus aureus is the most common pathogen in delayed infection. We…”
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Microbial TIR domains: not necessarily agents of subversion? by Spear, Abigail M, Loman, Nicholas J, Atkins, Helen S, Pallen, Mark J

“…The Toll/interleukin-1 receptor (TIR) domain plays a crucial role in the mammalian innate immune response. Recently, proteins containing TIR domains have been…”
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Regenerative medicine and war: a front-line focus for UK defence by Spear, Abigail M., Lawton, Graham, Staruch, Robert M. T., Rickard, Rory F.

“…The recent prolonged conflicts in Iraq and Afghanistan saw the advancement of deployed trauma care to a point never before seen in war. The rapid translation…”
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Blast Wave Exposure to the Extremities Causes Endothelial Activation and Damage by Spear, Abigail M, Davies, Emma M, Taylor, Christopher, Whiting, Rachel, Macildowie, Sara, Kirkman, Emrys, Midwinter, Mark, Watts, Sarah A

“…ABSTRACTExtremity injury is a significant burden to those injured in explosive incidents and local ischaemia can result in poor functionality in salvaged…”
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A Toll/interleukin (IL)-1 receptor domain protein from Yersinia pestis interacts with mammalian IL-1/Toll-like receptor pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague by SPEAR, Abigail M, RANA, Rohini R, JENNER, Dominic C, FLICK-SMITH, Helen C, OYSTON, Petra C. F, SIMPSON, Peter, MATTHEWS, Stephen J, BYRNE, Bernadette, ATKINS, Helen S

“…The Toll/interleukin (IL)-1 receptor (TIR) domain is an essential component of eukaryotic innate immune signalling pathways. Interaction between TIR domains…”
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Yersinia pestis TIR-domain protein forms dimers that interact with the human adaptor protein MyD88 by Rana, Rohini R., Simpson, Peter, Zhang, Minghao, Jennions, Matthew, Ukegbu, Chimaka, Spear, Abigail M., Alguel, Yilmaz, Matthews, Stephen J., Atkins, Helen S., Byrne, Bernadette

“…Recent research has highlighted the presence of Toll/Interleukin 1 receptor (TIR)-domain proteins (Tdps) in a range of bacteria, suggested to form interactions…”
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Enhanced vaccine antigen delivery by Salmonella using antibiotic-free operator–repressor titration-based plasmid stabilisation compared to chromosomal integration by Leckenby, Matthew W., Spear, Abigail M., Neeson, Brendan N., Williamson, E. Diane, Cranenburgh, Rocky M., Atkins, Helen S.

“…Live attenuated bacteria provide the potential to replace traditional needle-based vaccination with an orally administered vaccine. The heterologous antigen…”
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Machine learning utilising spectral derivative data improves cellular health classification through hyperspectral infra-red spectroscopy by Ben O L Mellors, Abigail M Spear, Christopher R Howle, Kelly Curtis, Sara Macildowie, Hamid Dehghani

“…The objective differentiation of facets of cellular metabolism is important for several clinical applications, including accurate definition of tumour…”
Get full text