Search Results - "Spealman, Roger D."

Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease by Hallett, Penelope J., Deleidi, Michela, Astradsson, Arnar, Smith, Gaynor A., Cooper, Oliver, Osborn, Teresia M., Sundberg, Maria, Moore, Michele A., Perez-Torres, Eduardo, Brownell, Anna-Liisa, Schumacher, James M., Spealman, Roger D., Isacson, Ole

“…Autologous transplantation of patient-specific induced pluripotent stem cell (iPSC)-derived neurons is a potential clinical approach for treatment of…”
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Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine by Lee, Buyean, Platt, Donna M, Rowlett, James K, Adewale, Adepero S, Spealman, Roger D

“…Growing evidence suggests a role for metabotropic glutamate receptors (mGluRs) in the behavioral effects of cocaine related to its abuse. The mGluR5 subtype,…”
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Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys by Platt, Donna M, Rowlett, James K, Spealman, Roger D

“…Norepinephrine (NE) uptake and NE receptor mechanisms play important modulating roles in the discriminative stimulus and stimulant effects of cocaine. The…”
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Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys by Rowlett, James K, Platt, Donna M, Yao, Wei-Dong, Spealman, Roger D

“…Cocaine-heroin combinations ("speedballs") are commonly self-administered by polydrug abusers. Speedball self-administration may reflect in part an enhancement…”
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The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies by Astradsson, Arnar, Jenkins, Bruce G, Choi, Ji-Kyung, Hallett, Penelope J, Levesque, Michele A, McDowell, Jack S, Brownell, Anna-Liisa, Spealman, Roger D, Isacson, Ole

“…Abstract It has been suggested, based on rodent studies, that levodopa ( l -dopa) induced dyskinesia is associated with a disrupted blood–brain barrier (BBB)…”
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Chronic Δ9-tetrahydrocannabinol exposure in adolescent nonhuman primates: persistent abnormalities in economic demand and brain functional connectivity by Kangas, Brian D., Deshpande, Harshawardhan U., Withey, Sarah L., Spealman, Roger D., Bergman, Jack, Kohut, Stephen J.

“…Although chronic cannabis use during adolescence can alter brain function and impair complex behavioral processes, it is unclear whether such deficits persist…”
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Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment by Withey, Sarah L, Spealman, Roger D, Bergman, Jack, Paronis, Carol A

“…Buprenorphine, a partial agonist at the -opioid receptor, is commonly prescribed for the management of opioid addiction. Notwithstanding buprenorphine's…”
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Dopaminergic signaling in dendritic spines by Yao, Wei-Dong, Spealman, Roger D., Zhang, Jingping

“…Dopamine regulates movement, motivation, reward, and learning and is implicated in numerous neuropsychiatric and neurological disorders. The action of dopamine…”
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Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys by Achat-Mendes, Cindy, Platt, Donna M, Spealman, Roger D

“…Within the group I family of metabotropic glutamate receptors (mGluRs), substantial evidence points to a role for mGluR5 mechanisms in cocaine's abuse-related…”
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Modulation of reinstated polydrug (cocaine/heroin) seeking by noradrenergic α2 agonists by Spealman, Roger D, Bergman, Jack

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Modulation Of Behavioral Effects Of Polydrug (Cocaine/Heroin) Mixtures By Alpha-2 Agonists by Spealman, Roger D, Bergman, Jack

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Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors by Rüedi-Bettschen, Daniela, Spealman, Roger D., Platt, Donna M.

“…Rationale 5-Hydroxytryptamine (5-HT) transport inhibitors can attenuate the abuse-related effects of cocaine, and the mechanisms underlying this attenuation…”
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Pharmacological blockade of α2-Adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys by LEE, Buyean, TIEFENBACHER, Stefan, PLATT, Donna M, SPEALMAN, Roger D

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Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys by Achat-Mendes, Cindy, Grundt, Peter, Cao, Jianjing, Platt, Donna M, Newman, Amy Hauck, Spealman, Roger D

“…Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor…”
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Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine by Platt, Donna M., Rowlett, James K., Spealman, Roger D.

“…Rationale The mGluR5 antagonist MPEP has effects that suggest potential as a pharmacotherapy for cocaine addiction. MPEP can attenuate self-administration of…”
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Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors by Rowlett, James K, Platt, Donna M, Spealman, Roger D

“…In previous studies, heroin was shown to engender cocaine-like discriminative stimulus (DS) effects; however, the mechanisms underlying the cocaine-like…”
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D-cycloserine Deters Reacquisition of Cocaine Self-Administration by Augmenting Extinction Learning by NIC DHONNCHADHA, Brid A, SZALAY, Jonathan J, ACHAT-MENDES, Cindy, PLATT, Donna M, OTTO, Michael W, SPEALMAN, Roger D, KANTAK, Kathleen M

“…Augmentation of cue exposure (extinction) therapy with cognitive-enhancing pharmacotherapy may offer an effective strategy to combat cocaine relapse. To…”
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Cocaine-cue extinction learning in rats: Impact of cocaine training dose and modulation by environmental enrichment by Gauthier, Jamie M, Spealman, Roger D, Kantak, Kathleen M

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Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease by Isacson, Ole, Brownell, Anna-Liisa, Jenkins, Bruce G, Elmaleh, David R, Deacon, Terrence W, Spealman, Roger D

“…We used brain imaging to study long-term neurodegenerative and bioadaptive neurochemical changes in a primate model of Parkinson disease. We gradually induced…”
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Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms by Valdez, Glenn R, Platt, Donna M, Rowlett, James K, Rüedi-Bettschen, Daniela, Spealman, Roger D

“…Kappa opioid agonists were at one time proposed as candidate pharmacotherapies for cocaine addiction, mainly because of their ability to decrease dopamine…”
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