Search Results - "Speake, D."

Meta-analysis of the effect of perioperative intravenous lidocaine on return of gastrointestinal function after colorectal surgery by Cooke, C., Kennedy, E. D., Foo, I., Nimmo, S., Speake, D., Paterson, H. M., Ventham, N. T.

“…Background Return of normal gastrointestinal (GI) function is a critical determinant of recovery after colorectal surgery. The aim of this meta-analysis was to…”
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Management of colonic complications of type IV Ehlers–Danlos syndrome: a systematic review and evidence‐based management strategy by Speake, D., Dvorkin, L., Vaizey, C. J., Carlson, G. L.

“…Aim Type IV Ehlers Danlos Syndrome (EDS) is a connective tissue disorder affecting approximately 1 per 100,000‐200,000 people. Life expectancy is reduced…”
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Multicentre study of short-course radiotherapy and transanal endoscopic microsurgery for early rectal cancer by Smart, C. J., Korsgen, S., Hill, J., Speake, D., Levy, B., Steward, M., Geh, J. I., Robinson, J., Sebag-Montefiore, D., Bach, S. P.

“…Background Organ‐preserving treatment for early‐stage rectal cancer may avoid the substantial perioperative morbidity and functional sequelae associated with…”
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Discovery and Development of α7 Nicotinic Acetylcholine Receptor Modulators by Mazurov, Anatoly A, Speake, Jason D, Yohannes, Daniel

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Contemporary use of social media by consultant colorectal surgeons by McDonald, J. J., Bisset, C., Coleman, M. G., Speake, D., Brady, R. R. W.

“…Aim There is evidence of significant growth in the engagement of UK health‐care professionals with ‘open’ social media platforms, such as Twitter and LinkedIn…”
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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity by Qiao, Liyan, Hamamichi, Shusei, Caldwell, Kim A, Caldwell, Guy A, Yacoubian, Talene A, Wilson, Scott, Xie, Zuo-Lei, Speake, Lisa D, Parks, Rachael, Crabtree, Donna, Liang, Qiuli, Crimmins, Stephen, Schneider, Lonnie, Uchiyama, Yasuo, Iwatsubo, Takeshi, Zhou, Yi, Peng, Lisheng, Lu, YouMing, Standaert, David G, Walls, Ken C, Shacka, John J, Roth, Kevin A, Zhang, Jianhua

“…α-synuclein (α-syn) is a main component of Lewy bodies (LB) that occur in many neurodegenerative diseases, including Parkinson's disease (PD), dementia with LB…”
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Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats by Loram, Lisa C, Taylor, Frederick R, Strand, Keith A, Maier, Steven F, Speake, Jason D, Jordan, Kristen G, James, John W, Wene, Steven P, Pritchard, Robert C, Green, Heather, Van Dyke, Katherine, Mazarov, Anatoly, Letchworth, Sharon R, Watkins, Linda R

“…Alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonists attenuate pain and inflammation in preclinical models. This study tested whether systemic delivery…”
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Conservative management of a caecal volvulus secondary to reversal of loop ileostomy following ultra-low anterior resection by Knight, S. R., Collie, M., Brush, J., Speake, D.

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Desmoid tumours in patients with familial adenomatous polyposis and desmoid region adenomatous polyposis coli mutations by Speake, D., Evans, D. G., Lalloo, F., Scott, N. A., Hill, J.

“…Background: The aim of this study was to determine the proportion of patients with familial adenomatous polyposis (FAP) who had mutations in the desmoid region…”
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Multicentre review of lymph node harvest in colorectal cancer by Mitchell, P. J, Ravi, S, Grifftiths, B, Reid, F, Speake, D, Midgley, C, Mapstone, N

“…Background Lymph node examination in colorectal cancer is of vital importance for accurate staging. Patients who have fewer nodes examined may be understaged…”
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Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists by YUPING GONG, ZHIYANG ZHAO, MCCONN, Donavon J, BEAUDET, Beth, TALLMAN, Melanie, SPEAKE, Jason D, IGNAR, Diane M, KRISE, Jeffrey P

“…A series of melanocortin-4 receptor (MC4R) agonists, developed for use as anti-obesity agents, were found to have unusual pharmacokinetic behavior arising from…”
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Who should be followed up after transanal endoscopic resection of rectal tumours? by Speake, D., Lees, N., McMahon, R. F. T., Hill, J.

“…Objective  To determine follow‐up requirements following transanal endoscopic microsurgery (TEM) for rectal tumours based on clinical and histopathological…”
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3D Molecular Descriptors Important for Clinical Success by Kombo, David C, Tallapragada, Kartik, Jain, Rachit, Chewning, Joseph, Mazurov, Anatoly A, Speake, Jason D, Hauser, Terry A, Toler, Steve

“…The pharmacokinetic and safety profiles of clinical drug candidates are greatly influenced by their requisite physicochemical properties. In particular, it has…”
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Hyperplastic Polyps Are Innocuous Lesions in Hereditary Nonpolyposis Colorectal Cancers by Speake, D., O'Sullivan, J., Evans, D. Gareth, Lalloo, F., Hill, J., McMahon, R. F. T.

“…Aims. To compare methylation profiles, protein expression, and microsatellite instability (MSI) of sporadic, HNPCC, and familial hyperplastic polyps (HPs)…”
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Multicentre review of lymph node harvest in colorectal cancer: Are we understaging colorectal cancer patients? by Mitchell, P. J., Ravi, S., Grifftiths, B., Reid, F., Speake, D., Midgley, C., Mapstone, N.

“…Background Lymph node examination in colorectal cancer is of vital importance for accurate staging. Patients who have fewer nodes examined may be understaged…”
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Inherited association of breast and colorectal cancer: limited role of CHEK2 compared with high-penetrance genes by Naseem, H, Boylan, J, Speake, D, Leask, K, Shenton, A, Lalloo, F, Hill, J, Trump, D, Evans, DGR

“…We assessed the association between breast cancer (BC) and colorectal cancer (CRC) from referral pattern to the Regional Genetics Service including molecular…”
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Management of duodenal involvement in locally advanced colonic carcinoma by Biyani, D. K., Speake, D., Siriwardena, A., Watson, A. J. M.

“…Removal of locally advanced right‐sided colonic carcinoma involving the duodenum can be challenging. There are few data on the optimal surgical approach…”
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Studies directed toward the total synthesis of scytophycin C: Synthesis of the C(1)C(18) fragment of scytophycin C by Grieco, Paul A., Speake, Jason D.

“…The synthesis of the C(1) to C(18) fragment of Scytophycin C is described which features a highly stereoselective carbon Ferrier-type reaction in 3.0 M lithium…”
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First ECG in chest pain by Speake, Doug, Terry, Polly

“…Just before you discharge him you stop to wonder what the sensitivity of the initial 12 lead ECG is in predicting acute myocardial infarction. Search strategy…”
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Discovery of 3‑(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a Novel Highly Selective α4β2 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders by Mazurov, Anatoly A, Miao, Lan, Bhatti, Balwinder S, Strachan, Jon-Paul, Akireddy, Srinivasa, Murthy, Srinivasa, Kombo, David, Xiao, Yun-de, Hammond, Philip, Zhang, Jenny, Hauser, Terry A, Jordan, Kristen G, Miller, Craig H, Speake, Jason D, Gatto, Gregory J, Yohannes, Daniel

“…Diversification of essential nicotinic cholinergic pharmacophoric elements, i.e., cationic center and hydrogen bond acceptor, resulted in the discovery of…”
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