Search Results - "Spatz, M"

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro by Spatz, Jordan M., Wein, Marc N., Gooi, Jonathan H., Qu, Yili, Garr, Jenna L., Liu, Shawn, Barry, Kevin J., Uda, Yuhei, Lai, Forest, Dedic, Christopher, Balcells-Camps, Mercedes, Kronenberg, Henry M., Babij, Philip, Pajevic, Paola Divieti

“…Although bone responds to its mechanical environment, the cellular and molecular mechanisms underlying the response of the skeleton to mechanical unloading are…”
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Serum Sclerostin Increases in Healthy Adult Men during Bed Rest by Spatz, J. M, Fields, E. E, Yu, E. W, Pajevic, P. Divieti, Bouxsein, M. L, Sibonga, J. D, Zwart, S. R, Smith, S. M

“…Context: Animal models and human studies suggest that osteocytes regulate the skeleton's response to mechanical unloading in part by an increase in sclerostin…”
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Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading by Spatz, Jordan M, Ellman, Rachel, Cloutier, Alison M, Louis, Leeann, van Vliet, Miranda, Suva, Larry J, Dwyer, Denise, Stolina, Marina, Ke, Hua Zhu, Bouxsein, Mary L

“…Sclerostin, a product of the SOST gene produced mainly by osteocytes, is a potent negative regulator of bone formation that appears to be responsive to…”
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Osteocyte‐Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots by Fulzele, Keertik, Lai, Forest, Dedic, Christopher, Saini, Vaibhav, Uda, Yuhei, Shi, Chao, Tuck, Padrig, Aronson, Jenna L, Liu, Xiaolong, Spatz, Jordan M, Wein, Marc N, Divieti Pajevic, Paola

“…ABSTRACT Cells of the osteoblast lineage are increasingly identified as participants in whole‐body metabolism by primarily targeting pancreatic insulin…”
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Human immune system adaptations to simulated microgravity revealed by single-cell mass cytometry by Spatz, J. M., Fulford, M. Hughes, Tsai, A., Gaudilliere, D., Hedou, J., Ganio, E., Angst, M., Aghaeepour, N., Gaudilliere, Brice

“…Exposure to microgravity (µG) during space flights produces a state of immunosuppression, leading to increased viral shedding, which could interfere with long…”
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Global transcriptomic analysis of a murine osteocytic cell line subjected to spaceflight by Uda, Yuhei, Spatz, Jordan M., Hussein, Amira, Garcia, Joseph H., Lai, Forest, Dedic, Chris, Fulzele, Keertik, Dougherty, Sean, Eberle, Margaret, Adamson, Chris, Misener, Lowell, Gerstenfeld, Louis, Divieti Pajevic, Paola

“…Bone loss is a major health concern for astronauts during long‐term spaceflight and for patients during prolonged bed rest or paralysis. Growing evidence…”
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Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes by Zhu, Ji, Siclari, Valerie A, Liu, Fei, Spatz, Jordan M, Chandra, Abhishek, Divieti Pajevic, Paola, Qin, Ling

“…Intermittent administration of parathyroid hormone (PTH) dramatically increases bone mass and currently is one of the most effective treatments for…”
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RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice by Spatz, Jordan M, Ko, Frank C, Ayturk, Ugur M, Warman, Matthew L, Bouxsein, Mary L

“…Disuse-induced bone loss is seen following spinal cord injury, prolonged bed rest, and exposure to microgravity. We performed whole transcriptomic profiling of…”
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Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss by Uda, Yuhei, Saini, Vaibhav, Petty, Christopher A, Alshehri, Majed, Shi, Chao, Spatz, Jordan M, Santos, Roberto, Newell, Carly M, Huang, Tim Y, Kochen, Alejandro, Kim, Ji W, Constantinou, Christodoulos K, Saito, Hiroaki, Held, Kathryn D, Hesse, Eric, Pajevic, Paola Divieti

“…Aging is accompanied by osteopenia, characterized by reduced bone formation and increased bone resorption. Osteocytes, the terminally differentiated…”
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Endothelial progenitor cells correlate with lesion volume and growth in acute stroke by BOGOSLOVSKY, T, CHAUDHRY, A, LATOUR, L, MARIC, D, LUBY, M, SPATZ, M, FRANK, J, WARACH, S

“…Circulating endothelial progenitor cells (EPC) are markers of vascular injury and their numbers decrease in acute stroke. However, the relation of EPC levels…”
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Fecal excretion of Maillard reaction products and the gut microbiota composition of rats fed with bread crust or bread crumb by Helou, C, Anton, P M, Niquet-Léridon, C, Spatz, M, Tessier, F J, Gadonna-Widehem, P

“…A comparison between the impacts of advanced (N -carboxymethyllysine - CML) and terminal (melanoidins) Maillard reaction products from bread on gut microbiota…”
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Role of c-Met/β1 integrin complex in the metastatic cascade in breast cancer by Lau, Darryl, Wadhwa, Harsh, Sudhir, Sweta, Chang, Alexander Chih-Chieh, Jain, Saket, Chandra, Ankush, Nguyen, Alan T, Spatz, Jordan M, Pappu, Ananya, Shah, Sumedh S, Cheng, Justin, Safaee, Michael M, Yagnik, Garima, Jahangiri, Arman, Aghi, Manish K

“…Metastases cause 90% of human cancer deaths. The metastatic cascade involves local invasion, intravasation, extravasation, metastatic site colonization, and…”
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Binding and neutralization efficiencies of monoclonal antibodies, Fab fragments, and scFv specific for L1 epitopes on the capsid of infectious HPV particles by Culp, Timothy D, Spatz, Christin M, Reed, Cynthia A, Christensen, Neil D

“…Abstract We compared the neutralization abilities of individual monoclonal antibodies (MAb) of two large panels reactive with L1 epitopes of HPV-11 or HPV-16…”
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Endothelial-mediated regulation of cerebral microcirculation by McCarron, R M, Chen, Y, Tomori, T, Strasser, A, Mechoulam, R, Shohami, E, Spatz, M

“…Vascular endothelial cells are important not only for maintaining homeostasis, but also in pathogenesis of vascular disorders. Cerebral capillary and…”
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Sequential Stem Cell–Kidney Transplantation in Schimke Immuno-osseous Dysplasia by Bertaina, Alice, Grimm, Paul C., Weinberg, Kenneth, Parkman, Robertson, Kristovich, Karen M., Barbarito, Giulia, Lippner, Elizabeth, Dhamdhere, Girija, Ramachandran, Vasavi, Spatz, Jordan M., Fathallah-Shaykh, Sahar, Atkinson, T. Prescott, Al-Uzri, Amira, Aubert, Geraldine, van der Elst, Kim, Green, Sean G., Agarwal, Rajni, Slepicka, Priscila F., Shah, Ami J., Roncarolo, Maria G., Gallo, Amy, Concepcion, Waldo, Lewis, David B.

“…Lifelong immunosuppression is required for allograft survival after kidney transplantation but may not ultimately prevent allograft loss resulting from chronic…”
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Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk by Kim, Han W, Van Assche, Lowie, Jennings, Robert B, Wince, W Benjamin, Jensen, Christoph J, Rehwald, Wolfgang G, Wendell, David C, Bhatti, Lubna, Spatz, Deneen M, Parker, Michele A, Jenista, Elizabeth R, Klem, Igor, Crowley, Anna Lisa C, Chen, Enn-Ling, Judd, Robert M, Kim, Raymond J

“…RATIONALE:After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been…”
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The relationship of the transmural extent of T2-edema compared with the transmural extent of infarction: implications for the assessment of the area-at-risk by Kim, Han W, Wince, Ben, van Assche, Lowie, Rehwald, Wolfgang G, Bhatti, Lubna B, Spatz, Deneen M, Klem, Igor, Kim, Raymond J

“…Additionally, basic physiology studies have established that the area-at-risk is not simply larger than the region of infarction, but is nearly always…”
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ET-1- and NO-mediated signal transduction pathway in human brain capillary endothelial cells by Chen, Y, McCarron, R M, Golech, S, Bembry, J, Ford, B, Lenz, F A, Azzam, N, Spatz, M

“…Previous studies have demonstrated that functional interaction between endothelin (ET)-1 and nitric oxide (NO) involves changes in Ca(2+) mobilization and…”
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Combined Effects of Botulinum Toxin Injection and Hind Limb Unloading on Bone and Muscle by Ellman, Rachel, Grasso, Daniel J., van Vliet, Miranda, Brooks, Daniel J., Spatz, Jordan M., Conlon, Christine, Bouxsein, Mary L.

“…Bone receives mechanical stimulation from two primary sources, muscle contractions and external gravitational loading; but the relative contribution of each…”
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Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo by He, Qing, Bouley, Richard, Liu, Zun, Wein, Marc N., Zhu, Yan, Spatz, Jordan M., Wang, Chia-Yu, Pajevic, Paola Divieti, Plagge, Antonius, Babitt, Jodie L., Bastepe, Murat

“…Alterations in the activity/levels of the extralarge G protein α-subunit (XLαs) are implicated in various human disorders, such as perinatal growth…”
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