Search Results - "Spatz, Joachim"

Mastering Complexity: Towards Bottom-up Construction of Multifunctional Eukaryotic Synthetic Cells by Göpfrich, Kerstin, Platzman, Ilia, Spatz, Joachim P.

“…With the ultimate aim to construct a living cell, bottom-up synthetic biology strives to reconstitute cellular phenomena in vitro – disentangled from the…”
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Division and Regrowth of Phase‐Separated Giant Unilamellar Vesicles by Dreher, Yannik, Jahnke, Kevin, Bobkova, Elizaveta, Spatz, Joachim P., Göpfrich, Kerstin

“…Success in the bottom‐up assembly of synthetic cells will depend on strategies for the division of protocellular compartments. Here, we describe the controlled…”
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Environmental sensing through focal adhesions by Bershadsky, Alexander D, Geiger, Benjamin, Spatz, Joachim P

“…Key Points The aim of this Review is to discuss how molecular research into the complex interplay between cell adhesion and the cytoskeleton, combined with…”
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Can Bottom-Up Synthetic Biology Generate Advanced Drug-Delivery Systems? by Lussier, Felix, Staufer, Oskar, Platzman, Ilia, Spatz, Joachim P.

“…Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy cells remains one of the most ambitious objectives in pharmacology…”
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Machine-Learning-Driven Surface-Enhanced Raman Scattering Optophysiology Reveals Multiplexed Metabolite Gradients Near Cells by Lussier, Félix, Missirlis, Dimitris, Spatz, Joachim P, Masson, Jean-François

“…The extracellular environment is a complex medium in which cells secrete and consume metabolites. Molecular gradients are thereby created near cells,…”
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4D Printing of Shape Memory Polymers: From Macro to Micro by Spiegel, Christoph A., Hackner, Maximilian, Bothe, Viktoria P., Spatz, Joachim P., Blasco, Eva

“…A novel and versatile shape memory ink system allowing 4D printing with light at the macroscale as well as the microscale is presented. Digital light…”
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Nanopatterned Adhesive, Stretchable Hydrogel to Control Ligand Spacing and Regulate Cell Spreading and Migration by Deng, Jie, Zhao, Changsheng, Spatz, Joachim P, Wei, Qiang

“…Spatial molecular patterning enables the regulation of adhesion receptor clustering and can thus play a pivotal role in multiple biological activities such as…”
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Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives by Vishwakarma, Medhavi, Di Russo, Jacopo, Probst, Dimitri, Schwarz, Ulrich S., Das, Tamal, Spatz, Joachim P.

“…Regulating the emergence of leaders is a central aspect of collective cell migration, but the underlying mechanisms remain ambiguous. Here we show that the…”
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A molecular mechanotransduction pathway regulates collective migration of epithelial cells by Das, Tamal, Safferling, Kai, Rausch, Sebastian, Grabe, Niels, Boehm, Heike, Spatz, Joachim P.

“…Collective movement of epithelial cells drives essential multicellular organization during various fundamental physiological processes encompassing embryonic…”
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Bottom‐Up Assembly of Functional Intracellular Synthetic Organelles by Droplet‐Based Microfluidics by Staufer, Oskar, Schröter, Martin, Platzman, Ilia, Spatz, Joachim P.

“…Bottom‐up synthetic biology has directed most efforts toward the construction of artificial compartmentalized systems that recreate living cell functions in…”
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Exploiting Noncovalent Interactions in an Imine-Based Covalent Organic Framework for Quercetin Delivery by Vyas, Vijay S., Vishwakarma, Medhavi, Moudrakovski, Igor, Haase, Frederik, Savasci, Gökcen, Ochsenfeld, Christian, Spatz, Joachim P., Lotsch, Bettina V.

“…Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug‐delivery vehicles with high loading capacity and…”
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Cyclic tensile strain controls cell shape and directs actin stress fiber formation and focal adhesion alignment in spreading cells by Greiner, Alexandra M, Chen, Hao, Spatz, Joachim P, Kemkemer, Ralf

“…The actin cytoskeleton plays a crucial role for the spreading of cells, but is also a key element for the structural integrity and internal tension in cells…”
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In vitro cancer cell–ECM interactions inform in vivo cancer treatment by Holle, Andrew W., Young, Jennifer L., Spatz, Joachim P.

“…The general progression of cancer drug development involves in vitro testing followed by safety and efficacy evaluation in clinical trials. Due to the expense…”
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Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics by Weiss, Marian, Frohnmayer, Johannes Patrick, Benk, Lucia Theresa, Haller, Barbara, Janiesch, Jan-Willi, Heitkamp, Thomas, Börsch, Michael, Lira, Rafael B., Dimova, Rumiana, Lipowsky, Reinhard, Bodenschatz, Eberhard, Baret, Jean-Christophe, Vidakovic-Koch, Tanja, Sundmacher, Kai, Platzman, Ilia, Spatz, Joachim P.

“…Compartments for the spatially and temporally controlled assembly of biological processes are essential towards cellular life. Synthetic mimics of cellular…”
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Bottom-Up Assembly of Bioinspired, Fully Synthetic Extracellular Vesicles by Macher, Meline, Platzman, Ilia, Spatz, Joachim P

“…Extracellular vesicles (EVs) are lipid membrane-enclosed compartments released by cells for intercellular communication in homeostasis and disease. Studies…”
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Combined Effects of PEG Hydrogel Elasticity and Cell-Adhesive Coating on Fibroblast Adhesion and Persistent Migration by Missirlis, Dimitris, Spatz, Joachim P

“…The development and use of synthetic, cross-linked, macromolecular substrates with tunable elasticity has been instrumental in revealing the mechanisms by…”
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Mechanobiology of leader–follower dynamics in epithelial cell migration by Vishwakarma, Medhavi, Spatz, Joachim P., Das, Tamal

“…Collective cell migration is fundamental to biological form and function. It is also relevant to the formation and repair of organs and to various pathological…”
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Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels by Hadden, William J., Young, Jennifer L., Holle, Andrew W., McFetridge, Meg L., Kim, Du Yong, Wijesinghe, Philip, Taylor-Weiner, Hermes, Wen, Jessica H., Lee, Andrew R., Bieback, Karen, Vo, Ba-Ngu, Sampson, David D., Kennedy, Brendan F., Spatz, Joachim P., Engler, Adam J., Choi, Yu Suk

“…The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the…”
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Cancer Cells Invade Confined Microchannels via a Self-Directed Mesenchymal-to-Amoeboid Transition by Holle, Andrew W, Govindan Kutty Devi, Neethu, Clar, Kim, Fan, Anthony, Saif, Taher, Kemkemer, Ralf, Spatz, Joachim P

“…Cancer cell invasion through physical barriers in the extracellular matrix (ECM) requires a complex synergy of traction force against the ECM, mechanosensitive…”
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Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures by Catt, Samantha O., Hackner, Maximillian, Spatz, Joachim P., Blasco, Eva

“…Macromolecules with complex, defined structures exist in nature but rarely is this degree of control afforded in synthetic macromolecules. Sequence‐defined…”
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