Search Results - "Spatz, Alain"

Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline by Garbe, Claus, Peris, Ketty, Hauschild, Axel, Saiag, Philippe, Middleton, Mark, Spatz, Alain, Grob, Jean-Jacques, Malvehy, Josep, Newton-Bishop, Julia, Stratigos, Alexander, Pehamberger, Hubert, Eggermont, Alexander

“…Abstract Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumour and causes 90% of skin cancer mortality. A unique collaboration of…”
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Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial by Eggermont, Alexander MM, Prof, Suciu, Stefan, PhD, Santinami, Mario, MD, Testori, Alessandro, MD, Kruit, Wim HJ, MD, Marsden, Jeremy, MD, Punt, Cornelis JA, Prof, Salès, François, MD, Gore, Martin, Prof, MacKie, Rona, Prof, Kusic, Zvonko, Prof, Dummer, Reinhard, Prof, Hauschild, Axel, Prof, Musat, Elena, MD, Spatz, Alain, MD, Keilholz, Ulrich, Prof

“…Summary Background Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment. Our aim was to determine whether…”
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Dermatologic symptoms associated with the multikinase inhibitor sorafenib by Robert, Caroline, MD, PhD, Mateus, Christina, MD, Spatz, Alain, MD, Wechsler, Janine, MD, Escudier, Bernard, MD

“…Background The multikinase inhibitor sorafenib (Nexavar) is associated with a relatively high incidence of dermatologic symptoms. Objective We sought to…”
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Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib by Arnault, Jean Philippe, Wechsler, Janine, Escudier, Bernard, Spatz, Alain, Tomasic, Gorana, Sibaud, Vincent, Aractingi, Selim, Grange, Jean-Didier, Poirier-Colame, Vichnou, Malka, David, Soria, Jean-Charles, Mateus, Christine, Robert, Caroline

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Skin Tumors Induced by Sorafenib; Paradoxic RAS―RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1 by ARNAULT, Jean Philippe, MATEUS, Christine, ANDRE, Jocelyne, KAMSU-KOM, Nyam, BOUSSEMART, Lise, LACROIX, Ludovic, SPATZ, Alain, EGGERMONT, Alexander M, DRUILLENNEC, Sabine, VAGNER, Stephan, EYCHENE, Alain, DUMAZ, Nicolas, ESCUDIER, Bernard, ROBERT, Caroline, TOMASIC, Gorana, WECHSLER, Janine, HOLLVILLE, Emilie, SORIA, Jean-Charles, MALKA, David, SARASIN, Alain, LARCHER, Magalie

“…The emergence of skin tumors in patients treated with sorafenib or with more recent BRAF inhibitors is an intriguing and potentially serious event. We carried…”
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Cutaneous side-effects of kinase inhibitors and blocking antibodies by Robert, Caroline, Soria, Jean-Charles, Spatz, Alain, Le Cesne, Axel, Malka, David, Pautier, Patricia, Wechsler, Janine, Lhomme, Catherine, Escudier, Bernard, Boige, Valérie, Armand, Jean-Pierre, Le Chevalier, Thierry

“…Although kinase inhibitors raise hope for people with cancer, patients and their clinicians are commonly confronted with the cutaneous side-effects that are…”
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Gene Expression Profiling of Primary Cutaneous Melanoma and Clinical Outcome by Winnepenninckx, Véronique, Lazar, Vladimir, Michiels, Stefan, Dessen, Philippe, Stas, Marguerite, Alonso, Soledad R., Avril, Marie-Françoise, Ortiz Romero, Pablo L., Robert, Thomas, Balacescu, Ovidiu, Eggermont, Alexander M. M., Lenoir, Gilbert, Sarasin, Alain, Tursz, Thomas, van den Oord, Joost J., Spatz, Alain

“…Background: Gene expression profiling data for human primary cutaneous melanomas are scarce because of the lack of retrospective collections of frozen tumors…”
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X-Chromosome Genetics and Human Cancer by Feunteun, Jean, Spatz, Alain, Borg, Christophe

“…In mammals, the X chromosome is unique within the chromosome set. In contrast to the other chromosomes -- for which two active copies are present -- both male…”
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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial by Escudier, Bernard, Dorval, Thierry, Chaput, Nathalie, André, Fabrice, Caby, Marie-Pierre, Novault, Sophie, Flament, Caroline, Leboulaire, Christophe, Borg, Christophe, Amigorena, Sebastian, Boccaccio, Catherine, Bonnerot, Christian, Dhellin, Olivier, Movassagh, Mojgan, Piperno, Sophie, Robert, Caroline, Serra, Vincent, Valente, Nancy, Le Pecq, Jean-Bernard, Spatz, Alain, Lantz, Olivier, Tursz, Thomas, Angevin, Eric, Zitvogel, Laurence

“…BACKGROUND: DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor…”
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Adjuvant Therapy With Pegylated Interferon Alfa-2b Versus Observation in Resected Stage III Melanoma: A Phase III Randomized Controlled Trial of Health-Related Quality of Life and Symptoms by the European Organisation for Research and Treatment of Cancer Melanoma Group by BOTTOMLEY, Andrew, COENS, Corneel, MACKIE, Rona, KUSIC, Zvonko, DUMMER, Reinhard, PATEL, Poulam, SCHADENDORF, Dirk, SPATZ, Alain, KEILHOLZ, Ulrich, EGGERMONT, Alexander, SUCIU, Stefan, SANTINAMI, Mario, KRUIT, Willem, TESTORI, Alessandro, MARSDEN, Jeremy, PUNT, Cornelis, SALES, François, GORE, Martin

“…Interferon (IFN) -based adjuvant therapy in melanoma is associated with significant side effects, which necessitates evaluation of health-related quality of…”
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Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell–dependent antitumor effects by Borg, Christophe, Terme, Magali, Taïeb, Julien, Ménard, Cédric, Flament, Caroline, Robert, Caroline, Maruyama, Koji, Wakasugi, Hiro, Angevin, Eric, Thielemans, Kris, Cesne, Axel Le, Chung-Scott, Véronique, Lazar, Vladimir, Tchou, Isabelle, Crépineau, Florent, Lemoine, François, Bernard, Jacky, Fletcher, Jonhantan A., Turhan, Ali, Blay, Jean-Yves, Spatz, Alain, Emile, Jean-François, Heinrich, Michael C., Mécheri, Salah, Tursz, Thomas, Zitvogel, Laurence

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Phase III Trial Comparing Adjuvant Treatment With Pegylated Interferon Alfa-2b Versus Observation: Prognostic Significance of Autoantibodies—EORTC 18991 by BOUWHUIS, Marna G, SUCIU, Stefan, EGGERMONT, Alexander M. M, TESTORI, Alessandro, KRUIT, Wim H, SALES, François, PATEL, Poulam, PUNT, Cornelis J, SANTINAMI, Mario, SPATZ, Alain, TEN HAGEN, Timo L. M

“…Conflicting data have been reported concerning the prognostic value of autoimmune antibodies in patients with melanoma treated with adjuvant interferon alfa-2b…”
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Dendritic cell derived-exosomes: biology and clinical implementations by Chaput, Nathalie, Flament, Caroline, Viaud, Sophie, Taieb, Julien, Roux, Stephan, Spatz, Alain, André, Fabrice, LePecq, Jean‐Bernard, Boussac, Muriel, Garin, Jérôme, Amigorena, Sebastian, Théry, Clotilde, Zitvogel, Laurence

“…Exosomes are nanometer‐sized membrane vesicles invaginating from multivesicular bodies and secreted from different cell types. They represent an “in vitro”…”
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Prospective study of the cutaneous adverse effects of sorafenib, a novel multikinase inhibitor by Autier, Julien, Escudier, Bernard, Wechsler, Janine, Spatz, Alain, Robert, Caroline

“…To provide an accurate description and to evaluate the incidence and severity of cutaneous reactions induced by sorafenib tosylate, a new oral multikinase…”
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Long-Term Protective Effect of Mature DC-LAMP+ Dendritic Cell Accumulation in Sentinel Lymph Nodes Containing Micrometastatic Melanoma by ELLIOTT, Bruce, SCOLYER, Richard A, TESTORI, Alessandro, EGGERMONT, Alexander, MACKIE, Rona, ROBERT, Caroline, COOK, Martin, THOMPSON, John F, ANGEVIN, Eric, SPATZ, Alain, SUCIU, Stefan, LEBECQUE, Serge, RIMOLDI, Donata, GUGERLI, Oliver, MUSAT, Elena, SHARMA, Raghwa N, LIENARD, Danielle, KEILHOLZ, Ulrich

“…Purpose: In a previous immunohistochemical study of dendritic cells (DC) in sentinel lymph nodes (SLN) draining regressing melanomas, we found that the…”
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Factors to keep in mind when introducing virtual microscopy by GLATZ-KRIEGER, Katharina, SPORNITZ, Udo, SPATZ, Alain, MIHATSCH, Michael J, GLATZ, Dieter

“…Digitization of glass slides and delivery of so-called virtual slides (VS) emulating a real microscope over the Internet have become reality due to recent…”
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Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: Final results of a randomised phase III study (EORTC 18032) by Patel, Poulam M, Suciu, Stefan, Mortier, Laurent, Kruit, Wim H, Robert, Caroline, Schadendorf, Dirk, Trefzer, Uwe, Punt, Cornelis J.A, Dummer, Reinhard, Davidson, Neville, Becker, Juergen, Conry, Robert, Thompson, John A, Hwu, Wen-Jen, Engelen, Kristel, Agarwala, Sanjiv S, Keilholz, Ulrich, Eggermont, Alexander M.M, Spatz, Alain

“…Abstract Purpose To compare the efficacy of an extended schedule escalated dose of temozolomide versus standard dose dacarbazine in a large population of…”
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Prognosis in Patients With Sentinel Node–Positive Melanoma Is Accurately Defined by the Combined Rotterdam Tumor Load and Dewar Topography Criteria by VAN DER PLOEG, Augustinus P. T, VAN AKKOOI, Alexander C. J, VAN DEN HOUT, Mari F. C. M, VAN LEEUWEN, Paul A. M, VOIT, Christiane A, CATALDO, Francesco, TESTORI, Alessandro, ROBERT, Caroline, HOEKSTRA, Harald J, VERHOEF, Cornelis, SPATZ, Alain, EGGERMONT, Alexander M. M, RUTKOWSKI, Piotr, NOWECKI, Zbigniew I, MICHEJ, Wanda, MITRA, Angana, NEWTON-BISHOP, Julia A, COOK, Martin, VAN DER PLOEG, Iris M. C, NIEWEG, Omgo E

“…Prognosis in patients with sentinel node (SN)-positive melanoma correlates with several characteristics of the metastases in the SN such as size and site…”
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INV 7 Primary melanomas with metastatic potential by Spatz, Alain

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EANM-EORTC general recommendations for sentinel node diagnostics in melanoma by Chakera, Annette H., Hesse, Birger, Burak, Zeynep, Ballinger, James R., Britten, Allan, Caracò, Corrado, Cochran, Alistair J., Cook, Martin G., Drzewiecki, Krzysztof T., Essner, Richard, Even-Sapir, Einat, Eggermont, Alexander M. M., Gmeiner Stopar, Tanja, Ingvar, Christian, Mihm, Martin C., McCarthy, Stanley W., Mozzillo, Nicola, Nieweg, Omgo E., Scolyer, Richard A., Starz, Hans, Thompson, John F., Trifirò, Giuseppe, Viale, Giuseppe, Vidal-Sicart, Sergi, Uren, Roger, Waddington, Wendy, Chiti, Arturo, Spatz, Alain, Testori, Alessandro

“…The accurate diagnosis of a sentinel node in melanoma includes a sequence of procedures from different medical specialities (nuclear medicine, surgery,…”
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