Search Results - "Spath, Katharina"

Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid–aneuploid blastocysts by Fragouli, Elpida, Alfarawati, Samer, Spath, Katharina, Babariya, Dhruti, Tarozzi, Nicoletta, Borini, Andrea, Wells, Dagan

“…Preimplantation genetic testing for aneuploidy (PGT-A) is widely used in IVF and aims to improve outcomes by avoiding aneuploid embryo transfers. Chromosomal…”
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The origin and impact of embryonic aneuploidy by Fragouli, Elpida, Alfarawati, Samer, Spath, Katharina, Jaroudi, Souraya, Sarasa, Jonas, Enciso, Maria, Wells, Dagan

“…Despite the clinical importance of aneuploidy, surprisingly little is known concerning its impact during the earliest stages of human development. This study…”
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Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential by Fragouli, Elpida, Spath, Katharina, Alfarawati, Samer, Kaper, Fiona, Craig, Andrew, Michel, Claude-Edouard, Kokocinski, Felix, Cohen, Jacques, Munne, Santiago, Wells, Dagan

“…Mitochondria play a vital role in embryo development. They are the principal site of energy production and have various other critical cellular functions…”
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Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study by Fragouli, Elpida, McCaffrey, Caroline, Ravichandran, Krithika, Spath, Katharina, Grifo, James A, Munné, Santiago, Wells, Dagan

“…Abstract STUDY QUESTION Can quantification of mitochondrial DNA (mtDNA) in trophectoderm (TE) biopsy samples provide information concerning the viability of a…”
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Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice by Costa-Borges, Nuno, Spath, Katharina, Miguel-Escalada, Irene, Mestres, Enric, Balmaseda, Rosa, Serafín, Anna, Garcia-Jiménez, Maria, Vanrell, Ivette, González, Jesús, Rink, Klaus, Wells, Dagan, Calderón, Gloria

“…The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer…”
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Characterization and quantification of proteins secreted by single human embryos prior to implantation by Poli, Maurizio, Ori, Alessandro, Child, Tim, Jaroudi, Souraya, Spath, Katharina, Beck, Martin, Wells, Dagan

“…The use of in vitro fertilization (IVF) has revolutionized the treatment of infertility and is now responsible for 1–5% of all births in industrialized…”
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"Direct cloning in Lactobacillus plantarum: electroporation with non-methylated plasmid DNA enhances transformation efficiency and makes shuttle vectors obsolete" by Spath, Katharina, Heinl, Stefan, Grabherr, Reingard

“…Lactic acid bacteria (LAB) play an important role in agricultural as well as industrial biotechnology. Development of improved LAB strains using e.g. library…”
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First pilot study of maternal spindle transfer for the treatment of repeated in vitro fertilization failures in couples with idiopathic infertility by Costa-Borges, Nuno, Nikitos, Eros, Späth, Katharina, Miguel-Escalada, Irene, Ma, Hong, Rink, Klaus, Coudereau, Clement, Darby, Hayley, Koski, Amy, Van Dyken, Crystal, Mestres, Enric, Papakyriakou, Evmorfia, De Ziegler, Dominique, Kontopoulos, George, Mantzavinos, Themistoklis, Vasilopoulos, Ioannis, Grigorakis, Stylianos, Prokopakis, Thomas, Dimitropoulos, Konstantinos, Polyzos, Panagiotis, Vlachos, Nikolas, Kostaras, Konstantinos, Mitalipov, Shoukhrat, Calderón, Gloria, Psathas, Panagiotis, Wells, Dagan

“…To gain insights into the technical feasibility of maternal spindle transfer (MST) applied in the context of repeated in vitro fertilization (IVF) failures for…”
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Clinical application of sequencing-based methods for parallel preimplantation genetic testing for mitochondrial DNA disease and aneuploidy by Spath, Katharina, Babariya, Dhruti, Konstantinidis, Michalis, Lowndes, Jo, Child, Tim, Grifo, James A., Poulton, Joanna, Wells, Dagan

“…To validate and apply a strategy permitting parallel preimplantation genetic testing (PGT) for mitochondrial DNA (mtDNA) disease and aneuploidy (PGT-A)…”
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In an Ovine Model of Polycystic Ovary Syndrome (PCOS) Prenatal Androgens Suppress Female Fetal Renal Gluconeogenesis by Connolly, Fiona, Rae, Michael T, Späth, Katharina, Boswell, Lyndsey, McNeilly, Alan S, Duncan, W Colin

“…Increased maternal androgen exposure during pregnancy programmes a polycystic ovary syndrome (PCOS)-like condition, with metabolic dysfunction, in adult female…”
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Predicting risk of endometrial failure: a biomarker signature that identifies a novel disruption independent of endometrial timing in patients undergoing hormonal replacement cycles by Diaz-Gimeno, Patricia, Sebastian-Leon, Patricia, Spath, Katharina, Marti-Garcia, Diana, Sanchez-Reyes, Josefa Maria, Vidal, Maria del Carmen, Devesa-Peiro, Almudena, Sanchez-Ribas, Immaculada, Martinez-Martinez, Asunta, Pellicer, Nuria, Wells, Dagan, Pellicer, Antonio

“…To propose a new gene expression signature that identifies endometrial disruptions independent of endometrial luteal phase timing and predicts if patients are…”
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Corrigendum. Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study by Fragouli, Elpida, McCaffrey, Caroline, Ravichandran, Krithika, Spath, Katharina, Grifo, James A, Munné, Santiago, Wells, Dagan

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Clinical application of a protocol based on universal next-generation sequencing for the diagnosis of beta-thalassaemia and sickle cell anaemia in preimplantation embryos by Kubikova, Nada, Babariya, Dhruti, Sarasa, Jonas, Spath, Katharina, Alfarawati, Samer, Wells, Dagan

“…Mutations of the beta-globin gene (HBB) cause beta-thalassaemia and sickle cell anaemia. These are the most common cause of severe inherited disease in humans…”
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A NEW ENDOMETRIAL TRANSCRIPTOMIC STRATIFICATION IN THE MID-SECRETORY PHASE REVEALS A NEW TAXONOMY FOR ENDOMETRIAL PROGNOSIS IN INFERTILITY by Sanchez-Reyes, Josefa Maria, Parraga-Leo, Antonio, León, Patricia Sebastián, Spath, Katharina, Vidal, Carmen, Gorriz-Belert, Manuel, Devesa-Peiro, Almudena, Gimenez, Jose Remohi, Wells, Dagan, Pellicer, Antonio, Gimeno, Patricia Diaz

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Deep impact: sequencing embryo biopsy specimens at increasing depth by Spath, Katharina, Wells, Dagan

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Lactobacillus plantarum and Lactobacillus buchneri as Expression Systems: Evaluation of Different Origins of Replication for the Design of Suitable Shuttle Vectors by Spath, Katharina, Heinl, Stefan, Egger, Esther, Grabherr, Reingard

“…The objectives of this study were to establish transformation protocols for Lactobacillus plantarum CD033 and Lactobacillus buchneri CD034, two industrial…”
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FIRST REGISTERED PILOT TRIAL TO VALIDATE THE SAFETY AND EFFECTIVENESS OF MATERNAL SPINDLE TRANSFER TO OVERCOME INFERTILITY ASSOCIATED WITH POOR OOCYTE QUALITY by Costa-Borges, Nuno, Nikitos, Eros, Spath, Katharina, Rink, Klaus, Kostaras, Konstantinos, Zervomanolakis, Ioannis, Kontopoulos, George, Polyzos, Panagiotis, Grigorakis, Stylianos, Prokopakis, Thomas, Vasilopoulos, Yannis, Vlahos, Nikos, de Ziegler, Dominique, Wells, Dagan, Psathas, Panagiotis, Calderón, Gloria

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Preliminary results from the first registered pilot trial with maternal spindle transfer to overcome infertility by Costa-Borges, Nuno, Nikitos, Eros, Spath, Katharina, Wells, Dagan, Rink, Klaus, Vasilopoulos, Yannis, Zervomanolakis, Ioannis, Konstantinos, Dimitropoulos, Panagiotis, Polyzos, Grigorakis, Stylianos, Kontopoulos, George, Kostaras, Konstantinos, Psathas, Panagiotis S., Calderón, Gloria

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Sequence analysis and characterization of two cryptic plasmids derived from Lactobacillus buchneri CD034 by Heinl, Stefan, Spath, Katharina, Egger, Esther, Grabherr, Reingard

“…► We sequenced and characterized two novel plasmids from Lactobacillus buchneri. ► Both plasmids belong to rolling circle replicating plasmid families. ► Both…”
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Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential: e1005241 by Fragouli, Elpida, Spath, Katharina, Alfarawati, Samer, Kaper, Fiona, Craig, Andrew, Michel, Claude-Edouard, Kokocinski, Felix, Cohen, Jacques, Munne, Santiago, Wells, Dagan

“…Mitochondria play a vital role in embryo development. They are the principal site of energy production and have various other critical cellular functions…”
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