Electrospun curcumin-loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity

Novel fibrous materials from cellulose acetate (CA) and polyvinylpyrrolidone (PVP) containing curcumin (Curc) with original design were prepared by one-pot electrospinning or dual spinneret electrospinning. The electrospun materials were characterized by scanning electron microscopy (SEM), fluoresce...

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Bibliographic Details
Published in:	Materials Science & Engineering C Vol. 73; pp. 206 - 214
Main Authors:	Tsekova, Petya B., Spasova, Mariya G., Manolova, Nevena E., Markova, Nadya D., Rashkov, Iliya B.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-04-2017 Elsevier BV
Subjects:	Acetic acid Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial materials Architecture Bioactive compounds Biocompatibility Calorimetry Calorimetry, Differential Scanning Cellulose - analogs & derivatives Cellulose - chemistry Cellulose acetate Cellulose fibers Chemical compounds Contact angle Curcumin Curcumin - pharmacology Differential scanning calorimetry Drug Liberation Electron microscopy Electrospinning Fibers Fibrous materials Fluorescence Fluorescence microscopy Fourier transforms Heat measurement Infrared spectroscopy Kinetics Materials science Mats Microbial Sensitivity Tests Microscopy, Electron, Scanning Microscopy, Fluorescence Polymers Polyvinylpyrrolidone Povidone - chemistry Scanning electron microscopy Solutions Spectroscopy Spectroscopy, Fourier Transform Infrared Spectrum analysis Staphylococcus aureus - drug effects Time Factors Ultrasonic testing Ultraviolet spectroscopy Viscosity Water - chemistry Wound dressings Wounds X-Ray Diffraction Electrospinning Antibacterial activity Curcumin Polyvinylpyrrolidone Wound dressings Cellulose acetate
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Summary:	Novel fibrous materials from cellulose acetate (CA) and polyvinylpyrrolidone (PVP) containing curcumin (Curc) with original design were prepared by one-pot electrospinning or dual spinneret electrospinning. The electrospun materials were characterized by scanning electron microscopy (SEM), fluorescence microscopy, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV–Vis), differential scanning calorimetry (DSC), water contact angle measurements, and microbiological tests. It was found that the incorporation of Curc into the CA and PVP solutions resulted in an increase of the solution viscosity and obtaining fibers with larger diameters (ca. 1.5μm) compared to the neat CA (ca. 800nm) and PVP fibers (ca. 500nm). The incorporation of PVP resulted in increased hydrophilicity of the fibers and in faster Curc release. Curc was found in the amorphous state in the Curc-containing fibers and these mats exhibited antibacterial activity against Staphylococcus aureus (S. aureus). The results suggest that, due to their complex architecture, the obtained new antibacterial materials are suitable for wound dressing applications, which necessitate diverse release behaviors of the bioactive compound. [Display omitted] •Novel curcumin-loaded materials based on cellulose acetate and polyvinylpyrrolidone were prepared by electrospinning.•Using one-pot or dual spinneret electrospinning enabled modulating drug release.•The incorporation of polyvinylpyrrolidone resulted in faster curcumin release.•The curcumin-containing mats exhibited antibacterial activity thus rendering them suitable for wound dressing applications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0928-4931 1873-0191
DOI:	10.1016/j.msec.2016.12.086