Search Results - "Sparling, David"

Diabetes Technology Use for Management of Type 1 Diabetes Is Associated With Fewer Adverse COVID-19 Outcomes: Findings From the T1D Exchange COVID-19 Surveillance Registry by Noor, Nudrat, Ebekozien, Osagie, Levin, Laura, Stone, Sheri, Sparling, David P., Rapaport, Robert, Maahs, David M.

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Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study by Shah, Viral N, DuBose, Stephanie N, Li, Zoey, Beck, Roy W, Peters, Anne L, Weinstock, Ruth S, Kruger, Davida, Tansey, Michael, Sparling, David, Woerner, Stephanie, Vendrame, Francesco, Bergenstal, Richard, Tamborlane, William V, Watson, Sara E, Sherr, Jennifer

“…Abstract Context Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. Although data on glycemic profiles of…”
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Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma by Tryggestad, Jeanie B., Teague, April M., Sparling, David P., Jiang, Shaoning, Chernausek, Steven D.

“…Objective This study aimed to investigate cellular sources of microRNAs (miRNA) within adipose tissue and the impact of obesity on miRNA expression, as well as…”
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mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2 by Kim, KyeongJin, Qiang, Li, Hayden, Matthew S., Sparling, David P., Purcell, Nicole H., Pajvani, Utpal B.

“…Mechanistic target of rapamycin complex 1 (mTORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regulator of…”
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Real-Time Continuous Glucose Monitoring Reduced Costly Diabetes-Related Events in Adolescents and Young Adults despite Lack of Short-Term Reduction in Hemoglobin A1c by Beck, Joni K., Allen, Rebecca A., Jeter, Kathryn M., Fisher, Rachel S., Dattilo, Taylor M., Traino, Katherine A., Anderson, Michael, Cutler, James, Sparling, David P.

“…Real-time continuous glucose monitoring (rtCGM) can directly improve patient outcomes, including decreased health care system utilization and associated costs…”
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GLUT4 Enhancer Factor (GEF) Interacts with MEF2A and HDAC5 to Regulate the GLUT4 Promoter in Adipocytes by Sparling, David P., Griesel, Beth A., Weems, Juston, Olson, Ann Louise

“…The insulin-responsive glucose transporter, GLUT4, is regulated in various physiologic states at the transcriptional level. When expressed in transgenic mice,…”
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Farm Support Payments and Risk Balancing: Implications for Financial Riskiness of Canadian Farms by Uzea, Nicoleta, Poon, Kenneth, Sparling, David, Weersink, Alfons

“…Risk balancing refers to the balancing of business risk (BR) and financial risk (FR) by firms through their investment and borrowing decisions. Assuming the…”
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Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation by Sparling, David P., McCullough, Nile, Pajvani, Utpal, Humphrey, Mary Beth

“…Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration…”
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Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase by Holmes, Burton F, Sparling, David P, Olson, Ann Louise, Winder, William W, Dohm, G Lynis

“…As the primary glucose transporter in skeletal muscle, GLUT4 is an important factor in the regulation of blood glucose. We previously reported that stimulation…”
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Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity by Sparling, David P, Yu, Junjie, Kim, KyeongJin, Zhu, Changyu, Brachs, Sebastian, Birkenfeld, Andreas L, Pajvani, Utpal B

“…Abstract Objective As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D)…”
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Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase by Sparling, David P, Fabian, Kendra, Harik, Lara, Jobanputra, Vaidehi, Anyane-Yeboa, Kwame, Oberfield, Sharon E, Fennoy, Ilene

“…Thyroid dyshormonogenesis continues to be a significant cause of congenital hypothyroidism. Over time, forms of thyroid dyshormonogenesis can result in goiter,…”
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Regulation and the financial performance of Canadian agribusinesses by Schaufele, Brandon, Sparling, David

“…Purpose - The purpose of this paper is to investigate the relationships between regulatory changes, returns on equity and stock market valuations for Canadian…”
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Hyperphosphorylation of MEF2A in primary adipocytes correlates with downregulation of human GLUT4 gene promoter activity by Sparling, David P, Griesel, Beth A, Olson, Ann Louise

“…GLUT4 promoter activity is regulated by hormonal, metabolic, and tissue-specific controls. This complicates the study of GLUT4 gene transcription, as no cell…”
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Adipocyte Gamma-Secretase Inhibition May Alter IL-6 Expression and Trafficking by SPARLING, DAVID, MCCULLOUGH, NILE

“…Adipocyte-mediated inflammatory signaling has been proposed to alter adipose physiology in obesity. Activation of adipocytes can increase secretion of…”
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1633-P: CRISPLD2 Is Secreted by Adipocytes and Can Reduce Adipocyte Size by Griesel, Beth A, Olson, Ann L, Sparling, David

“…Obesity is a primary risk factor for type 2 diabetes, with excess adiposity leading to worsening insulin resistance and an increase in adipose tissue…”
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Novel Role for an HPt Domain in Stabilizing the Phosphorylated State of a Response Regulator Domain by Janiak-Spens, Fabiola, Sparling, David P., West, Ann H.

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Risking Market Integration without Regulatory Integration: The Case of NAFTA and BSE by Sparling, David H., Caswell, Julie A.

“…Under the North American Free Trade Agreement (NAFTA), there has been a dramatic increase in the integration of markets for live cattle and beef products in…”
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111-OR: MODY3 Diagnosis from Deidentified Pancreatic Tissue Leads to Variant Identification in Living Relatives by SPARLING, DAVID, HALIYUR, RACHANA, LINDNER, JILL, WEBER, LINDA, RAMIREZ, ANDREA, BRISSOVA, MARCELA, POWERS, ALVIN C.

“…As part of studies to understand human pancreatic islet pathophysiology in type 1 diabetes (T1D), we discovered normal β cell mass in a 33-year-old deceased…”
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Weight loss resulted in increased expression of the anti-inflammatory protein, CRISPLD2, in mouse adipose tissue by Jackson, Robert M., Griesel, Beth A., Short, Kevin R., Sparling, David, Freeman, Willard M., Olson, Ann Louise

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Degradation of the Nuclear Matrix Is a Common Element during Radiation-Induced Apoptosis and Necrosis by Dynlacht, Joseph R., Earles, Marvin, Henthorn, Jim, Roberts, Zachary V., Howard, Eric W., Seno, Joshua D., Sparling, David, Story, Michael D.

“…Human promyelocytic leukemia (HL60) cells were irradiated with 10 or 50 Gy of X rays and studied for up to 72 h postirradiation to determine the mode of death…”
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