Search Results - "Sparks, Thomas C"

IRAC: Mode of action classification and insecticide resistance management by Sparks, Thomas C., Nauen, Ralf

“…•Insecticide resistance is expanding – >580 species resistant to >1 insecticides.•IRAC – promotes development and use of standardized bioassays for resistance…”
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Perspectives on the agrochemical industry and agrochemical discovery by Sparks, Thomas C, Lorsbach, Beth A

“…Agrochemicals have been critical to the production of food and fiber, as well as the control of vectors of disease. The need for the discovery and development…”
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Insecticide resistance management and industry: the origins and evolution of the Insecticide Resistance Action Committee (IRAC) and the mode of action classification scheme by Sparks, Thomas C, Storer, Nicholas, Porter, Alan, Slater, Russell, Nauen, Ralf

“…Insecticide resistance is a long‐standing problem affecting the efficacy and utility of crop protection compounds. Insecticide resistance also impacts the…”
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Natural product derived insecticides: discovery and development of spinetoram by Galm, Ute, Sparks, Thomas C

“…This review highlights the importance of natural product research and industrial microbiology for product development in the agricultural industry, based on…”
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The new age of insecticide discovery-the crop protection industry and the impact of natural products by Sparks, Thomas C., Wessels, Frank J., Lorsbach, Beth A., Nugent, Benjamin M., Watson, Gerald B.

“…Improvements in food production and disease vector control, to feed and protect an expanding global population, require new options and approaches for insect…”
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Sulfoxaflor and the sulfoximine insecticides: Chemistry, mode of action and basis for efficacy on resistant insects by Sparks, Thomas C., Watson, Gerald B., Loso, Michael R., Geng, Chaoxian, Babcock, Jon M., Thomas, James D.

“…•Sulfoxaflor (SFX) is a sulfoximine insecticide with a distinct mode of action (MoA).•SFX is not a neonicotinoid – different chemistry and structure activity…”
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Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster by Perry, Trent, Chen, Wei, Ghazali, Razi, Yang, Ying Ting, Christesen, Danielle, Martelli, Felipe, Lumb, Chris, Bao Luong, Hang Ngoc, Mitchell, Judith, Holien, Jessica K., Parker, Michael W., Sparks, Thomas C., Batterham, Philip

“…Insecticides remain valuable tools for the control of insect pests that significantly impact human health and agriculture. A deeper understanding of…”
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Discovery and Characterization of Sulfoxaflor, a Novel Insecticide Targeting Sap-Feeding Pests by Zhu, Yuanming, Loso, Michael R, Watson, Gerald. B, Sparks, Thomas C, Rogers, Richard B, Huang, Jim X, Gerwick, B. Clifford, Babcock, Jonathan M, Kelley, Donald, Hegde, Vidyadhar B, Nugent, Benjamin M, Renga, James M, Denholm, Ian, Gorman, Kevin, DeBoer, Gerrit J, Hasler, James, Meade, Thomas, Thomas, James D

“…The discovery of sulfoxaflor [N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene] cyanamide] resulted from an investigation of the…”
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Impact of the nicotinic acetylcholine receptor mutation R81T on the response of European Myzus persicae populations to imidacloprid and sulfoxaflor in laboratory and in the field by Mezei, Imre, Valverde-Garcia, Pablo, Siebert, Melissa W., Gomez, Luis E., Torne, Maria, Watson, Gerald B., Raquel, Abad M., Fereres, Alberto, Sparks, Thomas C.

“…Sulfoxaflor (Isoclast™ active) is a sulfoximine insecticide that is active on a broad range of sap-feeding insects, including species that exhibit reduced…”
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Novel nicotinic action of the sulfoximine insecticide sulfoxaflor by Watson, Gerald B., Loso, Michael R., Babcock, Jonathan M., Hasler, James M., Letherer, Theodore J., Young, Cathy D., Zhu, Yuanming, Casida, John E., Sparks, Thomas C.

“…The novel sulfoximine insecticide sulfoxaflor is as potent or more effective than the neonicotinoids for toxicity to green peach aphids (GPA, Myzus persicae)…”
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Biological characterization of sulfoxaflor, a novel insecticide by Babcock, Jonathan M, Gerwick, Clifford B, Huang, Jim X, Loso, Michael R, Nakamura, Genta, Nolting, Steven P, Rogers, Richard B, Sparks, Thomas C, Thomas, James, Watson, Gerald B, Zhu, Yuanming

“…BACKGROUND: The commercialization of new insecticides is important for ensuring that multiple effective product choices are available. In particular, new…”
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Characterization of a nicotinic acetylcholine receptor binding site for sulfoxaflor, a new sulfoximine insecticide for the control of sap-feeding insect pests by Watson, Gerald B., Olson, Monica B., Beavers, Kenneth W., Loso, Michael R., Sparks, Thomas C.

“…Sulfoxaflor (SFX, Isoclast™ Active) is a recently developed sulfoximine insecticide that is highly effective against sap-feeding insect pests. SFX has been…”
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ACS Agrochemical Division (AGRO): Fifty Years as a Catalyst for Innovation by Sparks, Thomas C.

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Insecticide discovery: An evaluation and analysis by Sparks, Thomas C.

“…[Display omitted] •The number of US & EU R&D-based companies involved in pesticide discovery is declining.•The cost of discovering and developing a new…”
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Insecticide mixtures-uses, benefits and considerations by Sparks, Thomas C

“…Insecticides remain an important tool for the control of many insect pests. There has long been an interest in insecticide mixtures (in-can and tank-mix) as a…”
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Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery by Sparks, Thomas C, Duke, Stephen O

“…Natural products (NPs) have a long history as sources of compounds for crop protection. Perhaps a more important role for NPs has been as models and…”
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Differential metabolism of sulfoximine and neonicotinoid insecticides by Drosophila melanogaster monooxygenase CYP6G1 by Sparks, Thomas C, DeBoer, Gerrit J, Wang, Nick X, Hasler, James M, Loso, Michael R, Watson, Gerald B

“…[Display omitted] ► The monooxygenase CYP6G1 was cloned and expressed in D.mel-2 cells. ► Sulfoxaflor (SFX) and its chloropyridine-analog were not metabolized…”
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Impact of natural products on discovery of, and innovation in, crop protection compounds by Sparks, Thomas C, Bryant, Robert J

“…Natural products (NPs) have long been an important source of, and inspiration for, developing novel compounds to control weeds, pathogens and insect pests. In…”
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Natural products for pest control: an analysis of their role, value and future by Gerwick, B Clifford, Sparks, Thomas C

“…Natural products (NPs) have long been used as pesticides and have broadly served as a source of inspiration for a great many commercial synthetic organic…”
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Effects of mutations in Drosophila nicotinic acetylcholine receptor subunits on sensitivity to insecticides targeting nicotinic acetylcholine receptors by Perry, Trent, Chan, Janice Q, Batterham, Phil, Watson, Gerald B, Geng, Chaoxian, Sparks, Thomas C

“…[Display omitted] ► Dα1 nAChR Drosophila mutants were resistant to neonicotinoids, excluding dinotefuran. ► Dβ2 and double nAChR mutant strains were resistant…”
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