Search Results - "Sparks, Justin L."

RNase H2-Initiated Ribonucleotide Excision Repair by Sparks, Justin L., Chon, Hyongi, Cerritelli, Susana M., Kunkel, Thomas A., Johansson, Erik, Crouch, Robert J., Burgers, Peter M.

“…Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at frequencies of about 2 per kb, which makes them by far the most abundant form…”
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Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts by Larsen, Nicolai B., Gao, Alan O., Sparks, Justin L., Gallina, Irene, Wu, R. Alex, Mann, Matthias, Räschle, Markus, Walter, Johannes C., Duxin, Julien P.

“…DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the…”
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Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides by Sparks, Justin L, Burgers, Peter M

“…Genomic ribonucleotides incorporated during DNA replication are commonly repaired by RNase H2‐dependent ribonucleotide excision repair (RER). When RNase H2 is…”
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TRAIP is a master regulator of DNA interstrand crosslink repair by Wu, R. Alex, Semlow, Daniel R., Kamimae-Lanning, Ashley N., Kochenova, Olga V., Chistol, Gheorghe, Hodskinson, Michael R., Amunugama, Ravindra, Sparks, Justin L., Wang, Meng, Deng, Lin, Mimoso, Claudia A., Low, Emily, Patel, Ketan J., Walter, Johannes C.

“…Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway has substantial implications for the fidelity of genome maintenance…”
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RNase H2 roles in genome integrity revealed by unlinking its activities by Chon, Hyongi, Sparks, Justin L., Rychlik, Monika, Nowotny, Marcin, Burgers, Peter M., Crouch, Robert J., Cerritelli, Susana M.

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The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair by Sparks, Justin L., Chistol, Gheorghe, Gao, Alan O., Räschle, Markus, Larsen, Nicolai B., Mann, Matthias, Duxin, Julien P., Walter, Johannes C.

“…Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten genome integrity. Using Xenopus egg extracts, we previously showed…”
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The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair by Yaneva, Denitsa, Sparks, Justin L., Donsbach, Maximilian, Zhao, Shubo, Weickert, Pedro, Bezalel-Buch, Rachel, Stingele, Julian, Walter, Johannes C.

“…Endogenous and exogenous agents generate DNA-protein crosslinks (DPCs), whose replication-dependent degradation by the SPRTN protease suppresses aging and…”
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Yeast Exonuclease 5 Is Essential for Mitochondrial Genome Maintenance by Burgers, Peter M., Stith, Carrie M., Yoder, Bonita L., Sparks, Justin L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RNase H2 roles in genome integrity revealed by unlinking its activities by Chon, Hyongi, Sparks, Justin L, Rychlik, Monika, Nowotny, Marcin, Burgers, Peter M, Crouch, Robert J, Cerritelli, Susana M

“…Ribonuclease H2 (RNase H2) protects genome integrity by its dual roles of resolving transcription-related R-loops and ribonucleotides incorporated in DNA…”
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The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stability by Sparks, Justin L., Gerik, Kimberly J., Stith, Carrie M., Yoder, Bonita L., Burgers, Peter M.

“…•Exo5 is an understudied 5′-exonuclease that is downregulated in several cancers.•Fission yeast Exo5 is a good model system for the human enzyme.•Fission yeast…”
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Human Exonuclease 5 Is a Novel Sliding Exonuclease Required for Genome Stability by Sparks, Justin L., Kumar, Rakesh, Singh, Mayank, Wold, Marc S., Pandita, Tej K., Burgers, Peter M.

“…Previously, we characterized Saccharomyces cerevisiae exonuclease 5 (EXO5), which is required for mitochondrial genome maintenance. Here, we identify the human…”
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The FANCJ Helicase Unfolds DNA-Protein Cross-Links to Promote Their Repair by Yaneva, Denitsa, Sparks, Justin L., Donsbach, Maximilian, Zhao, Shubo, Weickert, Pedro, Bezalel-Buch, Rachel, Stingele, Julian, Walter, Johannes C.

“…Endogenous and exogenous agents generate DNA-protein cross-links (DPCs), whose replication-dependent degradation by the SPRTN protease suppresses aging and…”
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TRAIP is a master regulator of DNA interstrand cross-link repair by Wu, R. Alex, Semlow, Daniel R., Kamimae-Lanning, Ashley N., Kochenova, Olga V., Chistol, Gheorghe, Hodskinson, Michael R., Amunugama, Ravindra, Sparks, Justin L., Wang, Meng, Deng, Lin, Mimoso, Claudia A., Low, Emily, Patel, Ketan J., Walter, Johannes C.

“…Cells often utilize multiple pathways to repair the same DNA lesion, and pathway choice has profound implications for the fidelity of genome maintenance. DNA…”
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