Search Results - "Sparkman, Nathan"

Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior by Burton, Michael D, Sparkman, Nathan L, Johnson, Rodney W

“…Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior. Therefore, this…”
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Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress by Sparkman, Nathan L, Johnson, Rodney W

“…The aging brain is characterized by a shift from the homeostatic balance of inflammatory mediators to a proinflammatory state. This increase in…”
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Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system by Chen, Jing, Buchanan, Jessica B, Sparkman, Nathan L, Godbout, Jonathan P, Freund, Gregory G, Johnson, Rodney W

“…Abstract Acute cognitive disorders are common in elderly patients with peripheral infections but it is not clear why. Here, we injected old and young mice with…”
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Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell Layers by Sparkman, Nathan L, Buchanan, Jessica B, Heyen, Jonathan R. R, Chen, Jing, Beverly, James L, Johnson, Rodney W

“…Proinflammatory cytokines inhibit learning and memory but the significance of interleukin-6 (IL-6) in acute cognitive deficits induced by the peripheral innate…”
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Aging sensitizes male mice to cognitive dysfunction induced by central HIV-1 gp120 by Sparkman, Nathan L., Buchanan, Jessica B., Dos Santos, Natalia L., Johnson, Rodney W., Burton, Michael D.

“…Although highly active antiretroviral therapy has led to improved prognosis and alleviation of some HIV-related disease complications, it has not provided…”
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A drug–drug conditioning paradigm reveals multiple antipsychotic–nicotine interactions by Feng, Min, Sparkman, Nathan L, Sui, Nan, Li, Ming

“…Clinical studies indicate a reciprocal impact between nicotine use and antipsychotic medications in patients with schizophrenia. The present study used a…”
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Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide by Richwine, Amy F, Sparkman, Nathan L, Dilger, Ryan N, Buchanan, Jessica B, Johnson, Rodney W

“…Abstract Interleukin (IL)-10 is important for regulating inflammation but whether it protects against infection-related deficits in cognitive function is…”
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A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus by Buchanan, Jessica B, Sparkman, Nathan L, Johnson, Rodney W

“…Methamphetamine (MA) use is associated with activation of microglia and, at high doses, can induce neurotoxicity. Given the changes in the neuroinflammatory…”
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Drug–drug conditioning between citalopram and haloperidol or olanzapine in a conditioned avoidance response model: implications for polypharmacy in schizophrenia by Sparkman, Nathan L, Li, Ming

“…Patients with schizophrenia often have anxiety and depression, and thus are treated with multiple psychotherapeutic medications. This practice of polypharmacy…”
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Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice by Sparkman, Nathan L., Martin, Luci A., Calvert, William S., Boehm, Gary W.

“…Several studies have shown that systemic lipopolysaccharide (LPS) or interleukin-1β (IL-1β) may affect performance in various learning tasks, including the…”
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Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System by GODBOUT, Jonathan P, MOREAU, Maïté, LESTAGE, Jacques, JING CHEN, SPARKMAN, Nathan L, O'CONNOR, Jason, CASTANON, Nathalie, KELLEY, Keith W, DANTZER, Robert, JOHNSON, Rodney W

“…Exposure to peripheral infections may be permissive to cognitive and behavioral complications in the elderly. We have reported that peripheral stimulation of…”
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Peripheral lipopolysaccharide administration impairs two-way active avoidance conditioning in C57BL/6J mice by Sparkman, Nathan L., Kohman, Rachel A., Garcia, Anya K., Boehm, Gary W.

“…Peripheral administration of lipopolysaccharide (LPS) or interleukin-1 (IL-1) may lead to alterations of CNS function and behavioral changes designated…”
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Bacterial endotoxin-induced behavioral alterations in two variations of the Morris water maze by Sparkman, Nathan L., Kohman, Rachel A., Scott, Vincent J., Boehm, Gary W.

“…Several studies report that lipopolysaccharide (LPS) or interleukin-1β (IL-1β) may affect behavior in a variety of learning tasks, including the Morris water…”
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Neonatal endotoxin exposure impairs avoidance learning and attenuates endotoxin-induced sickness behavior and central IL-1β gene transcription in adulthood by Kohman, Rachel A., Tarr, Andrew J., Sparkman, Nathan L., Bogale, Tiroyaone M.H., Boehm, Gary W.

“…Infection during infancy, a time of critical neural development, may have long-term implications. Infection or exposure to an immune stimulus such as…”
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Neonatal endotoxin exposure impairs avoidance learning and attenuates endotoxin-induced sickness behavior and central IL-1beta gene transcription in adulthood by Kohman, Rachel A, Tarr, Andrew J, Sparkman, Nathan L, Bogale, Tiroyaone M H, Boehm, Gary W

“…Infection during infancy, a time of critical neural development, may have long-term implications. Infection or exposure to an immune stimulus such as…”
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Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system by Godbout, Jonathan P., Moreau, Maite, Lestage, Jacques, Chen, Jing, Sparkman, Nathan L., Castanon, Nathalie, Kelley, Keith W., Dantzer, Robert, Johnson, Rodney W.

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Peripheral immune activation leads to increased cytokine expression in the hippocampus and cognitive deficits in aged mice by Sparkman, Nathan L., Chen, Jing, Buchanan, Jessie B., Johnson, Rodney W.

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Peripheral immune activation, cytokines, and behavior: Effects of endotoxin exposure on two -way active avoidance conditioning by Sparkman, Nathan L

“…Peripheral administration of lipopolysaccharide (LPS) or interleukin-1 (IL-1) may lead to alterations of CNS function and behavioral changes designated…”
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Interval timing in rats: tracking unsignaled changes in the fixed interval schedule requirement by Higa, Jennifer J., Moreno, Sara, Sparkman, Nathan

“…The present experiment examined interval timing in rats under dynamic conditions. A session began with FI60 s intervals, changed to a FI20 s, FI30 s, or FI40 s…”
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