Search Results - "Sparkes, Dominic"

Progressive skin ulceration in a febrile returning traveller by Sparkes, Dominic, Leong, Clare, Wilson, Michael, Carmichael, Andrew

“…Two weeks prior to admission, while in Cape Verde, a 66-year-old man developed a fever and a necrotic ulcer on his right leg following an insect bite. He was…”
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A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities by Sridhar, Sushmita, Forrest, Sally, Kean, Iain, Young, Jamie, Bartholdson Scott, Josefin, Maes, Mailis, Pereira-Dias, Joana, Parmar, Surendra, Routledge, Matthew, Sparkes, Dominic, Rivett, Lucy, Dougan, Gordon, Weekes, Michael, Curran, Martin, Goodfellow, Ian, Baker, Stephen

“…The COVID-19 pandemic is expanding at an unprecedented rate. As a result, diagnostic services are stretched to their limit, and there is a clear need for the…”
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Specificity and positive predictive value of SARS-CoV-2 nucleic acid amplification testing in a low-prevalence setting by Skittrall, Jordan P., Wilson, Michael, Smielewska, Anna A., Parmar, Surendra, Fortune, Mary D., Sparkes, Dominic, Curran, Martin D., Zhang, Hongyi, Jalal, Hamid

“…When the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is low, many positive test results are false positives. Confirmatory…”
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Effectiveness of BNT162b2 mRNA vaccine third doses and previous infection in protecting against SARS-CoV-2 infections during the Delta and Omicron variant waves; the UK SIREN cohort study September 2021 to February 2022 by Hall, Victoria J, Insalata, Ferdinando, Foulkes, Sarah, Kirwan, Peter, Sparkes, Dominic, Atti, Ana, Cole, Michelle, de Lacy, Elen, Price, Lesley, Corrigan, Diane, Brown, Colin S, Islam, Jasmin, Charlett, Andre, Hopkins, Susan

“…Third doses of COVID-19 vaccines were widely deployed following the primary vaccine course waning and the emergence of the Omicron-variant. We investigated…”
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Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections by Illingworth, Christopher Jr, Hamilton, William L, Warne, Ben, Routledge, Matthew, Popay, Ashley, Jackson, Chris, Fieldman, Tom, Meredith, Luke W, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Caller, Laura G, Caddy, Sarah L, Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin D, Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K, Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Ferris, Mark, Gkrania-Klotsas, Effrossyni, Brown, Nicholas M, Weekes, Michael P, Baker, Stephen, Peacock, Sharon J, Goodfellow, Ian G, Gouliouris, Theodore, de Angelis, Daniela, Török, M Estée

“…SARS-CoV-2 is notable both for its rapid spread, and for the heterogeneity of its patterns of transmission, with multiple published incidences of…”
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Protection of vaccine boosters and prior infection against mild/asymptomatic and moderate COVID-19 infection in the UK SIREN healthcare worker cohort: October 2023 to March 2024 by Kirwan, Peter D., Foulkes, Sarah, Munro, Katie, Sparkes, Dominic, Singh, Jasleen, Henry, Amanda, Dunne, Angela, Timeyin, Jean, Russell, Sophie, Khawam, Jameel, Blick, Debbie, Otter, Ashley D., Hettiarachchi, Nipunadi, Cairns, Michelle D., Jackson, Christopher H., Seaman, Shaun, Brown, Colin S., Atti, Ana, Islam, Jasmin, Charlett, Andre, De Angelis, Daniela, Presanis, Anne M., Hall, Victoria J., Hopkins, Susan

“…Bivalent original/BA.4–5 and monovalent XBB.1.5 mRNA boosters were offered to UK healthcare workers (HCWs) in the autumn of 2023. We aimed to estimate booster…”
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Streamlining SARS-CoV-2 confirmatory testing to reduce false positive results by Wilson, Michael J., Sparkes, Dominic, Myers, Chloe, Smielewska, Anna A., Husain, Mir Mubariz, Smith, Christopher, Rolfe, Kathryn J., Zhang, Hongyi, Jalal, Hamid

“…•False positive SARS-CoV-2 results occur which can lead to harm.•Confirmatory testing is critical to reduce false positive results.•Confirmatory testing has a…”
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Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19 by Jones, Nick K, Rivett, Lucy, Sparkes, Dominic, Forrest, Sally, Sridhar, Sushmita, Young, Jamie, Pereira-Dias, Joana, Cormie, Claire, Gill, Harmeet, Reynolds, Nicola, Wantoch, Michelle, Routledge, Matthew, Warne, Ben, Levy, Jack, Córdova Jiménez, William David, Samad, Fathima Nisha Begum, McNicholas, Chris, Ferris, Mark, Gray, Jane, Gill, Michael, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Bradley, John R, Hannon, Gregory J, Goodfellow, Ian G, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Wright, Giles, Matheson, Nicholas J, Baker, Stephen, Weekes, Michael P

“…Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for…”
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Early Warning Surveillance for SARS-CoV-2 Omicron Variants, United Kingdom, November 2021-September 2022 by Foulkes, Sarah, Monk, Edward J M, Sparkes, Dominic, Hettiarachchi, Nipunadi, Milligan, Iain D, Munro, Katie, Taylor-Kerr, Andrew, Platt, Naomi, Howells, Anna, Kyaw, Jerry Ye Aung, Adaji, Enemona, Gallagher, Eileen, Khawam, Jameel, Wellington, Edgar, Price, Lesley, Crossman, David, Norman, Chris, de Lacy, Elen, Cromey, Lisa, Corrigan, Diane, Lackenby, Angie, Barbero, Paola, Elegunde, Busayo, Zambon, Maria, Chand, Meera A, Brown, Colin S, Islam, Jasmin, Atti, Ana, Hopkins, Susan, Hall, Victoria J, Cole, Michelle J

“…Since June 2020, the SARS-CoV-2 Immunity and Reinfection Evaluation (SIREN) study has conducted routine PCR testing in UK healthcare workers and sequenced…”
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A2B-COVID: A Tool for Rapidly Evaluating Potential SARS-CoV-2 Transmission Events by Illingworth, Christopher J R, Hamilton, William L, Jackson, Christopher, Warne, Ben, Popay, Ashley, Meredith, Luke, Hosmillo, Myra, Jahun, Aminu, Fieldman, Tom, Routledge, Matthew, Houldcroft, Charlotte J, Caller, Laura, Caddy, Sarah, Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin, Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K, Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Gkrania-Klotsas, Effrossyni, Brown, Nicholas M, Weekes, Michael P, Baker, Stephen, Peacock, Sharon J, Gouliouris, Theodore, Goodfellow, Ian, Angelis, Daniela De, Török, M Estée

“…Abstract Identifying linked cases of infection is a critical component of the public health response to viral infectious diseases. In a clinical context, there…”
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A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital by Cooper, Daniel J, Lear, Sara, Watson, Laura, Shaw, Ashley, Ferris, Mark, Doffinger, Rainer, Bousfield, Rachel, Sharrocks, Katherine, Weekes, Michael P., Warne, Ben, Sparkes, Dominic, Jones, Nick K, Rivett, Lucy, Routledge, Matthew, Chaudhry, Afzal, Dempsey, Katherine, Matson, Montgomery, Lakha, Adil, Gathercole, George, O'Connor, Olivia, Wilson, Emily, Shahzad, Orthi, Toms, Kieran, Thompson, Rachel, Halsall, Ian, Halsall, David, Houghton, Sally, Papadia, Sofia, Kingston, Nathalie, Stirrups, Kathleen E, Graves, Barbara, Townsend, Paul, Walker, Neil, Stark, Hannah, De Angelis, Daniela, Seaman, Shaun, Dougan, Gordon, Bradley, John R, Török, M. Estée, Goodfellow, Ian, Baker, Stephen

“…•The risk of SARS-CoV-2 infection in healthcare workers is highly heterogeneous•The risk of SARS-CoV-2 is significantly higher in BAME healthcare…”
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Applying prospective genomic surveillance to support investigation of hospital-onset COVID-19 by Hamilton, William L, Fieldman, Tom, Jahun, Aminu, Warne, Ben, Illingworth, Christopher J R, Jackson, Chris, Blane, Beth, Moore, Elinor, Weekes, Michael P, Peacock, Sharon J, De Angelis, Daniela, Goodfellow, Ian, Gouliouris, Theodore, Török, M Estée, Curran, Martin D, Parmar, Surendra, Hosmillo, Myra, Chaudhry, Yasmin, Pinckert, Malte L, Georgana, Iliana, Izuagbe, Rhys, Ferris, Mark, Workman, Chris, Jones, Nick K, Rivett, Lucy, Sparkes, Dominic, Routledge, Matthew, Enoch, David, Whitehorn, James, Moody, Christine, Brennan, Liam, Smith, Richard, Tsui, Rachel, Bousfield, Rachel, Pocock, Joanna, Toleman, Michelle, Payne, Helen, Coscione, Suny, Myers, Chloe, Sharrocks, Katherine, Ravji, Pooja, Leong, Clare, Ramsay, Isobel

“…[...]changes in SARS-CoV-2 diagnostic methods resulted in technical difficulties in obtaining sufficient good-quality genetic material for sequencing. [...]the…”
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Adapting COVID-19 research infrastructure to capture influenza and respiratory syncytial virus alongside SARS-CoV-2 in UK healthcare workers winter 2022/23 and beyond: protocol for a pragmatic sub-study by Broad, Jonathan, Sparkes, Dominic, Platt, Naomi, Howells, Anna, Foulkes, Sarah, Khawam, Jameel, Cole, Michelle, Andrews, Nick, Watson, Conall, Hopkins, Susan, Hall, Victoria

“…Introduction During the COVID-19 pandemic, extensive research was conducted on SARS-CoV-2; however, important questions about other respiratory pathogens…”
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Adapting COVID-19 research infrastructure to capture influenza and respiratory syncytial virus alongside SARS-CoV-2 in UK healthcare workers winter 2022/23 and beyond: protocol for a pragmatic sub-study by Broad, Jonathan, Sparkes, Dominic, Platt, Naomi, Howells, Anna, Foulkes, Sarah, Khawam, Jameel, Cole, Michelle, Andrews, Nick, Watson, Conall, Hopkins, Susan, Hall, Victoria

“…Introduction During the COVID-19 pandemic, extensive research was conducted on SARS-CoV-2; however, important questions about other respiratory pathogens…”
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Adapting COVID-19 research infrastructure to capture influenza and respiratory syncytial virus alongside SARS-CoV-2 in UK healthcare workers winter 2022/23 and beyond: protocol for a pragmatic sub-study by Broad, Jonathan, Sparkes, Dominic, Platt, Naomi, Howells, Anna, Foulkes, Sarah, Khawam, Jameel, Cole, Michelle, Andrews, Nick, Watson, Conall, Hopkins, Susan, Hall, Victoria

“…Introduction During the COVID-19 pandemic, extensive research was conducted on SARS-CoV-2; however, important questions about other respiratory pathogens…”
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Rebooting medical education with virtual grand rounds during the COVID-19 pandemic by Sparkes, Dominic, Leong, Clare, Sharrocks, Katherine, Wilson, Michael, Moore, Elinor, Matheson, Nicholas J

“…Social distancing during the coronavirus disease 2019 (COVID-19) pandemic has necessitated drastic changes in the practice of hospital medicine, including the…”
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Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study by Collier, Dami A., Assennato, Sonny M., Warne, Ben, Sithole, Nyarie, Sharrocks, Katherine, Ritchie, Allyson, Ravji, Pooja, Routledge, Matthew, Sparkes, Dominic, Skittrall, Jordan, Smielewska, Anna, Ramsey, Isobel, Goel, Neha, Curran, Martin, Enoch, David, Tassell, Rhys, Lineham, Michelle, Vaghela, Devan, Leong, Clare, Mok, Hoi Ping, Bradley, John, Smith, Kenneth G.C., Mendoza, Vivienne, Demiris, Nikos, Besser, Martin, Dougan, Gordon, Lehner, Paul J., Siedner, Mark J., Zhang, Hongyi, Waddington, Claire S., Lee, Helen, Gupta, Ravindra K., Baker, Stephen, Bradley, John, Dougan, Gordon, Goodfellow, Ian, Gupta, Ravindra K., Lehner, Paul J., Lyons, Paul, Matheson, Nicholas J., Smith, Kenneth G.C., Toshner, Mark, Weekes, Michael P., Brown, Nick, Curran, Martin, Palmar, Surendra, Zhang, Hongyi, Enoch, David, Chapman, Daniel, Shaw, Ashley, Mendoza, Vivien, Jose, Sherly, Bermperi, Areti, Zerrudo, Julie Ann, Kourampa, Evgenia, Saunders, Caroline, de Jesus, Ranalie, Domingo, Jason, Pasquale, Ciro, Vergese, Bensi, Vargas, Phoebe, Fabiculana, Marivic, Perales, Marlyn, Skells, Richard, Mynott, Lee, Blake, Elizabeth, Bates, Amy, Vallier, Anne-laure, Williams, Alexandra, Phillips, David, Chiu, Edmund, Overhill, Alex, Ramenante, Nicola, Sipple, Jamal, Frost, Steven, Knock, Helena, Hardy, Richard, Foster, Emily, Davidson, Fiona, Rundell, Viona, Bundi, Purity, Abeseabe, Richmond, Clark, Sarah, Vicente, Isabel

“…There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid…”
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African sleeping sickness by Hedley, Lucy, Fink, Douglas, Sparkes, Dominic, Chiodini, Peter L

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Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohortResearch in context by Peter D. Kirwan, Victoria J. Hall, Sarah Foulkes, Ashley D. Otter, Katie Munro, Dominic Sparkes, Anna Howells, Naomi Platt, Jonathan Broad, David Crossman, Chris Norman, Diane Corrigan, Christopher H. Jackson, Michelle Cole, Colin S. Brown, Ana Atti, Jasmin Islam, Anne M. Presanis, Andre Charlett, Daniela De Angelis, Susan Hopkins, Tracy Lewis, Steve Bain, Rebeccah Thomas, John Geen, Carla Pothecary, Sean Cutler, John Northfield, Cathy Price, Johanne Tomlinson, Sarah Knight, Emily Macnaughton, Ekaterina Watson, Rajeka Lazarus, Aaran Sinclair, Joanne Galliford, Bridgett Masunda, Tabitha Mahungu, Alison Rodger, Esther Hanison, Simon Warren, Swati Jain, Mariyam Mirfenderesky, Natasha Mahabir, Rowan Pritchard-Jones, Diane Wycherley, Claire Gabriel, Elijah Matovu, Philippa Bakker, Simantee Guha, S. Gormley, James Pethick, Georgina Butt, Stacey Pepper, Luke Bedford, Paul Ridley, Jane Democratis, Manjula Meda, Anu Chawla, Fran Westwell, Nagesh Kalakonda, Sheena Khanduri, Allison Doel, Sumita Pai, Christian Hacon, Davis Nwaka, Veronica Mendez Moro, A. Moody, Cressida Auckland, Stephanie Prince, Thushan de Silva, Helen Shulver, A. Shah, C. Jones, Banerjee Subhro-Osuji, Angela Houston, Tim Planche, Martin Booth, Christopher Duff, Jonnie Aeron-Thomas, Ray Chaudhuri, David Hilton, Hannah Jory, Zehra'a Al-Khafaji, Philippa Kemsley, Ruth Longfellow, David Boss, Simon Brake, Louise Coke, Ngozi Elumogo, Scott Latham, Chinari Subudhi, Ina Hoad, Claire Thomas, Nihil Chitalia, Tracy Edmunds, Helen Ashby, John Elliott, Beverley Wilkinson, Abby Rand

“…Background: The protection of fourth dose mRNA vaccination against SARS-CoV-2 is relevant to current global policy decisions regarding ongoing booster…”
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A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities by Sridhar, Sushmita, Forrest, Sally, Kean, Iain, Young, Jamie, Bartholdson Scott, Josefin, Maes, Mailis, Pereira-Dias, Joana, Parmar, Surendra, Routledge, Matthew, Sparkes, Dominic, Rivett, Lucy, Dougan, Gordon, Weekes, Michael, Curran, Martin, Goodfellow, Ian, Baker, Stephen

“…The COVID-19 pandemic is expanding at an unprecedented rate. As a result, diagnostic services are stretched to their limit, and there is a clear need for the…”
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