Search Results - "Sparkes, Amanda"

The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity by Saha, Shrayasee, Sparkes, Amanda, Matus, Esther I., Lee, Peter, Gariépy, Jean

“…PVR (poliovirus receptor) functions as a ligand that signals through TIGIT and CD96 to induce suppression of T-cell and NK-cell responses. Alternatively, PVR…”
Get full text

Agonistic nanobodies and antibodies to human VISTA by Ma, Yu-Heng Vivian, Sparkes, Amanda, Romão, Ema, Saha, Shrayasee, Gariépy, Jean

“…The V-domain Ig Suppressor of T-cell Activation (VISTA) is an immune checkpoint regulator that suppresses immune responses and is readily expressed on human…”
Get full text

MIF contributes to Trypanosoma brucei associated immunopathogenicity development by Stijlemans, Benoît, Leng, Lin, Brys, Lea, Sparkes, Amanda, Vansintjan, Liese, Caljon, Guy, Raes, Geert, Van Den Abbeele, Jan, Van Ginderachter, Jo A, Beschin, Alain, Bucala, Richard, De Baetselier, Patrick

“…African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The…”
Get full text

A soluble activator that favors the ex vivo expansion of CD8+CD27+ T cells by Matus, Esther I, Sparkes, Amanda, Gariépy, Jean

“…Adoptive cell therapy involves the infusion of tumor-reactive T cells into patients with cancer to provide antitumor immunity. The ex vivo expansion and…”
Get full text

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis by Stijlemans, Benoît, Brys, Lea, Korf, Hannelie, Bieniasz-Krzywiec, Pawel, Sparkes, Amanda, Vansintjan, Liese, Leng, Lin, Vanbekbergen, Nele, Mazzone, Massimiliano, Caljon, Guy, Van Den Abbeele, Jan, Odongo, Steven, De Trez, Carl, Magez, Stefan, Van Ginderachter, Jo A, Beschin, Alain, Bucala, Richard, De Baetselier, Patrick

“…Animal African trypanosomosis is a major threat to the economic development and human health in sub-Saharan Africa. Trypanosoma congolense infections represent…”
Get full text

A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo by Prodeus, Aaron, Sparkes, Amanda, Fischer, Nicholas W., Cydzik, Marzena, Huang, Eric, Khatri, Ismat, Young, Ashley, Woo, Lindsay, Chow, Chung Wai, Gorczynski, Reginald, Gariépy, Jean

“…Functional aptamers displaying agonistic or antagonistic properties are showing great promise as modulators of immune responses. Here, we report the…”
Get full text

Novel half‐life extended anti‐MIF nanobodies protect against endotoxic shock by Sparkes, Amanda, De Baetselier, Patrick, Brys, Lea, Cabrito, Inês, Sterckx, Yann G.-J., Schoonooghe, Steve, Muyldermans, Serge, Raes, Geert, Bucala, Richard, Vanlandschoot, Peter, Van Ginderachte, Jo A., Stijlemans, Benoît

Get full text

Murine Liver Myeloid Cell Isolation Protocol by Stijlemans, Benoit, Sparkes, Amanda, Abels, Chlo, Keirsse, Jiri, Brys, Lea, Elkrim, Yvon, Baetselier, Patrick, Beschin, Alain, Ginderachter, Jo

“…In homeostasis, the liver is critical for the metabolism of nutrients including sugars, lipids, proteins and iron, for the clearance of toxins, and to induce…”
Get full text

A powerful ICOS agonist that enhances anti-tumor immune responses restored by immune checkpoint inhibitors by Gariepy, Jean, Prodeus, Aaron, Sparkes, Amanda, Fischer, Nicholas, Saha, Shravasee

“…Abstract The Inducible T cell Costimulator (ICOS, CD278) is a receptor in the CD28 family of B7-binding proteins expressed mostly by activated T cells. Upon…”
Get full text

VISTA as a ligand downregulates LPS-mediated inflammation in macrophages and neutrophils by Vivian Ma, Yu-Heng, Sparkes, Amanda, Saha, Shrayasee, Gariépy, Jean

“…•VISTA is proposed to function both as an immune-modulatory ligand and receptor.•The role of VISTA as a ligand on myeloid cells is largely unstudied.•LPS…”
Get full text

The non-mammalian MIF superfamily by Sparkes, Amanda, De Baetselier, Patrick, Roelants, Kim, De Trez, Carl, Magez, Stefan, Van Ginderachter, Jo A, Raes, Geert, Bucala, Richard, Stijlemans, Benoît

“…Abstract Macrophage migration inhibitory factor (MIF) was first described as a cytokine 50 years ago, and emerged in mammals as a pleiotropic protein with…”
Get full text

Novel half‐life extended anti‐MIF nanobodies protect against endotoxic shock by Sparkes, Amanda, De Baetselier, Patrick, Brys, Lea, Cabrito, Inês, Sterckx, Yann G.-J., Schoonooghe, Steve, Muyldermans, Serge, Raes, Geert, Bucala, Richard, Vanlandschoot, Peter, Van Ginderachte, Jo A., Stijlemans, Benoît

“…ABSTRACT Sepsis—leading to septic shock—is the leading cause of death in intensive care units. The systemic inflammatory response to infection, which is…”
Get full text

Abstract 61: A novel immunotherapy for metastatic prostate cancer: A monoclonal antibody that can bind both STEAP1 and STEAP2 by Sheng, Minzhi, Thillainadesan, Gobi, Sparkes, Amanda, Su, Boyang, Matus, Esther, Wright, Jessica, Liu, Stanley, Gariepy, Jean, Leong, Hon S.

“…Abstract Prostate cancer (PCa) is the second most prevalent cancer among males, and the 5-year survival rate for patients with metastatic PCa (mPCa) is ~30%…”
Get full text

Broadly Applicable Bispecific Linker Approach to Noncovalently Target Therapeutic Nanoparticles to Tumor Cells Expressing Carcinoembryonic Antigen by Fernando, Ann, Sparkes, Amanda, Matus, Esther I., Patel, Ayushi, Foster, F. Stuart, Goertz, David, Lee, Peter, Gariépy, Jean

“…Design strategies that lead to a more focused in vivo delivery of functionalized nanoparticles (NPs) and their cargo can potentially maximize their therapeutic…”
Get full text

Reprint of: The non-mammalian MIF superfamily by Sparkes, Amanda, De Baetselier, Patrick, Roelants, Kim, De Trez, Carl, Magez, Stefan, Van Ginderachter, Jo A, Raes, Geert, Bucala, Richard, Stijlemans, Benoît

“…Abstract Macrophage migration inhibitory factor (MIF) was first described as a cytokine 50 years ago, and emerged in mammals as a pleiotropic protein with…”
Get full text

Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis by Zheng, Fang, Sparkes, Amanda, De Baetselier, Patrick, Schoonooghe, Steve, Stijlemans, Benoit, Muyldermans, Serge, Flamand, Véronique, Van Ginderachter, Jo A, Devoogdt, Nick, Raes, Geert, Beschin, Alain

“…Purpose Kupffer cells (KCs), the liver resident macrophages, are important mediators of tissue homeostasis and pathogen clearance. However, depending on the…”
Get full text

VISTA.COMP - an engineered checkpoint receptor agonist that potently suppresses T cell-mediated immune responses by Prodeus, Aaron, Abdul-Wahid, Aws, Sparkes, Amanda, Fischer, Nicholas W, Cydzik, Marzena, Chiang, Nicholas, Alwash, Mays, Ferzoco, Alessandra, Vacaresse, Nathalie, Julius, Michael, Gorczysnki, Reginald M, Gariépy, Jean

“…V-domain immunoglobulin suppressor of T cell activation (VISTA) is a recently discovered immune checkpoint ligand that functions to suppress T cell activity…”
Get full text

MIF Contributes to Trypanosoma brucei Associated Immunopathogenicity Development: e1004414 by Stijlemans, Benoît, Leng, Lin, Brys, Lea, Sparkes, Amanda, Vansintjan, Liese, Caljon, Guy, Raes, Geert, Abbeele, Jan VanDen, Ginderachter, Jo AVan, Beschin, Alain, Bucala, Richard, Baetselier, Patrick De

“…African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The…”
Get full text

Monitoring liver macrophages using nanobodies targeting Vsig4: Concanavalin A induced acute hepatitis as paradigm by Zheng, Fang, Devoogdt, Nick, Sparkes, Amanda, Morias, Yannick, Abels, Chloé, Stijlemans, Benoit, Lahoutte, Tony, Muyldermans, Serge, De Baetselier, Patrick, Schoonooghe, Steve, Beschin, Alain, Raes, Geert

“…Abstract Kupffer cells (KCs) are liver resident macrophages which are important for tissue homeostasis and have been implicated in immunogenic, tolerogenic and…”
Get full text

Agonistic nanobodies and antibodies to human VISTA by Ma, Yu-Heng Vivian, Sparkes, Amanda, Romão, Ema, Saha, Shrayasee, Gariépy, Jean

“…The V-domain Ig Suppressor of T-cell Activation (VISTA) is an immune checkpoint regulator that suppresses immune responses and is readily expressed on human…”
Get full text