Search Results - "Sparey, Tim"

The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine by Smith, Sean M, Uslaner, Jason M, Yao, Lihang, Mullins, Chadwick M, Surles, Nathan O, Huszar, Sarah L, McNaughton, Caitlyn H, Pascarella, Danette M, Kandebo, Monika, Hinchliffe, Richard M, Sparey, Tim, Brandon, Nicholas J, Jones, Brian, Venkatraman, Shankar, Young, Mary Beth, Sachs, Nancy, Jacobson, Marlene A, Hutson, Peter H

“…Multiple studies indicate that N-methyl-D-aspartate (NMDA) receptor hypofunction underlies some of the deficits associated with schizophrenia. One approach for…”
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The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors by Sparey, Tim, Abeywickrema, Pravien, Almond, Sarah, Brandon, Nick, Byrne, Noel, Campbell, Alister, Hutson, Pete H., Jacobson, Marlene, Jones, Brian, Munshi, Sanjeev, Pascarella, Danette, Pike, Andrew, Prasad, G. Sridhar, Sachs, Nancy, Sakatis, Melanie, Sardana, Vinod, Venkatraman, Shankar, Young, Mary Beth

“…Novel inhibitors of d-amino acid oxidase (DAO) were discovered. In vivo data for compound 1 showed central and peripheral DAO inhibition and increased…”
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Catalytic Asymmetric Sulfimidation by Takada, Hiroya, Nishibayashi, Yoshiaki, Ohe, Kouichi, Uemura, Sakae, Baird, Charlotte P, Sparey, Tim J, Taylor, Paul C

“…A direct catalytic imidation of sulfides to sulfimides with [N-(p-tolylsulfonyl)imino]phenyliodinane (TsNIPh) using a catalytic amount of copper triflate…”
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Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis by Shabo, Ivan, Svanvik, Joar, Lindström, Annelie, Lechertier, Tanguy, Trabulo, Sara, Hulit, James, Sparey, Tim, Pawelek, John

“…Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation, repair and regeneration. Through cell…”
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VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice by Ferjančič, Špela, Gil-Bernabé, Ana M., Hill, Sally A., Allen, Philip D., Richardson, Peter, Sparey, Tim, Savory, Edward, McGuffog, Jane, Muschel, Ruth J.

“…Pulmonary metastasis is a frequent cause of poor outcome in cancer patients. The formation of pulmonary metastasis is greatly facilitated by recruitment of…”
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Impact of Mitochondrial Targeting Antibiotics on Mitochondrial Function and Proliferation of Cancer Cells by Cochrane, Edward J, Hulit, James, Lagasse, Franz P, Lechertier, Tanguy, Stevenson, Brett, Tudor, Corina, Trebicka, Diana, Sparey, Tim, Ratcliffe, Andrew J

“…Some marketed antibiotics can cause mitochondria dysfunction via inhibition of the mitochondrial translation process. There is great interest in exploiting…”
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Learning from each other: an industry academic liaison officer and a university technology-transfer professional in the UK canvass their peers to provide some pointers for how to streamline the technology-transfer process between companies and academia by Sparey, Tim, Gliubich, Francesca

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Synthesis of styryl tetrahydrofurans and tetrahydropyrans via addition of radicals to unsaturated sulfimides by Clark, Andrew J., Rooke, Stuart, Sparey, Tim J., Taylor, Paul C.

“…The addition of tetrahydrofuranyl or tetrahydropyranyl radicals to (E)-styryl sulfimide derivatives furnishes the corresponding (E)-styryl tetrahydrofurans or…”
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Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitors by Sparey, Tim, Clarke, Earl, Hannam, Joanne, Harrison, Timothy, Madin, Andrew, Shearman, Mark, Sohal, Bindi

“…A range of substituents was appended from the bridgehead position of sulfonamide substituted bicyclo[4.2.1]nonanes. No improvement in potency for inhibition of…”
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Cyclic sulfamide γ-secretase inhibitors by Sparey, Tim, Beher, Dirk, Best, Jonathan, Biba, Mirlinda, Castro, José L., Clarke, Earl, Hannam, Joanne, Harrison, Timothy, Lewis, Huw, Madin, Andrew, Shearman, Mark, Sohal, Bindi, Tsou, Nancy, Welch, Christopher, Wrigley, Jonathan

“…A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit. A novel series of N-alkyl-substituted cyclic sulfamides were…”
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ISO 45001: The Benefits of Change by Sparey, Tim

“…If our current EHS management system is working for us, why should we be interested in ISO 45001? OHSAS 18001 has been a very useful standard to help…”
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Inverse electron demand Diels-Alder reactions of 3,6-dichloro-[1,2,4,5]tetrazine by Sparey, Tim J., Harrison, Timothy

“…3,6-Dichloro-[1,2,4,5]tetrazine has been found to act as an efficient azadiene equivalent in inverse electron demand [4+2] cyclisations with a range of alkenes…”
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