Search Results - "Spanton, Stephen G."

The development of an NMR chemical shift prediction application with the accuracy necessary to grade proton NMR spectra for identity by Spanton, Stephen G., Whittern, David

“…We have developed an NMR chemical shift prediction system that enables high throughput automatic grading of NMR spectra. In support of high throughput…”
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Purification of drugs from biological fluids by counter-current chromatography by Hochlowski, Jill E., Pan, Jeffrey Y., Searle, Philip A., Buck, Wayne R., Spanton, Stephen G.

“…Experiments were performed to demonstrate the potential of counter-current chromatography (CCC) for the isolation of drugs and their metabolites from…”
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Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors by Kempf, Dale J, Sowin, Thomas J, Doherty, Elizabeth M, Hannick, Steven M, Codavoci, LynnMarie, Henry, Rodger F, Green, Brian E, Spanton, Stephen G, Norbeck, Daniel W

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5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners by Hochlowski, J E, Mullally, M M, Spanton, S G, Whittern, D N, Hill, P, McAlpine, J B

“…A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the…”
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Stereoselective synthesis of .alpha.-alkyl .alpha.-amino acids. Alkylation of 3-substituted 5H,10bH-oxazolo[3,2-c][1,3]benzoxazine-2(3H),5-diones by Zydowsky, Thomas M, De Lara, Edwin, Spanton, Stephen G

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An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery by Hochlowski, Jill E., Searle, Philip A., Tu, Noah P., Pan, Jeffrey Y., Spanton, Stephen G., Djuric, Stevan W.

“…We report herein a high-throughput integrated synthesis—purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that…”
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Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue by Rosenberg, Saul H, Woods, Keith W, Kleinert, Hollis D, Stein, Herman, Nellans, Hugh N, Hoffman, Daniel J, Spanton, Stephen G, Pyter, Richard A, Cohen, Jerome

“…Azidomethyl-substituted 1,2- and 1,3-diols were prepared from Boc-cyclohexylalanal and evaluated as transition state analogue renin inhibitors, leading to the…”
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Determination of fortimicin A and 3-O-demethylfortimicin A as 3,5-dinitrobenzoyl derivatives by reverse-phase high-performance liquid chromatography by Elrod, Lee, White, Landy B, Spanton, Stephen G, Stroz, David G, Cugier, Phyllis J, Luka, Loretta A

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Structure of 3.alpha.-hydroxy-15-rippertene. Evidence for 1,2-methyl migration during biogenesis of a tetracyclic diterpene in termites by Prestwich, Glenn D, Spanton, Stephen G, Lauher, Joseph W, Vrkoc, Jan

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Spenolimycin, a new spectinomycin-type antibiotic. II. Isolation and structure determination by McAlpine, J B, Brill, G M, Spanton, S G, Mueller, S L, Stanaszek, R S

“…A new water-soluble, basic antibiotic has been isolated from the fermentation beers of Streptomyces gilvospiralis sp. nov. The structure of the antibiotic has…”
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Stereocontrolled synthesis of psi[CH = CH] dipeptide isosteres by Kempf, D J, Wang, X C, Spanton, S G

“…A new stereocontrolled synthesis of the psi[CH = CH] dipeptide isostere is described. They key step of the sequence relies on the stereospecific…”
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