Search Results - "Spann, Nathanael J."

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities by Gosselin, David, Link, Verena M., Romanoski, Casey E., Fonseca, Gregory J., Eichenfield, Dawn Z., Spann, Nathanael J., Stender, Joshua D., Chun, Hyun B., Garner, Hannah, Geissmann, Frederic, Glass, Christopher K.

“…Macrophages reside in essentially all tissues of the body and play key roles in innate and adaptive immune responses. Distinct populations of tissue…”
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Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription by Kaikkonen, Minna U., Spann, Nathanael J., Heinz, Sven, Romanoski, Casey E., Allison, Karmel A., Stender, Joshua D., Chun, Hyun B., Tough, David F., Prinjha, Rab K., Benner, Christopher, Glass, Christopher K.

“…Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers,…”
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The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response by Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Kropp, Kai A., Forster, Thorsten, Shui, Guanghou, Lacaze, Paul, Watterson, Steven, Griffiths, Samantha J., Spann, Nathanael J., Meljon, Anna, Talbot, Simon, Krishnan, Kathiresan, Covey, Douglas F., Wenk, Markus R., Craigon, Marie, Ruzsics, Zsolts, Haas, Jürgen, Angulo, Ana, Griffiths, William J., Glass, Christopher K., Wang, Yuqin, Ghazal, Peter

“…Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN…”
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Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20 by Stender, Joshua D., Pascual, Gabriel, Liu, Wen, Kaikkonen, Minna U., Do, Kevin, Spann, Nathanael J., Boutros, Michael, Perrimon, Norbert, Rosenfeld, Michael G., Glass, Christopher K.

“…Regulation of genes that initiate and amplify inflammatory programs of gene expression is achieved by signal-dependent exchange of coregulator complexes that…”
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Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine by Pirzgalska, Roksana M, Seixas, Elsa, Seidman, Jason S, Link, Verena M, Sánchez, Noelia Martínez, Mahú, Inês, Mendes, Raquel, Gres, Vitka, Kubasova, Nadiya, Morris, Imogen, Arús, Bernardo A, Larabee, Chelsea M, Vasques, Miguel, Tortosa, Francisco, Sousa, Ana L, Anandan, Sathyavathy, Tranfield, Erin, Hahn, Maureen K, Iannacone, Matteo, Spann, Nathanael J, Glass, Christopher K, Domingos, Ana I

“…Sympathetic neuron–associated macrophages act as a local sink for norepinephrine, leading to reduced thermogenesis and increased obesity. The cellular…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism by Oishi, Yumiko, Spann, Nathanael J., Link, Verena M., Muse, Evan D., Strid, Tobias, Edillor, Chantle, Kolar, Matthew J., Matsuzaka, Takashi, Hayakawa, Sumio, Tao, Jenhan, Kaikkonen, Minna U., Carlin, Aaron F., Lam, Michael T., Manabe, Ichiro, Shimano, Hitoshi, Saghatelian, Alan, Glass, Christopher K.

“…Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize…”
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NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids by Li, Pingping, Spann, Nathanael J., Kaikkonen, Minna U., Lu, Min, Oh, Da Young, Fox, Jesse N., Bandyopadhyay, Gautam, Talukdar, Saswata, Xu, Jianfeng, Lagakos, William S., Patsouris, David, Armando, Aaron, Quehenberger, Oswald, Dennis, Edward A., Watkins, Steven M., Auwerx, Johan, Glass, Christopher K., Olefsky, Jerrold M.

“…Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway…”
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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis by Sun, Xiaoli, Seidman, Jason S., Zhao, Peng, Troutman, Ty D., Spann, Nathanael J., Que, Xuchu, Zhou, Fangli, Liao, Zhongji, Pasillas, Martina, Yang, Xiaohong, Magida, Jason A., Kisseleva, Tatiana, Brenner, David A., Downes, Michael, Evans, Ronald M., Saltiel, Alan R., Tsimikas, Sotirios, Glass, Christopher K., Witztum, Joseph L.

“…Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis…”
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages by Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.

“…Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models…”
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Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages by Fonseca, Gregory J., Tao, Jenhan, Westin, Emma M., Duttke, Sascha H., Spann, Nathanael J., Strid, Tobias, Shen, Zeyang, Stender, Joshua D., Sakai, Mashito, Link, Verena M., Benner, Christopher, Glass, Christopher K.

“…Mechanisms by which members of the AP-1 family of transcription factors play non-redundant biological roles despite recognizing the same DNA sequence remain…”
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Transcription factor ISL1 is essential for pacemaker development and function by Liang, Xingqun, Zhang, Qingquan, Cattaneo, Paola, Zhuang, Shaowei, Gong, Xiaohui, Spann, Nathanael J, Jiang, Cizhong, Cao, Xinkai, Zhao, Xiaodong, Zhang, Xiaoli, Bu, Lei, Wang, Gang, Chen, H S Vincent, Zhuang, Tao, Yan, Jie, Geng, Peng, Luo, Lina, Banerjee, Indroneal, Chen, Yihan, Glass, Christopher K, Zambon, Alexander C, Chen, Ju, Sun, Yunfu, Evans, Sylvia M

“…The sinoatrial node (SAN) maintains a rhythmic heartbeat; therefore, a better understanding of factors that drive SAN development and function is crucial to…”
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ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge’s disease by Azad, Priti, Caldwell, Andrew B., Ramachandran, Srinivasan, Spann, Nathanael J., Akbari, Ali, Villafuerte, Francisco C., Bermudez, Daniela, Zhao, Helen, Poulsen, Orit, Zhou, Dan, Bafna, Vineet, Subramaniam, Shankar, Haddad, Gabriel G.

“…At high altitude Andean region, hypoxia-induced excessive erythrocytosis (EE) is the defining feature of Monge’s disease or chronic mountain sickness (CMS). At…”
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Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages by Eichenfield, Dawn Z, Troutman, Ty Dale, Link, Verena M, Lam, Michael T, Cho, Han, Gosselin, David, Spann, Nathanael J, Lesch, Hanna P, Tao, Jenhan, Muto, Jun, Gallo, Richard L, Evans, Ronald M, Glass, Christopher K

“…Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their…”
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Txnip balances metabolic and growth signaling via PTEN disulfide reduction by Hui, Simon T.Y, Andres, Allen M, Miller, Amber K, Spann, Nathanael J, Potter, Douglas W, Post, Noah M, Chen, Amelia Z, Sachithanantham, Sowbarnika, Jung, Dae Young, Kim, Jason K, Davis, Roger A

“…Thioredoxin-interacting protein (Txnip) inhibits thioredoxin NADPH-dependent reduction of protein disulfides. Total Txnip knockout (TKO) mice adapted…”
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An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells by Texari, Lorane, Spann, Nathanael J., Troutman, Ty D., Sakai, Mashito, Seidman, Jason S., Heinz, Sven

“…Integrative analysis of next-generation sequencing data can help understand disease mechanisms. Specifically, ChIP-seq can illuminate where transcription…”
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Sterols and oxysterols in immune cell function by Spann, Nathanael J, Glass, Christopher K

“…Sterols and oxysterol derivatives of cholesterol regulate diverse cellular processes. Nathanael Spann and Christopher Glass review the emerging data indicating…”
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Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities by Gosselin, David, Link, Verena M., Romanoski, Casey E., Fonseca, Gregory J., Eichenfield, Dawn Z., Spann, Nathanael J., Stender, Joshua D., Chun, Hyun B., Garner, Hannah, Geissmann, Frederic, Glass, Christopher K.

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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity by Sakai, Mashito, Troutman, Ty D., Seidman, Jason S., Ouyang, Zhengyu, Spann, Nathanael J., Abe, Yohei, Ego, Kaori M., Bruni, Cassi M., Deng, Zihou, Schlachetzki, Johannes C.M., Nott, Alexi, Bennett, Hunter, Chang, Jonathan, Vu, BaoChau T., Pasillas, Martina P., Link, Verena M., Texari, Lorane, Heinz, Sven, Thompson, Bonne M., McDonald, Jeffrey G., Geissmann, Frederic, Glass, Christopher K.

“…Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular…”
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Coordinate Transcriptional Repression of Liver Fatty Acid-binding Protein and Microsomal Triglyceride Transfer Protein Blocks Hepatic Very Low Density Lipoprotein Secretion without Hepatosteatosis by Spann, Nathanael J., Kang, Sohye, Li, Andrew C., Chen, Amelia Z., Newberry, Elizabeth P., Davidson, Nicholas O., Hui, Simon T.Y., Davis, Roger A.

“…Unlike the livers of humans and mice, and most hepatoma cells, which accumulate triglycerides when treated with microsomal triglyceride transfer protein (MTP)…”
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