Search Results - "Spanjaard, Aldo"

Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model by de Groot, Daniel, Spanjaard, Aldo, Hogenbirk, Marc A, Jacobs, Heinz

“…Chromothripsis defines a genetic phenomenon where up to hundreds of clustered chromosomal rearrangements can arise in a single catastrophic event. The…”
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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation by Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C M, Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J I, Pardieck, Iris N, Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E J, Jacobs, Heinz

“…The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( ) repertoires…”
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Strategy for Development of Site-Specific Ubiquitin Antibodies by van Kruijsbergen, Ila, Mulder, Monique P C, Uckelmann, Michael, van Welsem, Tibor, de Widt, John, Spanjaard, Aldo, Jacobs, Heinz, El Oualid, Farid, Ovaa, Huib, van Leeuwen, Fred

“…Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent…”
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CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness by Ahrends, Tomasz, Spanjaard, Aldo, Pilzecker, Bas, Bąbała, Nikolina, Bovens, Astrid, Xiao, Yanling, Jacobs, Heinz, Borst, Jannie

“…CD4+ T cells optimize the cytotoxic T cell (CTL) response in magnitude and quality, by unknown molecular mechanisms. We here present the transcriptomic changes…”
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Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine by Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz

“…Abstract Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion…”
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Mammalian life depends on two distinct pathways of DNA damage tolerance by Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz

“…DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance…”
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Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair by Shah, Ronak, Aslam, Muhammad Assad, Spanjaard, Aldo, de Groot, Daniel, Zürcher, Lisa M, Altelaar, Maarten, Hoekman, Liesbeth, Pritchard, Colin E J, Pilzecker, Bas, van den Berk, Paul C M, Jacobs, Heinz

“…The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS). TLS is…”
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