Search Results - "Spangfort, Michael D."

Specific IgG4 production during house dust mite immunotherapy among age, gender and allergic disease populations by Lai, Xuxin, Li, Jing, Xiao, Xiaoxiong, Liu, Enmei, Zhang, Chunqing, Wang, Hongyu, Gjesing, Birgitte, Zhong, Nanshan, Spangfort, Michael D

“…Specific IgG4 induced by allergen-specific immunotherapy (SIT) is an immunological marker related to the appearance of clinical tolerance. But specific IgG4…”
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Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients by Li, Jing, Huang, Ying, Lin, Xiaoping, Zhao, Deyu, Tan, Guolin, Wu, Jinzhun, Zhao, Changqing, Zhao, Jing, Spangfort, Michael D, Zhong, Nanshan

“…The association between sensitizations and severity of allergic diseases is controversial. This study was to investigate the association between severity of…”
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The Major Birch Allergen, Bet v 1, Shows Affinity for a Broad Spectrum of Physiological Ligands by Mogensen, Jesper E., Wimmer, Reinhard, Larsen, Jørgen N., Spangfort, Michael D., Otzen, Daniel E.

“…Bet v 1 is a 17-kDa protein abundantly present in the pollen of the White birch tree and is the primary cause of birch pollen allergy in humans. Its…”
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Epitope Grafting, Re-creating a Conformational Bet v 1 Antibody Epitope on the Surface of the Homologous Apple Allergen Mal d 1 by Holm, Jens, Ferreras, Mercedes, Ipsen, Henrik, Würtzen, Peter A., Gajhede, Michael, Larsen, Jørgen N., Lund, Kaare, Spangfort, Michael D.

“…Birch-allergic patients often experience oral allergy syndrome upon ingestion of vegetables and fruits, most prominently apple, that is caused by antibody…”
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Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients by Zheng, Yi-Wu, Li, Jing, Lai, Xu-Xin, Zhao, De-Yu, Liu, Xiao-Fan, Lin, Xiao-Ping, Gjesing, Birgitte, Palazzo, Paola, Mari, Adriano, Zhong, Nan-Shan, Spangfort, Michael D

“…Background Allergen micro-arrays are powerful tools for screening of serum IgE-reactivity. In this study allergen micro-arrays were used to identify dominating…”
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Structure and biology of stinging insect venom allergens by King, T P, Spangfort, M D

“…Bees, fire ants and vespids cause insect sting allergy. These insects have unique as well as common venom allergens. Vespids, including hornets, paper wasps…”
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The Crystal Structure of Recombinant proDer p 1, a Major House Dust Mite Proteolytic Allergen by Meno, Kare, Thorsted, Peter B, Ipsen, Henrik, Kristensen, Ole, Larsen, Jorgen N, Spangfort, Michael D, Gajhede, Michael, Lund, Kaare

“…Allergy to house dust mite is among the most prevalent allergic diseases worldwide. Most house dust mite allergic patients react to Der p 1 from…”
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Dominant Epitopes and Allergic Cross-Reactivity: Complex Formation Between a Fab Fragment of a Monoclonal Murine IgG Antibody and the Major Allergen from Birch Pollen Bet v 1 by Mirza, Osman, Henriksen, Anette, Ipsen, Henrik, Larsen, Jorgen N, Wissenbach, Margit, Spangfort, Michael D, Gajhede, Michael

“…The symptoms characteristic of allergic hypersensitivity are caused by the release of mediators, i.e., histamine, from effector cells such as basophils and…”
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Legends of Allergy and Immunology: From a curious mind to a world class scientist—A brief biography of Professor T.P. King by Ferreira, Fatima, Hubinger, Gudrun, Spangfort, Michael D.

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Indoor mite allergen levels, specific IgE prevalence and IgE cross-inhibition pattern among asthmatic children in Haikou, southern China by Zheng, Yi-Wu, Chen, Shi, Lai, Xu-Xin, Gjesing, Birgitte, Zhong, Nan-Shan, Spangfort, Michael D

“…Background Haikou locates in tropical island with unique mite allergens levels in Haikou, and to investigate the prevalence of between house dust mites…”
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Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China by Hao, Guo-dong, Zheng, Yi-wu, Gjesing, Birgitte, Kong, Xing-ai, Wang, Jing-yuan, Song, Zhi-jing, Lai, Xu-xin, Zhong, Nan-shan, Spangfort, Michael D.

“…Objective： Weed pollens are common sources of allergens worldwide. The prevalence of weed pollen sensitization is not yet fully known in China. The purpose of…”
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Prevention of allergy by a recombinant multi‐allergen vaccine with reduced IgE binding and preserved T cell epitopes by Karamloo, Fariba, Schmid‐Grendelmeier, Peter, Kussebi, Fatimah, Akdis, Mübeccel, Salagianni, Maria, von Beust, Barbara R., Reimers, Andrea, Zumkehr, Judith, Soldatova, Lyudmilla, Housley‐Markovic, Zora, Müller, Ulrich, Kündig, Thomas, Kemeny, David M., Spangfort, Michael D., Blaser, Kurt, Akdis, Cezmi A.

“…Novel approaches for the prevention of allergy are required, because of the inevitably increasing prevalence of allergic diseases during the last 30 years…”
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Allergy Vaccine Engineering: Epitope Modulation of Recombinant Bet v 1 Reduces IgE Binding but Retains Protein Folding Pattern for Induction of Protective Blocking-Antibody Responses by Holm, Jens, Gajhede, Michael, Ferreras, Mercedes, Henriksen, Anette, Ipsen, Henrik, Larsen, Jorgen N, Lund, Lise, Jacobi, Henrik, Millner, Anders, Wurtzen, Peter A, Spangfort, Michael D

“…Human type 1 immediate allergic response symptoms are caused by mediator release from basophils and mast cells. This event is triggered by allergens…”
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The Functional IgE-Blocking Factor Induced by Allergen-Specific Immunotherapy Correlates with IgG4 Antibodies and a Decrease of Symptoms in House Dust Mite-Allergic Children by Zhao, Deyu, Lai, Xuxin, Tian, Man, Jiang, Yanhe, Zheng, Yiwu, Gjesing, Birgitte, Zhong, Nanshan, Spangfort, Michael D

“…At present, there are no validated biomarkers reflecting or predicting the clinical efficacy of allergen-specific immunotherapy (AIT) . We aimed to investigate…”
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House dust mite and storage mite IgE reactivity in allergic patients from Guangzhou, China by Zhang, Chunqing, Li, Jing, Lai, Xuxin, Zheng, Yiwu, Gjesing, Birgitte, Spangfort, Michael D, Zhong, Nanshan

“…In China, house dust mites are important inducers of allergic disease. The importance of allergens from storage mites is less well known. The aim of this study…”
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Indoor Allergen Levels and Household Distributions in Nine Cities Across China by Zheng, Yi Wu, Lai, Xu Xin, Zhao, De Yu, Zhang, Chun Qing, Chen, Jian Jun, Zhang, Luo, Wei, Qing Yu, Chen, Shi, Liu, En Mei, Norback, Dan, Gjesing, Birgitte, Zhong, Nan Shan, Spangfort, D Michael

“…Chinese allergic subjects have high levels of sensitization to house dust mite (HDM) and other indoor allergens. This study quantifies common indoor allergen…”
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Allergens as eukaryotic proteins lacking bacterial homologues by Emanuelsson, Cecilia, Spangfort, Michael D.

“…Only a small number of protein homologues cause the majority of allergies. There is no consensus structure or other obvious common denominator discriminating…”
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X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy by Gajhede, Michael, Osmark, Peter, Poulsen, Flemming M, Ipsen, Henrik, Larsen, Jørgen N, van Neerven, R.J. Joost, Schou, Carsten, Løwenstein, Henning, Spangfort, Michael D

“…The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as…”
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High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China by Hao, Guo-dong, Zheng, Yi-wu, Wang, Zhi-xiang, Kong, Xing-ai, Song, Zhi-jing, Lai, Xu-xin, Spangfort, Michael D.

“…Background Birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. Methods Sera from 203…”
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Dominating IgE-Binding Epitope of Bet v 1, the Major Allergen of Birch Pollen, Characterized by X-ray Crystallography and Site-Directed Mutagenesis by Spangfort, Michael D, Mirza, Osman, Ipsen, Henrik, van Neerven, R. J. Joost, Gajhede, Michael, Larsen, Jorgen N

“…Specific allergy vaccination is an efficient treatment for allergic disease; however, the development of safer vaccines would enable a more general use of the…”
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