Search Results - "Spanagel, R."

Neuropharmacology of alcohol addiction by Vengeliene, V, Bilbao, A, Molander, A, Spanagel, R

“…Despite the generally held view that alcohol is an unspecific pharmacological agent, recent molecular pharmacology studies demonstrated that alcohol has only a…”
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Key role of loss of corticostriatal mGluR2 in the pathophysiology of alcoholism by Spanagel, R

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PL.01.01 New targets for the treatment of addiction by Spanagel, R

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Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex by Pfarr, Simone, Meinhardt, Marcus W, Klee, Manuela L, Hansson, Anita C, Vengeliene, Valentina, Schönig, Kai, Bartsch, Dusan, Hope, Bruce T, Spanagel, Rainer, Sommer, Wolfgang H

“…Loss of control over drinking is a key deficit in alcoholism causally associated with malfunction of the medial prefrontal cortex (mPFC), but underlying…”
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The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology by Schumann, G, Loth, E, Banaschewski, T, Barbot, A, Barker, G, Büchel, C, Conrod, P J, Dalley, J W, Flor, H, Gallinat, J, Garavan, H, Heinz, A, Itterman, B, Lathrop, M, Mallik, C, Mann, K, Martinot, J-L, Paus, T, Poline, J-B, Robbins, T W, Rietschel, M, Reed, L, Smolka, M, Spanagel, R, Speiser, C, Stephens, D N, Ströhle, A, Struve, M

“…A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study…”
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Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior by Broccoli, L., Uhrig, S., von Jonquieres, G., Schönig, K., Bartsch, D., Justice, N. J., Spanagel, R., Sommer, W. H., Klugmann, M., Hansson, A. C.

“…Rationale The corticotropin-releasing hormone (CRH) system is a key mediator of stress-induced responses in alcohol-seeking behavior. Recent research has…”
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S.14.02 Glutamatergic mechanisms in alcohol addiction by Spanagel, R

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Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice by Strekalova, T, Spanagel, R, Dolgov, O, Bartsch, D

“…Chronic stress is broadly used to model anxiety and depression. However, in chronic stress models, anxiety- and depression-like behaviors might be masked by…”
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Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate by Kiefer, F, Witt, S H, Frank, J, Richter, A, Treutlein, J, Lemenager, T, Nöthen, M M, Cichon, S, Batra, A, Berner, M, Wodarz, N, Zimmermann, U S, Spanagel, R, Wiedemann, K, Smolka, M N, Heinz, A, Rietschel, M, Mann, K

“…In alcoholism, both relapse to alcohol drinking and treatment response are suggested to be genetically modulated. This study set out to determine whether the…”
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Addiction and its brain science by Spanagel, Rainer, Heilig, Markus

“…ABSTRACT Aims  To illustrate how modern neurobiological approaches will help to identify the neurocircuits and genes involved in addictive behavior. Background…”
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Genetic association of the human corticotropin releasing hormone receptor 1 ( ) with binge drinking and alcohol intake patterns in two independent samples by TREUTLEIN, J, KISSLING, C, RUJESCU, D, SKOWRONEK, M. H, RIETSCHEL, M, SPANAGEL, R, HEINZ, A, LAUCHT, M, MANN, K, SCHUMANN, G, FRANK, J, WIEMANN, S, DONG, L, DEPNER, M, SAAM, C, LASCORZ, J, SOYKA, M, PREUSS, U. W

“…To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in patterns of human alcohol drinking and its potential contribution to…”
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P.6.c.009 The role of ras guanine nucleotide-releasing factor 1 (ras-GRF1) in cocaine self-administration by Olevska, A, Bernardi, R.E, Brambilla, R, Spanagel, R

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P.6.a.007 The role of glutamatergic receptors within the dopaminergic reinforcement system in alcohol-dependent phenotypes by Eisenhardt, M, Leixner, S, Bilbao, A, Spanagel, R

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Translational FDG-PET studies in alcohol and cocaine addicted rats by Spanagel, R, Cannella, N, Vengeliene, V, Cosa-Linan, A, Takahashi, T

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A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology by Bernardi, R E, Zohsel, K, Hirth, N, Treutlein, J, Heilig, M, Laucht, M, Spanagel, R, Sommer, W H

“…It has been proposed that vulnerability to nicotine addiction is moderated by variation at the μ-opioid receptor locus (OPRM1), but results from human studies…”
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P.2.008 The role of glutamatergic receptors within the dopaminergic reinforcement system in alcohol-dependent phenotypes by Eisenhardt, M, Leixner, S, Bilbao, A, Spanagel, R

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P.2.019 The role of Ras guanine nucleotide-releasing factor 1 in cocaine self-administration by Olevska, A, Bernardi, R.E, Brambilla, R, Spanagel, R

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Boys do it the right way: Sex-dependent amygdala lateralization during face processing in adolescents by Schneider, S., Peters, J., Bromberg, U., Brassen, S., Menz, M.M., Miedl, S.F., Loth, E., Banaschewski, T., Barbot, A., Barker, G., Conrod, P.J., Dalley, J.W., Flor, H., Gallinat, J., Garavan, H., Heinz, A., Itterman, B., Mallik, C., Mann, K., Artiges, Eric, Paus, T., Poline, J.-B., Rietschel, M., Reed, L., Smolka, M.N., Spanagel, R., Speiser, C., Ströhle, A., Struve, M., Schumann, G., Büchel, C.

“…Previous studies have observed a sex-dependent lateralization of amygdala activation related to emotional memory. Specifically, it was shown that the activity…”
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Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder by Zieker, J, Zieker, D, Jatzko, A, Dietzsch, J, Nieselt, K, Schmitt, A, Bertsch, T, Fassbender, K, Spanagel, R, Northoff, H, Gebicke-Haerter, P J

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Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens by Hadar, R, Vengeliene, V, Barroeta Hlusicke, E, Canals, S, Noori, H R, Wieske, F, Rummel, J, Harnack, D, Heinz, A, Spanagel, R, Winter, C

“…Case reports indicate that deep-brain stimulation in the nucleus accumbens may be beneficial to alcohol-dependent patients. The lack of clinical trials and our…”
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