Search Results - "Spana, Eric"

A paired-end sequencing strategy to map the complex landscape of transcription initiation by Ohler, Uwe, Zhu, Jun, Ni, Ting, Corcoran, David L, Rach, Elizabeth A, Song, Shen, Spana, Eric P, Gao, Yuan

“…Paired-end reads consisting of 5′ transcription start sites and 3′ downstream sequences from transcripts in Drosophila melanogaster reveal distinct initiation…”
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Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila by Reitman, Zachary J., Sinenko, Sergey A., Spana, Eric P., Yan, Hai

“…Gain-of-function mutations in nicotinamide adenine dinucleotide phosphate–dependent isocitrate dehydrogenase (IDH)1 and IDH2 frequently arise in human…”
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Sprinter: a novel transmembrane protein required for Wg secretion and signaling by Goodman, Robyn M, Thombre, Shreya, Firtina, Zeynep, Gray, Dione, Betts, Daniella, Roebuck, Jamie, Spana, Eric P, Selva, Erica M

“…Wingless (Wg) is a secreted ligand that differentially activates gene expression in target tissues. It belongs to the Wnt family of secreted signaling…”
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Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila by Seeds, Andrew M, Tsui, Marco M, Sunu, Christine, Spana, Eric P, York, John D

“…Inositol phosphate kinase 2 (Ipk2), also known as IP multikinase IPMK, is an evolutionarily conserved protein that initiates production of inositol phosphate…”
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Expression in aneuploid Drosophila S2 cells by Zhang, Yu, Malone, John H, Powell, Sara K, Periwal, Vipul, Spana, Eric, Macalpine, David M, Oliver, Brian

“…Extensive departures from balanced gene dose in aneuploids are highly deleterious. However, we know very little about the relationship between gene copy number…”
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speck , First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene by Spana, Eric P, Abrams, Amanda B, Ellis, Katharine T, Klein, Jason C, Ruderman, Brandon T, Shi, Alvin H, Zhu, Daniel, Stewart, Andrea, May, Susan

“…The pigmentation mutation is a commonly used recombination marker characterized by a darkly pigmented region at the wing hinge. Identified in 1910 by Thomas…”
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Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control by Maynard, Jason C., Pham, Trang, Zheng, Tianli, Jockheck-Clark, Angela, Rankin, Helen B., Newgard, Christopher B., Spana, Eric P., Nicchitta, Christopher V.

“…GRP94, the endoplasmic reticulum Hsp90, is a metazoan-restricted chaperone essential for early development in mammals, yet dispensable for mammalian cell…”
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BMP Signaling Is Required for Controlling Somatic Stem Cell Self-Renewal in the Drosophila Ovary by Kirilly, Daniel, Spana, Eric P., Perrimon, Norbert, Padgett, Richard W., Xie, Ting

“…BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell…”
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A new resource for characterizing X-linked genes in Drosophila melanogaster: systematic coverage and subdivision of the X chromosome with nested, Y-linked duplications by Cook, R Kimberley, Deal, Megan E, Deal, Jennifer A, Garton, Russell D, Brown, C Adam, Ward, Megan E, Andrade, Rachel S, Spana, Eric P, Kaufman, Thomas C, Cook, Kevin R

“…Interchromosomal duplications are especially important for the study of X-linked genes. Males inheriting a mutation in a vital X-linked gene cannot survive…”
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neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions by Sasamura, Takeshi, Sasaki, Nobuo, Miyashita, Fumiyasu, Nakao, Shiho, Ishikawa, Hiroyuki O, Ito, Mikiko, Kitagawa, Motoo, Harigaya, Kenichi, Spana, Eric, Bilder, David, Perrimon, Norbert, Matsuno, Kenji

“…Notch signalling, which is highly conserved from nematodes to mammals, plays crucial roles in many developmental processes. In the Drosophila embryo,…”
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Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell Fates by Spana, Eric P, Doe, Chris Q

“…Asymmetric cell divisions play a key role in establishing neuronal diversity in the mammalian and Drosophila CNS, but the mechanisms involved are mostly…”
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A Molecular Basis for Inositol Polyphosphate Synthesis in Drosophila melanogaster by Seeds, Andrew M, Sandquist, Joshua C, Spana, Eric P, York, John D

“…Metabolism of inositol 1,4,5-trisphosphate (I(1,4,5)P 3 ) results in the production of diverse arrays of inositol polyphosphates (IPs), such as IP 4 , IP 5 ,…”
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The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP by Cabrero, Pablo, Radford, Jonathan C, Broderick, Kate E, Costes, Laurence, Veenstra, Jan A, Spana, Eric P, Davies, Shireen A, Dow, Julian A T

“…Dh, the gene that encodes a CRF-like peptide in Drosophila melanogaster, is described. The product of this gene is a 44-amino-acid peptide (Drome-DH(44)) with…”
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The fruitless Gene Is Required for the Proper Formation of Axonal Tracts in the Embryonic Central Nervous System of Drosophila by Song, Ho-Juhn, Billeter, Jean-Christophe, Reynaud, Enrique, Carlo, Troy, Spana, Eric P, Perrimon, Norbert, Goodwin, Stephen F, Baker, Bruce S, Taylor, Barbara J

“…The fruitless (fru) gene in Drosophila melanogaster is a multifunctional gene that has sex-specific functions in the regulation of male sexual behavior and…”
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RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila by CAMPBELL, G, GÖRING, H, LIN, T, SPANA, E, ANDERSSON, S, DOE, C. Q, TOMLINSON, A

“…We report the identification of RK2, a glial-specific homeodomain protein. RK2 is localized to the nucleus of virtually all embryonic and imaginal glial cells,…”
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The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila by Spana, E P, Doe, C Q

“…Both intrinsic and extrinsic factors are known to regulate sibling cell fate. Here we describe a novel mechanism for the asymmetric localization of a…”
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Mapping Drosophila genomic aberration breakpoints with comparative genome hybridization on microarrays by Erickson, Jeremy N, Spana, Eric P

“…Chromosomal aberrations are genetic "reagents" that are commonly used in Drosophila research. Stocks containing chromosomes carrying large deletions of DNA…”
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Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS by Spana, E P, Kopczynski, C, Goodman, C S, Doe, C Q

“…The central nervous system (CNS) represents an excellent model system for examining how a multitude of unique cell fates are specified. We find that asymmetric…”
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Biochemical Analysis of Prospero Protein during Asymmetric Cell Division: Cortical Prospero Is Highly Phosphorylated Relative to Nuclear Prospero by Srinivasan, Shaila, Peng, Chian-Yu, Nair, Sai, Skeath, James B, Spana, Eric P, Doe, Chris Q

“…Drosophilaneuroblasts are a model system for studying asymmetric cell division. Neuroblasts bud off a series of smaller progeny, called ganglion mother cells…”
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Inositol phosphate kinase 2 is required for imaginal disc development inDrosophila by Seeds, Andrew M., Tsui, Marco M., Sunu, Christine, Spana, Eric P., York, John D.

“…Inositol phosphate kinase 2 (Ipk2), also known as IPmultikinase IPMK, is an evolutionarily conserved protein that initiates production of inositol phosphate…”
Get full text