Search Results - "Spanò, Virginia"

Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms by Schillaci, Domenico, Spanò, Virginia, Parrino, Barbara, Carbone, Anna, Montalbano, Alessandra, Barraja, Paola, Diana, Patrizia, Cirrincione, Girolamo, Cascioferro, Stella

“…There is urgent need for new therapeutic strategies to fight the global threat of antibiotic resistance. The focus of this Perspective is on chemical agents…”
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11H‑Pyrido[3′,2′:4,5]pyrrolo[3,2‑c]cinnoline and Pyrido[3′,2′:4,5]pyrrolo[1,2‑c][1,2,3]benzotriazine: Two New Ring Systems with Antitumor Activity by Parrino, Barbara, Carbone, Anna, Muscarella, Marina, Spanò, Virginia, Montalbano, Alessandra, Barraja, Paola, Salvador, Alessia, Vedaldi, Daniela, Cirrincione, Girolamo, Diana, Patrizia

“…Derivatives of new ring systems 11H-pyrido[3′,2′:4,5]pyrrolo[3,2-c]cinnoline and pyrido[3′,2′:4,5]pyrrolo[1,2-c][1,2,3]benzotriazine have been prepared from…”
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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes by Barreca, Marilia, Spanò, Virginia, Montalbano, Alessandra, Cueto, Mercedes, Díaz Marrero, Ana R, Deniz, Irem, Erdoğan, Ayşegül, Lukić Bilela, Lada, Moulin, Corentin, Taffin-de-Givenchy, Elisabeth, Spriano, Filippo, Perale, Giuseppe, Mehiri, Mohamed, Rotter, Ana, P Thomas, Olivier, Barraja, Paola, Gaudêncio, Susana P, Bertoni, Francesco

“…The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique…”
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Bioactive pyrrole-based compounds with target selectivity by Li Petri, Giovanna, Spanò, Virginia, Spatola, Roberto, Holl, Ralph, Raimondi, Maria Valeria, Barraja, Paola, Montalbano, Alessandra

“…The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in medicinal chemistry. Natural products have inspired the…”
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1,3,5-Triazines: A promising scaffold for anticancer drugs development by Cascioferro, Stella, Parrino, Barbara, Spanò, Virginia, Carbone, Anna, Montalbano, Alessandra, Barraja, Paola, Diana, Patrizia, Cirrincione, Girolamo

“…This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the…”
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Pyrrolo[2′,3′:3,4]cyclohepta[1,2‑d][1,2]­oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types by Spanò, Virginia, Rocca, Roberta, Barreca, Marilia, Giallombardo, Daniele, Montalbano, Alessandra, Carbone, Anna, Raimondi, Maria Valeria, Gaudio, Eugenio, Bortolozzi, Roberta, Bai, Ruoli, Tassone, Pierfrancesco, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Bertoni, Francesco, Barraja, Paola

“…A new class of pyrrolo­[2′,3′:3,4]­cyclohepta­[1,2-d]­[1,2]­oxazoles was synthesized for the treatment of hyperproliferative pathologies, including neoplasms…”
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Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds by Li Petri, Giovanna, Raimondi, Maria Valeria, Spanò, Virginia, Holl, Ralph, Barraja, Paola, Montalbano, Alessandra

“…The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human…”
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An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds by Cascioferro, Stella, Parrino, Barbara, Spanò, Virginia, Carbone, Anna, Montalbano, Alessandra, Barraja, Paola, Diana, Patrizia, Cirrincione, Girolamo

“…The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides,…”
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Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine, a new ring system as potential COX inhibitor by Migliara, Onofrio, Spanò, Virginia, Parrino, Barbara, Ciancimino, Cristina, Diana, Patrizia

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Preclinical Activity of New [1,2]Oxazolo[5,4‑e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma by Spanò, Virginia, Pennati, Marzia, Parrino, Barbara, Carbone, Anna, Montalbano, Alessandra, Cilibrasi, Vincenzo, Zuco, Valentina, Lopergolo, Alessia, Cominetti, Denis, Diana, Patrizia, Cirrincione, Girolamo, Barraja, Paola, Zaffaroni, Nadia

“…A series of 22 derivatives of the [1,2]­oxazolo­[5,4-e]­isoindole system were synthesized through an efficient and versatile procedure that involves the…”
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Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein by Spanò, Virginia, Barreca, Marilia, Cilibrasi, Vincenzo, Genovese, Michele, Renda, Mario, Montalbano, Alessandra, Galietta, Luis Juan Vicente, Barraja, Paola

“…Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del,…”
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GPCR Inhibition in Treating Lymphoma by Barreca, Marilia, Spanò, Virginia, Raimondi, Maria V, Bivacqua, Roberta, Giuffrida, Stefano, Montalbano, Alessandra, Cavalli, Andrea, Bertoni, Francesco, Barraja, Paola

“…G protein-coupled receptors (GPCRs) are important classes of cell surface receptors involved in multiple physiological functions. Aberrant expression,…”
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Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells by Barreca, Marilia, Ingarra, Angela Maria, Raimondi, Maria Valeria, Spanò, Virginia, De Franco, Michele, Menilli, Luca, Gandin, Valentina, Miolo, Giorgia, Barraja, Paola, Montalbano, Alessandra

“…Searching for new small molecules as photosensitizing agents, we have developed a class of twenty-five pyrimido[5,4-g]indolizine and…”
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Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors by Spanò, Virginia, Barreca, Marilia, Rocca, Roberta, Bortolozzi, Roberta, Bai, Ruoli, Carbone, Anna, Raimondi, Maria Valeria, Piccionello, Antonio Palumbo, Montalbano, Alessandra, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Barraja, Paola

“…A series of [1,3]thiazolo[4,5-e]isoindoles has been synthesized through a versatile and high yielding multistep sequence. Evaluation of the antiproliferative…”
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Novel 1H‑Pyrrolo[2,3‑b]pyridine Derivative Nortopsentin Analogues: Synthesis and Antitumor Activity in Peritoneal Mesothelioma Experimental Models by Carbone, Anna, Pennati, Marzia, Parrino, Barbara, Lopergolo, Alessia, Barraja, Paola, Montalbano, Alessandra, Spanò, Virginia, Sbarra, Stefania, Doldi, Valentina, De Cesare, Michelandrea, Cirrincione, Girolamo, Diana, Patrizia, Zaffaroni, Nadia

“…In this study, we describe the synthesis of new nortopsentin analogues, 1H-pyrrolo[2,3-b]pyridine derivatives and their biological effects in experimental…”
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Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line by Labbozzetta, Manuela, Barreca, Marilia, Spanò, Virginia, Raimondi, Maria Valeria, Poma, Paola, Notarbartolo, Monica, Barraja, Paola, Montalbano, Alessandra

“…A series of [1,2]oxazolo[5,4‐e]isoindole derivatives was evaluated against HL‐60 cell line and its multidrug resistance (MDR) variant, HL‐60R, resistant to…”
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Synthesis of 2H-Imidazo[2′,1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations by Cilibrasi, Vincenzo, Spanò, Virginia, Bortolozzi, Roberta, Barreca, Marilia, Raimondi, Maria Valeria, Rocca, Roberta, Maruca, Annalisa, Montalbano, Alessandra, Alcaro, Stefano, Ronca, Roberto, Viola, Giampietro, Barraja, Paola

“…Despite progressive advances in understanding the molecular biology of acute myeloid leukemia (AML), the conventional therapeutic approach has not changed…”
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Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors by Bivacqua, Roberta, Barreca, Marilia, Spanò, Virginia, Raimondi, Maria Valeria, Romeo, Isabella, Alcaro, Stefano, Andrei, Graciela, Barraja, Paola, Montalbano, Alessandra

“…Viruses have been recognized as the etiological agents responsible for many pathological conditions ranging from asymptomatic infections to serious diseases,…”
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The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma by Grillone, Katia, Riillo, Caterina, Rocca, Roberta, Ascrizzi, Serena, Spanò, Virginia, Scionti, Francesca, Polerà, Nicoletta, Maruca, Annalisa, Barreca, Marilia, Juli, Giada, Arbitrio, Mariamena, Di Martino, Maria Teresa, Caracciolo, Daniele, Tagliaferri, Pierosandro, Alcaro, Stefano, Montalbano, Alessandra, Barraja, Paola, Tassone, Pierfrancesco

“…Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was…”
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Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues by Parrino, Barbara, Attanzio, Alessandro, Spanò, Virginia, Cascioferro, Stella, Montalbano, Alessandra, Barraja, Paola, Tesoriere, Luisa, Diana, Patrizia, Cirrincione, Girolamo, Carbone, Anna

“…A new series of thiazole nortopsentin analogues was conveniently synthesized with fair overall yields. The antiproliferative activity of the new derivatives…”
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