Search Results - "Spaltenstein, Paul"

A glutamic acid-based traceless linker to address challenging chemical protein syntheses by Giesler, Riley J, Spaltenstein, Paul, Jacobsen, Michael T, Xu, Weiliang, Maqueda, Mercedes, Kay, Michael S

“…Native chemical ligation (NCL) enables the total chemical synthesis of proteins. However, poor peptide segment solubility remains a frequently encountered…”
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Traceless Click-Assisted Native Chemical Ligation Enabled by Protecting Dibenzocyclooctyne from Acid-Mediated Rearrangement with Copper(I) by Erickson, Patrick W, Fulcher, James M, Spaltenstein, Paul, Kay, Michael S

“…The scope of proteins accessible to total chemical synthesis via native chemical ligation (NCL) is often limited by slow ligation kinetics. Here we describe…”
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Selective Activation of Peptide-Thioester Precursors for Templated Native Chemical Ligations by Spaltenstein, Paul, Giesler, Riley J, Scherer, Samuel R, Erickson, Patrick W, Kay, Michael S

“…Chemical protein synthesis enables access to proteins that would otherwise be difficult or impossible to obtain with traditional means such as recombinant…”
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Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations by Spaltenstein, Paul, Giesler, Riley J., Scherer, Samuel R., Erickson, Patrick W., Kay, Michael S.

“…Abstract Chemical protein synthesis enables access to proteins that would otherwise be difficult or impossible to obtain with traditional means such as…”
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Sequential iodine-mediated diallylsilane rearrangement/asymmetric dihydroxylation: Synthesis and reactions of enantioenriched oxasilacycles by Myers, Christopher R., Spaltenstein, Paul, Baker, Lauren K., Schwans, Cody L., Clark, Timothy B., O'Neil, Gregory W.

“…[Display omitted] •A new sequence for enantioenriched oxasilacycle synthesis is reported.•Iodine-promoted diallylsilane rearrangement provides suitable…”
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Chemoselective Carbonyl Allylations with Alkoxyallylsiletanes by Spaltenstein, Paul, Cummins, Elizabeth J, Yokuda, Kelly-Marie, Kowalczyk, Tim, Clark, Timothy B, O’Neil, Gregory W

“…Alkoxyallylsiletanes are capable of highly chemo- and diastereoselective carbonyl allylsilylations. Reactive substrates include salicylaldehydes and glyoxylic…”
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