Search Results - "Spalinger, M"

PTPN2 controls differentiation of CD4+ T cells and limits intestinal inflammation and intestinal dysbiosis by Spalinger, M R, Kasper, S, Chassard, C, Raselli, T, Frey-Wagner, I, Gottier, C, Lang, S, Atrott, K, Vavricka, S R, Mair, F, Becher, B, Lacroix, C, Fried, M, Rogler, G, Scharl, M

“…Loss-of-function variants within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) are associated with increased risk for…”
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The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis by Raselli, T, Wyss, A, Gonzalez Alvarado, M N, Weder, B, Mamie, C, Spalinger, M R, Van Haaften, W T, Dijkstra, G, Sailer, A W, Imenez Silva, P H, Wagner, C A, Tosevski, V, Leibl, Sebastian, Scharl, M, Rogler, G, Hausmann, M, Misselwitz, B

“…Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD], frequently requiring surgery. Anti-inflammatory strategies can only…”
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The influence of soil remediation on lead in house dust by von Lindern, Ian H., Spalinger, Susan M., Bero, Bridget N., Petrosyan, Varduhi, von Braun, Margrit C.

“…Lead in house dust has long been recognized as a principal source of excess lead absorption among children at the Bunker Hill Superfund Site (BHSS) in northern…”
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Evaluation of the integrated exposure uptake biokinetic (IEUBK) model for lead in children by Brown, James S., Spalinger, Susan M., Weppner, Sarah G., Hicks, Kynan J. Witters, Thorhaug, Mara, Thayer, William C., Follansbee, Mark H., Diamond, Gary L.

“…Background The Integrated Exposure Uptake Biokinetic Model for Lead in Children (IEUBK model) was developed by the U.S. Environmental Protection Agency to…”
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Admixture of a Multivitamin Preparation to Parenteral Nutrition: The Major Contributor to In Vitro Generation of Peroxides by Lavoie, Jean-Claude, Belanger, Sylvie, Spalinger, Monica, Chessex, Philippe

“…Peroxides have been reported to contaminate lipid emulsions and amino acid solutions used in total parenteral nutrition (TPN). This is particularly disturbing…”
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Seasonal variations of lead concentration and loading rates in residential house dust in northern Idaho by Petrosyan, Varduhi, von Braun, Margrit C., Spalinger, Susan M., von Lindern, Ian H.

“…Although lead hazards to humans have been known since ancient times and many regulatory actions and lead risk reductions have been achieved over the past…”
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Environmental Lead Contamination in the Rudnaya Pristan – Dalnegorsk Mining and Smelter District, Russian Far East by von Braun, Margrit C., von Lindern, Ian H., Khristoforova, Nadezhda K., Kachur, Anatoli H., Yelpatyevsky, Pavel V., Elpatyevskaya, Vera P., Spalinger, Susan M.

“…A preliminary survey of a remote mining and smelting region of the Russian Far East (RFE) indicates significant soil lead contamination and a high probability…”
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P061 The macrophage-specific role of PTPN23 in Acute and Chronic Colitis by Linzmeier, L, Matus, V, Determann, M, Wilmink, M, Schwarzfischer, M, Sanchez Alvarez, R, Pöhlmann, D, Scharl, M, Spalinger, M

“…Abstract Background Single nucleotide polymorphisms within the gene locus encoding PTPN2, are associated with Crohn’s disease and ulcerative colitis. We have…”
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DOP51 Loss of PTPN23 in the intestinal epithelium results in epithelial hyperproliferation and lethal diarrhea in a microbiota dependent manner by Spalinger, M, Sanchez Alvarez, R, Gottier, C, Montalban-Arques, A, Schwarzfischer, M, Niechcial, A, Scharl, M

“…Abstract Background Protein tyrosine phosphtase non-receptor type 23 (PTPN23) plays a critical role in regulating epidermal growth factor (EGF) receptor…”
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P025 Identification and validation of predictors for tofacitinib through supervised and unbiased approaches in Inflammatory Bowel Disease by Liu, B, Spalinger, M, Perez, L G, Machicote, A, Gagliani, N, Scharl, M, Huber, S

“…Abstract Background Inflammatory Bowel Disease (IBD) is characterized by an overwhelming gut inflammation, where CD4+ effector T cells are main mediators of…”
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P006 Loss of protein tyrosine phosphatase non-receptor type 23 (PTPN23) in intestinal epithelial cells induces inflammation and epithelial hyperproliferation by Montalban-Arques, A, Gottier, C, Olivares-Rivas, I, Scharl, M, Spalinger, M

“…Abstract Background Colorectal carcinoma (CRC) is still a mayor complication in patients with inflammatory bowel disease (IBD) with colonic involvement…”
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P033 Combination of vedolizumab with tacrolimus is more efficient in reducing intestinal inflammation than vedolizumab alone in the DSS-induced acute colitis mouse model by Manzini, R, Atrott, K, Schwarzfischer, M, Laimbacher, A, Lang, S, Rogler, G, Scharl, M, Spalinger, M R

“…Abstract Background The humanised monoclonal antibody vedolizumab is used in the treatment of ulcerative colitis (UC) and Crohn’s disease (CD). Vedolizumab…”
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P068 Loss of PTPN22 abrogates the beneficial effect of faecal microbiota transfer by Spalinger, M, Schwarzfischer, M, Gottier, C, Hering, L, Lang, S, Rogler, G, Scharl, M

“…Abstract Background In inflammatory bowel disease (IBD), shifts in microbiota composition and reduced microbial diversity have been described. There are…”
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OP030 Loss of PTPN2 in dendritic cells promotes T-cell activation and expression of co-stimulatory molecules by Hering, L, Gottier, C, Lang, S, Becher, B, Rogler, G, Scharl, M, Spalinger, M

“…Abstract Background Variants within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) are associated with the development of…”
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DOP079 Heat-shock protein GP96 is essential for self-renewal of the intestinal epithelial barrier by Schwarzfischer, M, Morsy, Y, Atrott, K, Stanzel, C, Lang, S, Rogler, G, Scharl, M, Spalinger, M

“…Abstract Background The intestinal epithelium constitutes an important barrier that separates the body from the external environment to prevent access of…”
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DOP02 Supplementation with butyrate producing bacteria reduces tumour load in a mouse model of colitis-associated cancer by Montalban Arques, A, Olivares Rivas, I, Atrott, K, Gottier, C, Lang, S, Leventhal, G, DeWouters, T, Scharl, M, Spalinger, M

“…Abstract Background Colorectal carcinoma is still a severe complication in patients with long-standing and severe ulcerative colitis. Current guidelines…”
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P052 Heat shock protein GP96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity by Häfliger, J, Schwarzfischer, M, Van de Sande, M, Manzini, R, Stanzel, C, Atrott, K, Lang, S, Scharl, M, Spalinger, M

“…Abstract Background The intestinal epithelium is characterised by a remarkable self-renewal capacity and a high turnover of intestinal epithelial cells (IEC),…”
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DOP14 TiO2 nanoparticles abrogate the protective effect of the autoimmunity-associated PTPN22R619W variant during acute DSS colitis by Schwarzfischer, M, Hering, L, Katkeviciute, E, Niechcial, A, Atrott, K, Bäbler, K, Busenhart, P, Rogler, G, Scharl, M, Spalinger, M

“…Abstract Background Titanium dioxide (TiO2), commonly used in comestible goods and personal care products, is omnipresent in everyone’s daily life. TiO2…”
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DOP19 Spermidine treatment ameliorates experimental colitis in vivo by Niechcial, A, Katkeviciute, E, Hering, L, Wawrzyniak, M, Schwarzfischer, M, Bäbler, K, Attrot, K, Scharl, M, Spalinger, M R

“…Abstract Background Genetic variations within the gene encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) are associated with an increased risk…”
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Glutathione synthetic activity in the lungs in newborn guinea pigs by Lavoie, J C, Spalinger, M, Chessex, P

“…Depletion of glutathione, a key antioxidant, accelerates lung injury. Glutathione concentrations are reduced significantly in premature infants with…”
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