Search Results - "Spahn, M."

Structural basis of early translocation events on the ribosome by Rundlet, Emily J., Holm, Mikael, Schacherl, Magdalena, Natchiar, S. Kundhavai, Altman, Roger B., Spahn, Christian M. T., Myasnikov, Alexander G., Blanchard, Scott C.

“…Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2–20 per…”
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The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre by Fritsch, Johannes, Scheerer, Patrick, Frielingsdorf, Stefan, Kroschinsky, Sebastian, Friedrich, Bärbel, Lenz, Oliver, Spahn, Christian M. T.

“…Oxygen-tolerant hydrogenases Hydrogenases are metalloprotein enzymes that catalyse the reversible oxidation of dihydrogen to protons and electrons, a critical…”
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MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer by Kalogirou, C., Linxweiler, J., Schmucker, P., Snaebjornsson, M. T., Schmitz, W., Wach, S., Krebs, M., Hartmann, E., Puhr, M., Müller, A., Spahn, M., Seitz, A. K., Frank, T., Marouf, H., Büchel, G., Eckstein, M., Kübler, H., Eilers, M., Saar, M., Junker, K., Röhrig, F., Kneitz, B., Rosenfeldt, M. T., Schulze, A.

“…Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol…”
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Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites by Yu, Yanan, Fucini, Paola, Sanbonmatsu, Karissa Y, Wilson, Daniel N, Starosta, Agata L, Onuchic, José N, Mikolajka, Aleksandra, Brünner, Matthias, Hildebrand, Peter W, Ratje, Andreas H, Connell, Sean R, Penczek, Pawel A, Spahn, Christian M. T, Loerke, Justus, Dönhöfer, Alexandra, Whitford, Paul C, Mielke, Thorsten, Hartmann, Roland K

“…The elongation cycle of protein synthesis involves the delivery of aminoacyl-transfer RNAs to the aminoacyl-tRNA-binding site (A site) of the ribosome,…”
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Cryo-EM structure of the Shigella type III needle complex by Lunelli, Michele, Kamprad, Antje, Bürger, Jörg, Mielke, Thorsten, Spahn, Christian M T, Kolbe, Michael

“…The Type III Secretion Systems (T3SS) needle complex is a conserved syringe-shaped protein translocation nanomachine with a mass of about 3.5 MDa essential for…”
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Influence of maternal diet on flavor transfer to amniotic fluid and breast milk and children's responses: a systematic review by Spahn, Joanne M, Callahan, Emily H, Spill, Maureen K, Wong, Yat Ping, Benjamin-Neelon, Sara E, Birch, Leann, Black, Maureen M, Cook, John T, Faith, Myles S, Mennella, Julie A, Casavale, Kellie O

“…Maternal diet during pregnancy and lactation may provide the earliest opportunity to positively influence child food acceptance. Systematic reviews were…”
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Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments by Melo, Arthur A., Sprink, Thiemo, Noel, Jeffrey K., Vázquez-Sarandeses, Elena, van Hoorn, Chris, Mohd, Saif, Loerke, Justus, Spahn, Christian M. T., Daumke, Oliver

“…Eps15-homology domain containing proteins (EHDs) are eukaryotic, dynamin-related ATPases involved in cellular membrane trafficking. They oligomerize on…”
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A critical period of translational control during brain development at codon resolution by Harnett, Dermot, Ambrozkiewicz, Mateusz C., Zinnall, Ulrike, Rusanova, Alexandra, Borisova, Ekaterina, Drescher, Amelie N., Couce-Iglesias, Marta, Villamil, Gabriel, Dannenberg, Rike, Imami, Koshi, Münster-Wandowski, Agnieszka, Fauler, Beatrix, Mielke, Thorsten, Selbach, Matthias, Landthaler, Markus, Spahn, Christian M. T., Tarabykin, Victor, Ohler, Uwe, Kraushar, Matthew L.

“…Translation modulates the timing and amplification of gene expression after transcription. Brain development requires uniquely complex gene expression…”
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Translatomics: The Global View of Translation by Zhao, Jing, Qin, Bo, Nikolay, Rainer, Spahn, Christian M T, Zhang, Gong

“…In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as translation. The amplitude of translational regulation exceeds the…”
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Dietary patterns before and during pregnancy and birth outcomes: a systematic review by Raghavan, Ramkripa, Dreibelbis, Carol, Kingshipp, Brittany L, Wong, Yat Ping, Abrams, Barbara, Gernand, Alison D, Rasmussen, Kathleen M, Siega-Riz, Anna Maria, Stang, Jamie, Casavale, Kellie O, Spahn, Joanne M, Stoody, Eve E

“…Maternal diet before and during pregnancy could influence fetal growth and birth outcomes. Two systematic reviews aimed to assess the relationships between…”
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Cryo-EM captures early ribosome assembly in action by Qin, Bo, Lauer, Simon M., Balke, Annika, Vieira-Vieira, Carlos H., Bürger, Jörg, Mielke, Thorsten, Selbach, Matthias, Scheerer, Patrick, Spahn, Christian M. T., Nikolay, Rainer

“…Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification of…”
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Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88 by Lauer, Simon M., Reepmeyer, Maren, Berendes, Ole, Klepacki, Dorota, Gasse, Jakob, Gabrielli, Sara, Grubmüller, Helmut, Bock, Lars V., Krizsan, Andor, Nikolay, Rainer, Spahn, Christian M. T., Hoffmann, Ralf

“…Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial protein biosynthesis by binding to the polypeptide exit tunnel (PET) near the peptidyl…”
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Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM by Flügel, Timo, Schacherl, Magdalena, Unbehaun, Anett, Schroeer, Birgit, Dabrowski, Marylena, Bürger, Jörg, Mielke, Thorsten, Sprink, Thiemo, Diebolder, Christoph A., Guillén Schlippe, Yollete V., Spahn, Christian M. T.

“…Structural studies of translating ribosomes traditionally rely on in vitro assembly and stalling of ribosomes in defined states. To comprehensively visualize…”
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Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates by Grunwald, Stephan, Hopf, Linus V. M., Bock-Bierbaum, Tobias, Lally, Ciara C. M., Spahn, Christian M. T., Daumke, Oliver

“…The heterotrimeric NatC complex, comprising the catalytic Naa30 and the two auxiliary subunits Naa35 and Naa38, co-translationally acetylates the N-termini of…”
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Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide by Heyder, Nicolas A., Kleinau, Gunnar, Speck, David, Schmidt, Andrea, Paisdzior, Sarah, Szczepek, Michal, Bauer, Brian, Koch, Anja, Gallandi, Monique, Kwiatkowski, Dennis, Bürger, Jörg, Mielke, Thorsten, Beck-Sickinger, Annette G., Hildebrand, Peter W., Spahn, Christian M. T., Hilger, Daniel, Schacherl, Magdalena, Biebermann, Heike, Hilal, Tarek, Kühnen, Peter, Kobilka, Brian K., Scheerer, Patrick

“…The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a class A G-protein-coupled receptor and a prime…”
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Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses by Banchenko, Sofia, Krupp, Ferdinand, Gotthold, Christine, Bürger, Jörg, Graziadei, Andrea, O'Reilly, Francis J, Sinn, Ludwig, Ruda, Olga, Rappsilber, Juri, Spahn, Christian M T, Mielke, Thorsten, Taylor, Ian A, Schwefel, David

“…Viruses have evolved means to manipulate the host's ubiquitin-proteasome system, in order to down-regulate antiviral host factors. The Vpx/Vpr family of…”
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Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation by Ramrath, David J. F., Lancaster, Laura, Sprink, Thiemo, Mielke, Thorsten, Loerke, Justus, Noller, Harry F., Spahn, Christian M. T.

“…During protein synthesis, coupled translocation of messenger RNAs (mRNA) and transfer RNAs (tRNA) through the ribosome takes place following formation of each…”
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Protein translation rate determines neocortical neuron fate by Borisova, Ekaterina, Newman, Andrew G., Couce Iglesias, Marta, Dannenberg, Rike, Schaub, Theres, Qin, Bo, Rusanova, Alexandra, Brockmann, Marisa, Koch, Janina, Daniels, Marieatou, Turko, Paul, Jahn, Olaf, Kaplan, David R., Rosário, Marta, Iwawaki, Takao, Spahn, Christian M. T., Rosenmund, Christian, Meierhofer, David, Kraushar, Matthew L., Tarabykin, Victor, Ambrozkiewicz, Mateusz C.

“…The mammalian neocortex comprises an enormous diversity regarding cell types, morphology, and connectivity. In this work, we discover a post-transcriptional…”
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Dietary Energy Density and Body Weight in Adults and Children: A Systematic Review by Pérez-Escamilla, Rafael, PhD, Obbagy, Julie E., PhD, RD, Altman, Jean M., MS, Essery, Eve V., PhD, McGrane, Mary M., PhD, Wong, Yat Ping, MLS, MPH, Spahn, Joanne M., MS, RD, FADA, Williams, Christine L., MD, MPH

“…Abstract Energy density is a relatively new concept that has been identified as an important factor in body weight control in adults and in children and…”
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A new system for naming ribosomal proteins by Ban, Nenad, Beckmann, Roland, Cate, Jamie HD, Dinman, Jonathan D, Dragon, François, Ellis, Steven R, Lafontaine, Denis LJ, Lindahl, Lasse, Liljas, Anders, Lipton, Jeffrey M, McAlear, Michael A, Moore, Peter B, Noller, Harry F, Ortega, Joaquin, Panse, Vikram Govind, Ramakrishnan, V, Spahn, Christian MT, Steitz, Thomas A, Tchorzewski, Marek, Tollervey, David, Warren, Alan J, Williamson, James R, Wilson, Daniel, Yonath, Ada, Yusupov, Marat

“…A system for naming ribosomal proteins is described that the authors intend to use in the future. They urge others to adopt it. The objective is to eliminate…”
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