Search Results - "Spahn, Joseph"

Combination inhaled glucocorticoid/long-acting beta-agonist safety: The long and winding road by Spahn, Joseph D

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Author response by Spahn, Joseph D.

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Current Application of Exhaled Nitric Oxide in Clinical Practice by Spahn, Joseph D, Malka, Jonathan, Szefler, Stanley J

“…Values of less than 25 ppb in adults (<20 ppb children) are considered low; intermediate values are 25 to 50 ppb in adults (20-35 ppb children), and high…”
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Severe Asthma with Onset in Adulthood is a Distinct Phenotype that is Most Likely to Respond to Mepolizumab by McCormack, Katherine, Comberiati, Pasquale, Spahn, Joseph D.

“…Children were more likely to be male, have been hospitalized, less likely to have required chronic oral steroids, had fewer eosinophils, nasal polyps, and…”
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Lung mechanical properties distinguish children with asthma with normal and diminished lung function by Comberiati, Pasquale, Spahn, Joseph D., Paull, Keith, Faino, Anna, Cherniack, Reuben, Covar, Ronina A.

“…Background Children with asthma, even those with severe persistent disease, can have forced expiratory volume in 1 second (FEV1) values ≥100% of predicted,…”
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Fractional exhaled nitric oxide response to oral corticosteroids in children with mild-to-moderate asthma: Influence of race by Comberiati, Pasquale, Peroni, Diego, Malka-Rais, Jonathan, Morganti, Riccardo, Spahn, Joseph D

“…BACKGROUNDFractional exhaled nitric oxide (FeNO) is a noninvasive biomarker of type 2 asthma that can predict response to inhaled corticosteroid therapy…”
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Proportion of Severe Asthma Patients Eligible for Mepolizumab Therapy by Age and Age of Onset of Asthma by Comberiati, Pasquale, McCormack, Katherine, Malka-Rais, Jonathan, Spahn, Joseph D.

“…Mepolizumab is an anti–IL-5 antibody approved for the treatment of severe eosinophilic asthma. However, the prevalence of patients with severe asthma eligible…”
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Step-up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids by Lemanske, Robert F, Mauger, David T, Sorkness, Christine A, Jackson, Daniel J, Boehmer, Susan J, Martinez, Fernando D, Strunk, Robert C, Szefler, Stanley J, Zeiger, Robert S, Bacharier, Leonard B, Covar, Ronina A, Guilbert, Theresa W, Larsen, Gary, Morgan, Wayne J, Moss, Mark H, Spahn, Joseph D, Taussig, Lynn M

“…Many children have uncontrolled asthma symptoms when treated with low-dose inhaled corticosteroids (ICS). In this three-way crossover trial, the investigators…”
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Wheeze is an unreliable endpoint for bronchial methacholine challenges in preschool children by Stewart, Lora, Miyazawa, Naomi, Covar, Ronina, Mjaanes, Christopher, Shimamoto, Reed, Gleason, Melanie, Peroni, Diego, Spahn, Joseph D, Comberiati, Pasquale

“…Onset of wheeze is the endpoint often used in the determination of a positive bronchial challenge test (BCT) in young children who cannot perform spirometry…”
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Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR) by Pavord, Ian D., Hoyte, Flavia C.L., Lindsley, Andrew W., Ambrose, Christopher S., Spahn, Joseph D., Roseti, Stephanie L., Cook, Bill, Griffiths, Janet M., Hellqvist, Åsa, Martin, Nicole, Llanos, Jean-Pierre, Martin, Neil, Colice, Gene, Corren, Jonathan

“…BACKGROUNDAsthma exacerbation frequencies vary throughout the year owing to seasonal triggers. Tezepelumab is a human monoclonal antibody that targets thymic…”
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Predictors of remitting, periodic, and persistent childhood asthma by Covar, Ronina A., MD, Strunk, Robert, MD, Zeiger, Robert S., MD, PhD, Wilson, Laura A., ScM, Liu, Andrew H., MD, Weiss, Scott, MD, MSc, Tonascia, James, PhD, Spahn, Joseph D., MD, Szefler, Stanley J., MD

“…Background The course of mild to moderate persistent asthma in children is not clearly established. Objective To determine the rate and predictors for…”
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Effect of Tezepelumab on Sino-Nasal Outcome Test (SNOT)-22 Domain and Symptom-Specific Scores in Patients with Severe, Uncontrolled Asthma and a History of Chronic Rhinosinusitis with Nasal Polyps by Jacobs, Joshua S., Han, Joseph K., Lee, Jason K., Laidlaw, Tanya M., Martin, Nicole L., Caveney, Scott, Ambrose, Christopher S., Martin, Neil, Spahn, Joseph D., Hoyte, Flavia C. L.

“…Tezepelumab blocks the activity of thymic stromal lymphopoietin, an epithelial cytokine implicated in the pathogenesis of asthma and chronic rhinosinusitis…”
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Inflammometry in pediatric asthma: a review of fractional exhaled nitric oxide in clinical practice by Mahr, Todd A, Malka, Jonathan, Spahn, Joseph D

“…The burden of pediatric asthma remains high with one-third of patients being under- or overtreated because of the unique challenges in the assessment and…”
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Characterization of within-subject responses to fluticasone and montelukast in childhood asthma by Szefler, Stanley J., Phillips, Brenda R., Martinez, Fernando D., Chinchilli, Vernon M., Lemanske, Robert F., Strunk, Robert C., Zeiger, Robert S., Larsen, Gary, Spahn, Joseph D., Bacharier, Leonard B., Bloomberg, Gordon R., Guilbert, Theresa W., Heldt, Gregory, Morgan, Wayne J., Moss, Mark H., Sorkness, Christine A., Taussig, Lynn M.

“…Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients. We sought to determine whether…”
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Clinical assessment of asthma progression in children and adults by Spahn, Joseph D., MD, Covar, Ronina, MD

“…Asthma is a heterogeneous disorder with a variable course, characterized by episodes of cough, wheezing and shortness of breath, reversible airflow limitation,…”
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Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: The Pediatric Asthma Controller Trial by Sorkness, Christine A., PharmD, Lemanske, Robert F., MD, Mauger, David T., PhD, Boehmer, Susan J., MA, Chinchilli, Vernon M., PhD, Martinez, Fernando D., MD, Strunk, Robert C., MD, Szefler, Stanley J., MD, Zeiger, Robert S., MD, PhD, Bacharier, Leonard B., MD, Bloomberg, Gordon R., MD, Covar, Ronina A., MD, Guilbert, Theresa W., MD, Heldt, Gregory, MD, Larsen, Gary, MD, Mellon, Michael H., MD, Morgan, Wayne J., MD, Moss, Mark H., MD, Spahn, Joseph D., MD, Taussig, Lynn M., MD

“…Background More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children. Objective The…”
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Eczema and race as combined determinants for differential response to step-up asthma therapy by Malka, Jonathan, MD, Mauger, David T., PhD, Covar, Ronina, MD, Rabinovitch, Nathan, MD, MPH, Lemanske, Robert F., MD, Spahn, Joseph D., MD, Strunk, Robert C., MD, Zeiger, Robert S., MD, PhD, Morgan, Wayne J., MD, Szefler, Stanley J., MD

“…[...]LABA step-up therapy is the preferred step-up therapy in asthmatic children without eczema…”
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Effect of Biologic Therapies on Airway Hyperresponsiveness and Allergic Response: A Systematic Literature Review by Spahn, Joseph D, Brightling, Christopher E, O'Byrne, Paul M, Simpson, Lisa J, Molfino, Nestor A, Ambrose, Christopher S, Martin, Neil, Hallstrand, Teal S

“…Airway hyperresponsiveness (AHR) is a key feature of asthma. Biologic therapies used to treat asthma target specific components of the inflammatory pathway,…”
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Ethnic Differences in Exhaled Nitric Oxide (FeNO) Before, During, and After an Asthma Exacerbation in Children with Asthma by McCormack, Katherine, MD, Malka, Jonathan, MD, FAAAAI, Gleason, Melanie C., MS, PA-C, Spahn, Joseph D., MD

“…Methods 131 children (67 Caucasians, 37 Hispanics, 27 AA's) with moderate asthma had exhaled nitric oxide (FeNO) and spirometry measured before, during and…”
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The chitinase-like protein YKL-40 is not a useful biomarker for severe persistent asthma in children by Santos, Carah B., MD, Davidson, Joshua, MD, Covar, Ronina A., MD, Spahn, Joseph D., MD

“…Abstract Background The chitinase-like protein YKL-40 is thought to play a role in inflammation and tissue remodeling. In adults with severe asthma, YKL-40 is…”
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