Search Results - "Spagnolo, Laura"

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling by van Beek, Lotte, McClay, Éilís, Patel, Saleha, Schimpl, Marianne, Spagnolo, Laura, Maia de Oliveira, Taiana

“…Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes, catalysing the covalent modification of proteins, DNA, and themselves. They…”
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Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity by Zhang, Jing, Rouillon, Christophe, Kerou, Melina, Reeks, Judith, Brugger, Kim, Graham, Shirley, Reimann, Julia, Cannone, Giuseppe, Liu, Huanting, Albers, Sonja-Verena, Naismith, James H., Spagnolo, Laura, White, Malcolm F.

“…The prokaryotic clusters of regularly interspaced palindromic repeats (CRISPR) system utilizes genomically encoded CRISPR RNA (crRNA), derived from invading…”
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Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA by Rennie, Martin L, Lemonidis, Kimon, Arkinson, Connor, Chaugule, Viduth K, Clarke, Mairi, Streetley, James, Spagnolo, Laura, Walden, Helen

“…The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms…”
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Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair by Spagnolo, Laura, Rivera-Calzada, Angel, Pearl, Laurence H., Llorca, Oscar

“…DNA-PKcs is a large (∼470 kDa) kinase that plays an essential role in the repair of DNA double-strand breaks (DSBs) by nonhomologous end joining (NHEJ)…”
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Photobacterium profundum under pressure: a MS-based label-free quantitative proteomics study by Le Bihan, Thierry, Rayner, Joe, Roy, Marcia M, Spagnolo, Laura

“…Photobacterium profundum SS9 is a Gram-negative bacterium, originally collected from the Sulu Sea. Its genome consists of two chromosomes and a 80 kb plasmid…”
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Structure of the Saccharolobus solfataricus type III-D CRISPR effector by Cannone, Giuseppe, Kompaniiets, Dmytro, Graham, Shirley, White, Malcolm F., Spagnolo, Laura

“…CRISPR-Cas is a prokaryotic adaptive immune system, classified into six different types, each characterised by a signature protein. Type III systems,…”
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Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs by Rivera-Calzada, Angel, Spagnolo, Laura, Pearl, Laurence H, Llorca, Oscar

“…Recognition of DNA double‐strand breaks during non‐homologous end joining is carried out by the Ku70–Ku80 protein, a 150 kDa heterodimer that recruits the DNA…”
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The architecture of an Okazaki fragment-processing holoenzyme from the archaeon Sulfolobus solfataricus by Cannone, Giuseppe, Xu, Yuli, Beattie, Thomas R, Bell, Stephen D, Spagnolo, Laura

“…DNA replication on the lagging strand occurs via the synthesis and maturation of Okazaki fragments. In archaea and eukaryotes, the enzymatic activities…”
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Cyclic nucleotide-induced helical structure activates a TIR immune effector by Hogrel, Gaëlle, Guild, Abbie, Graham, Shirley, Rickman, Hannah, Grüschow, Sabine, Bertrand, Quentin, Spagnolo, Laura, White, Malcolm F.

“…Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life. Viral detection activates a nucleotide cyclase to generate a…”
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Unique Features of the sodC-encoded Superoxide Dismutase from Mycobacterium tuberculosis, a Fully Functional Copper-containing Enzyme Lacking Zinc in the Active Site by Spagnolo, Laura, Törö, Imre, D'Orazio, Melania, O'Neill, Peter, Pedersen, Jens Z., Carugo, Oliviero, Rotilio, Giuseppe, Battistoni, Andrea, Djinović-Carugo, Kristina

“…The sodC-encoded Mycobacterium tuberculosis superoxide dismutase (SOD) shows high sequence homology to other members of the copper/zinc-containing SOD family…”
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Author Correction: Cyclic nucleotide-induced helical structure activates a TIR immune effector by Hogrel, Gaëlle, Guild, Abbie, Graham, Shirley, Rickman, Hannah, Grüschow, Sabine, Bertrand, Quentin, Spagnolo, Laura, White, Malcolm F.

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Structure of the CRISPR Interference Complex CSM Reveals Key Similarities with Cascade by Rouillon, Christophe, Zhou, Min, Zhang, Jing, Politis, Argyris, Beilsten-Edmands, Victoria, Cannone, Giuseppe, Graham, Shirley, Robinson, Carol V., Spagnolo, Laura, White, Malcolm F.

“…The Clustered Regularly Interspaced Palindromic Repeats (CRISPR) system is an adaptive immune system in prokaryotes. Interference complexes encoded by…”
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Visualization of a DNA-PK/PARP1 complex by Spagnolo, Laura, Barbeau, Jody, Curtin, Nicola J, Morris, Edward P, Pearl, Laurence H

“…The DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribose) polymerase-1 (PARP1) are critical enzymes that reduce genomic damage caused by DNA lesions. They…”
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Structure of an octameric form of the minichromosome maintenance protein from the archaeon Pyrococcus abyssi by Cannone, Giuseppe, Visentin, Silvia, Palud, Adeline, Henneke, Ghislaine, Spagnolo, Laura

“…Cell division is a complex process that requires precise duplication of genetic material. Duplication is concerted by replisomes. The Minichromosome…”
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A multipronged approach to understanding the form and function of hStaufen protein by Visentin, Silvia, Cannone, Giuseppe, Doutch, James, Harris, Gemma, Gleghorn, Michael L, Clifton, Luke, Smith, Brian O, Spagnolo, Laura

“…Staufen is a dsRNA-binding protein involved in many aspects of RNA regulation, such as mRNA transport, Staufen-mediated mRNA decay and the regulation of mRNA…”
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Electron microscopy studies of Type III CRISPR machines in Sulfolobus solfataricus by Cannone, Giuseppe, Webber-Birungi, Mariam, Spagnolo, Laura

“…The CRISPR (clustered regularly interspaced short palindromic repeats) system is an adaptive immune system that targets viruses and other mobile genetic…”
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Inequidad salarial en Cuba durante el periodo especial by Galbraith, James K, Spagnolo, Laura, Munevar, Daniel

“…Este trabajo analiza la evolución de la inequidad salarial en Cuba desde principios de la década de 1990 hasta 2004, durante y luego de lo que fue conocido…”
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Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies by Morris, Edward P., Rivera-Calzada, Angel, da Fonseca, Paula C. A., Llorca, Oscar, Pearl, Laurence H., Spagnolo, Laura

“…The multi-subunit DNA-dependent protein kinase (DNA-PK), a crucial player in DNA repair by non-homologous end-joining in higher eukaryotes, consists of a…”
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The decline of pay inequality in Argentina and Brazil following the crises and retreat from the neo-liberal model by James K. Galbraith, Laura Spagnolo, Sergio Pinto

“…We analyze the distribution of payment in Argentina and Brazil to develop a new insight into trends of economic inequality in the two countries. The use of the…”
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Three-Dimensional Structure and Regulation of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) by Rivera-Calzada, Angel, Maman, Joseph P., Spagnolo, Laura, Pearl, Laurence H., Llorca, Oscar

“…DNA-PKcs is a large PI3-kinase-related protein kinase (PIKK) that plays a central role in DNA double-strand break (DSB) repair via nonhomologous end joining…”
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