Search Results - "Spadea, Alice"

Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines by Rios De La Rosa, Julio M., Spadea, Alice, Donno, Roberto, Lallana, Enrique, Lu, Yu, Puri, Sanyogitta, Caswell, Patrick, Lawrence, M. Jayne, Ashford, Marianne, Tirelli, Nicola

“…This study is about fine tuning the targeting capacity of peptide-decorated nanoparticles to discriminate between cells that express different integrin…”
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Targeting Hypoxia-Inducible Factor-1α in Pancreatic Cancer: siRNA Delivery Using Hyaluronic Acid-Displaying Nanoparticles by Spadea, Alice, Tirella, Annalisa, Rios de la Rosa, Julio Manuel, Lallana, Enrique, Mehibel, Manal, Telfer, Brian, Tirelli, Nicola, Lawrence, Margaret Jayne, Williams, Kaye J, Stratford, Ian J, Ashford, Marianne

“…Conventional anticancer therapies often lack specificity, targeting both cancerous and normal cells, which reduces efficacy and leads to undesired off-target…”
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Analysis of Fixed and Live Single Cells Using Optical Photothermal Infrared with Concomitant Raman Spectroscopy by Spadea, Alice, Denbigh, Joanna, Lawrence, M. Jayne, Kansiz, Mustafa, Gardner, Peter

“…This paper reports the first use of a novel completely optically based photothermal method (O-PTIR) for obtaining infrared spectra of both fixed and living…”
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Nucleic Acid-Loaded Lipid Nanoparticle Interactions with Model Endosomal Membranes by Spadea, Alice, Jackman, Mark, Cui, Lili, Pereira, Sara, Lawrence, M. Jayne, Campbell, Richard A., Ashford, Marianne

“…Lipid nanoparticles (LNPs) are important delivery systems for RNA-based therapeutics, yet the mechanism of their interaction with endosomal membranes remains…”
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Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44 by Spadea, Alice, Rios de la Rosa, Julio Manuel, Tirella, Annalisa, Ashford, Marianne B, Williams, Kaye J, Stratford, Ian J, Tirelli, Nicola, Mehibel, Manal

“…The development of delivery systems capable of tumor targeting represents a promising strategy to overcome issues related to nonspecific effects of…”
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Binding and Internalization in Receptor‐Targeted Carriers: The Complex Role of CD44 in the Uptake of Hyaluronic Acid‐Based Nanoparticles (siRNA Delivery) by Rios de la Rosa, Julio M., Pingrajai, Ponpawee, Pelliccia, Maria, Spadea, Alice, Lallana, Enrique, Gennari, Arianna, Stratford, Ian J., Rocchia, Walter, Tirella, Annalisa, Tirelli, Nicola

“…CD44 is an endocytic hyaluronic acid (HA) receptor, and is overexpressed in many carcinomas. This has encouraged the use of HA to design CD44‐targeting…”
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Hyaluronic Acid Based Nanoparticles for Specific Tumour Targeting by Spadea, Alice

“…Two of the main limitations of conventional cancer drugs are their lack of ability to discriminate between cancer and normal cells, producing the well-known…”
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